Ion V. Deaciuc, Gregory J. Bagby, Charles H. Lang, John J. Spitzer – 1 February 1993 – Previous studies indicate that sinusoidal endothelial cells bind and internalize hyaluronic acid at much greater rates than do other liver cells. Thus hepatic hyaluronic acid removal rate may be indicative of sinusoidal endothelial cell function. In these studies the uptake of hyaluronic acid (molecular weight 1.3 × 106) was measured in isolated perfused rat liver under a variety of conditions. Uptake was dependent on hyaluronic acid concentration.

Delai Zhao, Arthur Zimmermann, Anthony M. Wheatley – 1 February 1993 – Two models of orthotopic liver transplantation in the rat currently used are with and without reconstruction of the hepatic artery. The aim of this study was to assess the importance of the arterial blood supply to liver structure after orthotopic liver transplantation with advanced morphometric methods. Orthotopic liver transplantation was performed in male Lewis rats, of which 11 underwent reconstruction of the hepatic artery and 11 did not.

Piotr Zimniak, Yogesh C. Awasthi – 1 February 1993

John A. Hermos – 1 February 1993

Nancy Rolando, Alexander Gimson, Jim Wade, John Philpott‐Howard, Mark Casewell, Roger Williams – 1 February 1993 – To compare the efficacy of a selective parenteral and enteral antimicrobial regimen in patients with fulminant liver failure, we classified 104 patients on reaching grade II encephalopathy as infected or noninfected. Patients who were infected were randomly assigned to receive IV cefuroxime (group 1) or selective parenteral and enteral antimicrobial regimen (group 2).

Shuichi Terasaki, Yasuni Nakanuma, Masakazu Yamazaki, Masashi Unoura – 1 February 1993 – Eosinophils and their secretory proteins are important in necroinflammatory processes. In this study we surveyed eosinophilic infiltration of the liver in 176 liver biopsy specimens from patients with primary biliary cirrhosis. A considerable number of eosinophils were found in the portal tracts in 51 of these specimens (29%), whereas this finding occurred in only 2 of 50 (4%) specimens from patients with viral chronic active hepatitis. Eosinophilic infiltration of the portal tracts was focal.

Irwin M. Arias, Mingxin Che, Zenaida Gatmaitan, Cynthia Leveille, Toshirou Nishida, Marie St. Pierre – 1 February 1993

1 February 1993

Hui‐Cheng Cheng, Chuen‐May Yang, Ming‐Shi Shiao – 1 February 1993 – Hepatic zonation of cholesterol and glycerolipid synthesis was investigated in regenerating rat livers 24 hr after partial hepatectomy. Tritiated acetate and [U‐14Clglycerol were injected into rats' peritoneal cavities for a short‐term labeling study. Periportal and perivenous hepatocytes were isolated by digitonin collagenase perfusion. Cholesterol synthesis was significantly higher in periportal hepatocytes of the sham‐operated livers (periportal/perivenous = 1.67; p < 0.05).

Daphna Fenyves, Louise Gariépy, Jean‐Pierre Villeneuve – 1 February 1993 – To delineate the factors responsible for impaired clearance in cirrhosis, we examined propranolol disposition in rats with carbon tetrachloride–induced cirrhosis and compared it with that in control animals, rats treated with chlorpromazine (an inhibitor of propranolol metabolism) and rats with acute liver injury. We measured the extraction ratio of propranolol by the isolated perfused liver and related it to estimates of propranolol drug‐metabolizing enzyme activity in homogenates of the same livers.