Redundant Functions of ERK1 and ERK2 Maintain Mouse Liver Homeostasis Through Down‐Regulation of Bile Acid Synthesis

Francesca Cingolani, Yunshan Liu, Yang Shen, Jing Wen, Alton B. Farris, Mark J. Czaja – 21 December 2021 – Activation of extracellular signal–regulated kinase (ERK) 1/2 promotes hepatocyte proliferation in response to growth stimuli, but whether constitutive hepatocyte ERK1/2 signaling functions in liver physiology is unknown. To examine the role of ERK1/2 in hepatic homeostasis, the effects of a knockout of Erk1 and/or Erk2 in mouse liver were examined. The livers of mice with a global Erk1 knockout or a tamoxifen‐inducible, hepatocyte‐specific Erk2 knockout were normal.

Immunological alterations after immunotherapy with short lived HBV‐TCR T cells associates with long‐term treatment response in HBV‐HCC

Anthony Tanoto Tan, Fanping Meng, Jiehua Jin, Ji‐Yuan Zhang, Si‐Yu Wang, Lei Shi, Ming Shi, Yuanyuan Li, Yunbo Xie, Li‐Min Liu, Chun‐Bao Zhou, Alicia Chua, Zi Zong Ho, Junqing Luan, Jinfang Zhao, Jing Li, Lu‐En Wai, Sarene Koh, Tingting Wang, Antonio Bertoletti, Fu‐sheng Wang – 20 December 2021 – The application of hepatitis B virus (HBV)–T‐cell receptor (TCR) T‐cell immunotherapy in patients with HBV‐related hepatocellular carcinoma (HBV‐HCC) has been apathetic, as the expression of HBV antigens by both normal HBV‐infected hepatocytes and HCC cells with HBV‐DNA integration increases the ri

Alcohol Consumption and Cardiovascular Outcomes in Patients With Nonalcoholic Fatty Liver Disease: A Population‐Based Cohort Study

Malik Janjua, Matthew Knuiman, Mark Divitini, Brendan McQuillan, John K. Olynyk, Gary P. Jeffrey, Leon A. Adams – 19 December 2021 – Low‐level alcohol consumption is associated with reduced cardiovascular disease (CVD) in the general population. It is unclear whether this association is seen in patients with nonalcoholic fatty liver disease (NAFLD) who have an increased risk of CVD. We examined the association between alcohol consumption and CVD‐related outcomes in subjects with NAFLD from a general population cohort.

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