Personalizing Diabetes Management in Liver Transplant Recipients: The New Era for Optimizing Risk Management

Brooks Richardson, Mohammad Qasim Khan, Sara A Brown, Kymberly D Watt, Manhal Izzy – 16 December 2021 – Post‐transplant diabetes mellitus (PTDM) is a significant contributor to morbidity and mortality in liver transplant recipients (LTRs). With concurrent comorbidities and use of various immunosuppression medications, identifying a safe and personalized regimen for management of PTDM is needed. There are many comorbidities associated with the post‐transplant course including chronic kidney disease, cardiovascular disease, allograft steatosis, obesity, and de novo malignancy.

Decreased Long‐Term Severe Acute Respiratory Syndrome Coronavirus 2–Specific Humoral Immunity in Liver Transplantation Recipients 12 Months After Coronavirus Disease 2019

Aránzazu Caballero‐Marcos, María Jesús Citores, Roberto Alonso‐Fernández, Manuel Rodríguez‐Perálvarez, Maricela Valerio, Javier Graus Morales, Valentín Cuervas‐Mons, Alba Cachero, Carmelo Loinaz‐Segurola, Mercedes Iñarrairaegui, Lluís Castells, Sonia Pascual, Carmen Vinaixa‐Aunés, Rocío González‐Grande, Alejandra Otero, Santiago Tomé, Javier Tejedor‐Tejada, Ainhoa Fernández‐Yunquera, Luisa González‐Diéguez, Flor Nogueras‐Lopez, Gerardo Blanco‐Fernández, Fernando Díaz‐Fontenla, Francisco Javier Bustamante, Mario Romero‐Cristóbal, Rosa Martin‐Mateos, Ana Arias‐Milla, Laura Calatayud, Alberto

Low Levels of Hepatocyte‐Specific Methylation in Cell‐Free DNA Are a Strong Negative Predictor for Acute T Cell–Mediated Rejection Requiring Treatment Following Liver Transplantation

Daniel R. A. Cox, Nicholas Low, Su Kah Goh, Eunice Lee, Angela Vago, Louise Jackett, Julie Lokan, Sabine Braat, Robert Jones, Adam Testro, Alexander Dobrovic, Vijayaragavan Muralidharan – 15 December 2021 – Graft‐derived cell‐free DNA (gdcfDNA) quantification is a promising, minimally invasive tool for detecting acute T cell–mediated rejection (ATCMR) following liver transplantation (LT). We investigated the utility of measuring hepatocyte‐specific methylation in cfDNA (HS‐cfDNA) to quantify gdcfDNA, examining its accuracy in detecting ATCMR in a prospective, cross‐sectional study.

Prediction of biochemical nonresolution in patients with chronic drug‐induced liver injury: A large multicenter study

Chun‐Yan Wang, Ya Deng, Ping Li, Sujun Zheng, Guofeng Chen, Guangde Zhou, Jing Xu, Yan‐Ping Chen, Zheng Wang, Xueyuan Jin, Jin‐Mo Tang, Kun‐Peng Hu, Jing‐Feng Bi, Ping Zhang, Chun‐Xia Li, Ang Huang, Gui‐Ji Lv, Xiao‐He Xiao, Zhengsheng Zou, Dong Ji – 15 December 2021

Sirolimus or Everolimus Improves Survival After Liver Transplantation for Hepatocellular Carcinoma: A Systematic Review and Meta‐Analysis

Xiangyu Yan, Songhan Huang, Yang Yang, Ziwen Lu, Feiyu Li, Liyong Jiang, Yong Jiang, Jun Liu – 15 December 2021 – The effects of mammalian target of rapamycin (mTOR) inhibitors (sirolimus [SRL] and everolimus [EVL]) on survival in liver transplantation (LT) recipients with hepatocellular carcinoma (HCC) remain the subject of intense research. Therefore, we performed this systematic review and meta‐analysis to investigate the potential survival benefits of mTOR inhibitors (mTORis).

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