North American Biliary Stricture Management Strategies in Children After Liver Transplantation: A Multicenter Analysis From the Society of Pediatric Liver Transplantation (SPLIT) Registry

Pamela L. Valentino, Tianhao Wang, Veronika Shabanova, Vicky Lee Ng, John C. Bucuvalas, Amy G. Feldman, Regino P. Gonzalez‐Peralta, Nitika Arora Gupta, Tamir A. Miloh, Saeed Mohammad, Erika Pace, Shikha S. Sundaram, Nada A. Yazigi, Kyle Soltys, Society of Pediatric Liver Transplantation (SPLIT) – 26 November 2021 – Biliary strictures affect 4%‐12% of pediatric liver transplantations. Biliary strictures can contribute to graft loss if left untreated; however, there remains no consensus on the best course of treatment.

Clusterin and Related Scoring Index as Potential Early Predictors of Response to Sorafenib in Hepatocellular Carcinoma

Satoshi Narahara, Takehisa Watanabe, Katsuya Nagaoka, Nahoko Fujimoto, Yoki Furuta, Kentaro Tanaka, Takayuki Tokunaga, Takeshi Kawasaki, Yoko Yoshimaru, Hiroko Setoyama, Kentaro Oniki, Junji Saruwatari, Masakuni Tateyama, Hideaki Naoe, Motohiko Tanaka, Yasuhito Tanaka, Yutaka Sasaki – 26 November 2021 – Advanced hepatocellular carcinoma (HCC) remains a highly lethal malignancy, although several systemic therapeutic options are available, including sorafenib (SFN), which has been one of the standard treatment agents for almost a decade.

Burnout Among Transplant Hepatologists in the United States

Kamron Pourmand, Thomas D. Schiano, Yash Motwani, Michael Kriss, Laurie Keefer, Arpan Patel – 25 November 2021 – Burnout among transplant hepatologists has not been well characterized. The goal of this study was to describe the prevalence and predictors of burnout among practicing transplant hepatologists in the United States. We designed a 69‐item survey, including the Maslach Burnout Inventory (MBI)–Human Services Survey and questions on provider demographics, practice characteristics, and psychological factors.

TGFβ‐induced FOXS1 controls epithelial–mesenchymal transition and predicts a poor prognosis in liver cancer

Kevin Bévant, Matthis Desoteux, Gaëlle Angenard, Raphaël Pineau, Stefano Caruso, Corentin Louis, Panagiotis Papoutsoglou, Laurent Sulpice, David Gilot, Jessica Zucman‐Rossi, Cédric Coulouarn – 25 November 2021 – Transforming growth factor beta (TGF‐β) plays a key role in tumor progression, notably as a potent inducer of epithelial–mesenchymal transition (EMT). However, all of the molecular effectors driving TGFβ‐induced EMT are not fully characterized.

High‐Resolution Exposomics and Metabolomics Reveals Specific Associations in Cholestatic Liver Diseases

Douglas I. Walker, Brian D. Juran, Angela C. Cheung, Erik M. Schlicht, Yongliang Liang, Megan Niedzwiecki, Nicholas F. LaRusso, Gregory J. Gores, Dean P. Jones, Gary W. Miller, Konstantinos N. Lazaridis – 25 November 2021 – Progress in development of prognostic and therapeutic options for the rare cholestatic liver diseases, primary sclerosing cholangitis (PSC) and primary biliary cholangitis (PBC), is hampered by limited knowledge of their pathogeneses.

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