Enhanced autoreactivity of T‐lymphocytes in primary sclerosing cholangitis

Keith D. Lindor, Russell H. Wiesner, Nicholas F. Larusso, Henry A. Homburger – 1 September 1987 – Primary sclerosing cholangitis is a chronic, cholestatic liver disease in which immune mechanisms are thought to play a role in the pathogenesis. We have determined the frequencies and functional phenotypes of autoreactive T‐lymphocytes in peripheral blood specimens from patients with primary sclerosing cholangitis and healthy adults as an indicator of autoreactivity in primary sclerosing cholangitis.

Bile salt shift from albumin to high‐density lipoprotein in cholestasis

Hans‐Peter Buscher, Mathias Beger, Hella Sauerbier, Wolfgang Gerok – 1 September 1987 – The distribution of [3H]taurocholate between albumin and the lipoproteins of serum of patients with various diseases in which lipoprotein metabolism and/or bile salt concentrations were altered and of healthy control subjects was investigated by means of the density gradient centrifugation method. 1In control sera, bile salts distribute mainly between albumin and high‐density lipoprotein.

A population study on the prevalence of gallstone disease: The sirmione study

Luigi Barbara, Claudia Sama, Antonio Maria Morselli Labate, Francesco Taroni, Anna Giulia Rusticali, Davide Festi, Carlo Sapio, Enrico Roda, Claudio Banterle, Armando Puci, Franco Formentini, Silvia Colasanti, Francesco Nardin – 1 September 1987 – The prevalence of gallstone disease (cholelithiasis and previous cholecystectomy for gallstones) in the population of the town of Sirmione, Italy, examined by ultrasonography, was 6.7% in men and 14.6% in women, ranging from 18 to 65 yr of age (overall prevalence = 11%).

Diminished serum Gc (vitamin D‐binding protein) levels and increased Gc:G‐actin complexes in a hamster model of fulminant hepatic necrosis

William M. Lee, David L. Emerson, William O. Young, Pascal J. Goldschmidt‐Clermont, David J. Jollow, Robert M. Galbraith – 1 September 1987 – Evidence for increased plasma levels of complexes containing Gc (vitamin D‐binding protein) and cellular actin has been previously reported during fulminant hepatic necrosis in man. In order to study this process in more detail, we produced liver injury in hamsters using increasing doses of acetaminophen, with serial collection of sera for up to 168 hr after acetaminophen injection.

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