Evidence for the cell‐surface localization of antigens cross‐reacting with the “mitochondrial antibodies” of primary biliary cirrhosis

Iraj Ghadiminejad, Harold Baum – 1 July 1987 – Studies with subfractions of Saccharomyces cerevisiae obtained by differential centrifugation showed only two primary biliary cirrhosis‐specific antigens. These antigenic species were shown, using preabsorption studies, to have determinants cross‐reactive with their mammalian counterpart

The effect of recombinant α‐interferon treatment on serum levels of hepatitis B virus‐encoded proteins in man

Georg Hess, Wolfram Gerlich, Guido Gerken, Michael Manns, Thomas H. Hütteroth, Karl‐Hermann Meyer Zum Büschenfelde – 1 July 1987 – The effect of α‐interferon treatment on serum levels of hepatitis B virus‐encoded proteins was analyzed in eight patients with chronic type B hepatitis who participated in a pilot study of interferon therapy. Three individuals became HBsAg‐negative, 4 lost HBeAg but remained HBsAg‐positive and 1 remained positive for both HBsAg and HBeAg.

Aflatoxin content of foods served to a population with a high incidence of hepatocellular carcinoma

Ghanshyam Lohiya, Laura Nichols, Dennis Hsieh, Sunita Lohiya, Hoan Nguyen – 1 July 1987 – During three seasons, 36 samples of foods served to mentally retarded clients with a high incidence of hepatocellular carcinoma were analyzed for aflatoxin. Aflatoxin was not detected (less than 5 ppb) by thinlayer liquid chromatography in 35 food samples containing peanuts, corn, wheat or milk. One peanut butter sample contained 20 ppb aflatoxin. Aflatoxin content of these foods was at or below the level permitted by the Food and Drug Administration.

Identification and characterization of liver nonparenchymal cells by flow cytometry

Mark Doolittle, Roger Bohman, Andres Durstenfeld, Joseph Cascarano – 1 July 1987 – Our objective was to correlate biochemical or functional properties that could be measured by fluorescence to individual nonparenchymal cell types by the simultaneous detection of forward angle light scatter and fluorescence. Cells were released from liver following selective digestion of hepatocytes by Pronase perfusion. To fractionate the cells according to size, isolates were subjected to unit gravity sedimentation on a 1 to 5% sucrose gradient.

Acute and chronic hemodynamic effects of propranolol in unselected cirrhotic patients

Julio Vorobioff, Eduardo Picabea, Roberto Villavicencio, Viviana Puccini, Oscar Rossi, Juan Bordato, Marcelo Audano – 1 July 1987 – Different and contradictory results concerning the use of propranolol in the treatment of portal hypertension have been reported. This study was designed to investigate the hemodynamic effects of short‐ and long‐term administration of propranolol in portal hypertensive patients.

Epiphenomenology and the gallbladder: Several examples

Mary E. Charlson – 1 July 1987 – It has been suggested that gallbladder removal may protect against subsequent development of myocardial infarction because of increased gastrointestinal cholesterol excretion resulting from increased enterohepatic cycling. To test this hypothesis, the authors used data from two large case‐control studies of myocardial infarction–‐one conducted in 1976–1979 in 155 US hospitals and one conducted in 1980–1983 in 78 US hospitals. First, 550 female myocardial infarction cases were compared to 1,658 controls.

Auricular pressure in the treatment of gallstones: A randomized, clinical trial of traditional chinese medicine

Xiening Wu – 1 July 1987 – Gallstones, which were diagnosed in 365 patients on the basis of symptoms, signs, ultrasound scanning and cholecystography were treated by compression of specific auricular points. The patients were predominantly women (76%) from 19 to 78 years of age. The stones were in the gallbladder in 326, in intrahepatic ducts in 20, in the common bile duct in 6 and at multiple sites in 14.

Immunohistochemical distribution of renal prostaglandin endoperoxide synthase and prostacyclin synthase: Diminished endoperoxide synthase in the hepatorenal syndrome

Sugantha Govindarajan, Cynthia C. Nast, William L. Smith, Martin A. Koyle, George Daskalopoulos, Robert D. Zipser – 1 July 1987 – To evaluate possible causes of the diminished prostaglandin production in advanced hepatorenal syndrome, prostaglandin endoperoxide synthase and prostacyclin synthase were localized and semiquantitated by immunofluorescence in postmortem, biopsy and nephrectomy renal tissues. In normal kidneys, antiprostacyclin synthase serum caused intense staining in peritubular capillaries, in the adjacent renal interstitial cells and in glomerular mesangial regions.

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