GÜL Bakti, Hans U. Fisch, Georg Karlaganis, Christoph Minder, Johannes Bircher – 1 July 1987 – Mechanisms responsible for disproportional sedation resulting from triazolam administration to patients with cirrhosis were investigated. Ordinary sedative doses (0.25 mg) were given p.o. to 8 cirrhotics and 18 controls. Plasma concentrations of unbound drug were assessed by capillary gas chromatography and equilibrium dialysis. Median apparent oral clearances of unbound triazolam were 14.8 ml per min per kg in cirrhotics and 23.9 ml per min per kg in controls (p < 0.01).

Lawrie W. Powell – 1 July 1987 – Electron microscopic studies of acidophilic or Councilman‐like bodies in the liver show that they are manifestations of apoptosis. The morphology and biochemistry of apoptosis suggest a process of active cellular self‐destruction rather than degeneration. The incidence of apoptosis indicates that it is normally involved in the regulation of organ size and, in addition, may be triggered by specific pathological stimuli. Cell death produced in vitro by various types of cell‐mediated immune injury occurs by apoptosis

Jay H. Hoofnagle, David A. Shafritz, Hans Popper – 1 July 1987

Patricia L. Marion, John M. Cullen, Roberto R. Azcárraga, Mary Jo Van Davelaar, William S. Robinson – 1 July 1987 – We investigated experimental transmission of duck hepatitis B virus to its original host, the domestic Pekin duck, and to three other avian species.

Danielle P. Praaning‐Van Dalen, A. Margreet De Leeuw, A. Brouwer, Dick L. Knook – 1 July 1987 – The capacity of rat liver Kupffer and endothelial cells to endocytose glycoproteins with N‐acetylglucosamine‐or mannose‐terminated oligosaccharide chains was studied. For this purpose, agalactoorosomucoid, ahexo‐saminoorosomucoid and horseradish peroxidase were used as ligands. A reliable determination of the amount of ligand endocytosed in vivo or in vitro was made possible by using the recently developed cold pronase method for the isolation and purification of Kupffer and endothelial cells.

1 July 1987

Charles F. Gholson, Michael R. Freeman, Ricardo Mastai, Jaime Bosch, Robin D. Hughes, Roger Williams, David G. Parsons – 1 July 1987

Robert A. Branch – 1 July 1987

J. A. McDonald, L. Caruso, P. Karayiannis, L. J. Scully, J. R. W. Harris, G. E. Forster, H. C. Thomas – 1 July 1987 – In a randomized controlled trial, 41 chronic hepatitis B virus carriers were allocated, by opening numbered computerized randomization envelopes, to receive recombinant interferon‐α2A at three different doses: 2.5; 5.0, and 10.0 mU per m2. Thirty‐two patients received treatment (6 for 3 months, 26 for 6 months), and 9 patients were controls (received no treatment). Ninety‐three per cent of our patients were homosexual, and 41% had anti‐HTLV‐III in their serum

Myron J. Tong, Richard E. Sampliner, Sugantha Govindarajan, Ruth L. Co – 1 July 1987 – Eleven patients of Chinese origin experienced spontaneous reactivation of chronic active hepatitis B. Eight HBsAg‐positive patients were followed for an average of 15 months prior to, while three others presented during reactivation. Fatigue, hepatomegaly and jaundice were frequent findings. Elevation of both serum ALT (average = 1,212 units per liter) and hepatitis B virus DNA levels were noted in all patients, and reactivation lasted an average of 4.4 months.