Peter Van Der Sluijs, Bart Postema, Dirk K. F. Meijer – 1 July 1987 – Two types of models have recently been proposed to describe hepatic uptake kinetics of protein bound drugs: a model in which dissociation from plasma protein is rate limiting the process, and a model in which an interaction between protein and hepatocyte surface is thought to promote dissociation and uptake of the drug. This study was designed to investigate several aspects of both models, using lactosylated albumin as a binding protein that can interact with the Ashwell receptor abundantly present on the hepatocyte.

Claire Infante‐Rivard, Santiago Esnaola, Jean‐Pierre Villeneuve – 1 July 1987 – The objective of this study was to assess the prognostic validity of Child‐Turcotte classification with regard to short‐term (1‐year) survival. The Child‐Turcotte classification, as modified by Pugh et al., was recorded on admission in 177 cirrhotic patients. The variables that comprise the Pugh modification are ascites, encephalopathy, serum albumin, serum bilirubin and prothrombin time.

George J. Brewer – 1 May 1987

Marvin A. Lipsky, John L. Gollan – 1 May 1987

Kazuhiko Koike, Shiro Iino, Kiyohiko Kurai, Keiji Mitamura, Yasuo Endo, Hiroshi Oka – 1 May 1987 – IgM anti‐HBc was measured by radioimmunoassay in serially collected serum samples during 20 acute exacerbations which developed in 14 patients with anti‐HBe positive chronic type B hepatitis. IgM anti‐HBc became positive in 12 of the 14 (86%) patients and in 18 of the 20 (90%) exacerbations, and elevation of IgM anti‐HBc which was believed to be significant was also observed in the remaining two patients.

Sum P. Lee, Cliff Tasman‐Jones, Valerie F. Carlisle – 1 May 1987 – Rabbits fed a diet rich in oleic acid develop gallstones consisting of calcium salts of (5α)‐glyco‐allodeoxycholic acid. To study the metabolic pathway of oleic acid, we followed the changes in plasma, hepatic and biliary lip‐ids in this animal model. In addition, to also determine the role played by intestinal microflora on biliary lipid metabolism, we added kanamycin to the oleic acid diet. Oleic acid‐fed rabbits rapidly developed hypercholes‐terolemia.

Carmen De Lemos‐Chiarandini, Fernando Alvarez, Olivier Bernard, Jean Claude Homberg, Gert Kreibich – 1 May 1987 – Human sera, containing anti‐liver‐kidney microsome antibody as demonstrated by indirect immunofluorescence, were obtained from a subgroup of young patients with autoimmune chronic hepatitis. The anti‐liver‐kidney microsome antibody‐positive sera were used to study the localization of the liver‐kidney microsome antigen in hepatocytes.

Alfred L. Baker, Patricia S. Krager, Alvin N. Kotake, Dale A. Schoeller – 1 May 1987 – To determine whether the aminopyrine breath test can be used to document the presence of cirrhosis in patients with cholestatic liver disease, 19 patients (13 primary biliary cirrhosis, 4 sclerosing cholangitis and 2 chronic extrahepatic bile duct obstruction) underwent clinical and biochemical evaluations, liver biopsies and an aminopyrine breath test. Results were compared with those in 10 patients with biopsy‐proven chronic active hepatitis with bridging and/or cirrhosis and in 22 healthy subjects.

Shorland W. Hosking, Hugh J. Kennedy, Ian Seddon, David R. Triger – 1 May 1987 – Heavy diffuse bleeding from congested gastric mucosa (congestive gastropathy) was treated by propranolol (dose = 24 to 480 mg per day) in 14 consecutive patients with portal hypertension. Thirteen patients (93%) stopped bleeding within 3 days. Gastric mucosal cherry red spots (a sign of severe gastropathy) were unchanged in 5 patients, became less obvious in 4 and appearances returned to normal in 5.

1 May 1987