FM ultrasonography: A revolution?

Peter N. Burns, Lynwood Hammers – 1 November 1987 – FM sonography—a signal‐processing technique that uses frequency and phase information as well as amplitude data—shows promise in evaluation of patients with diffuse liver disease. In a prospective blinded review of 37 patients with biopsyproved liver disease and 42 healthy volunteers, FM sonography was clearly superior to traditional amplitude‐based (AM) sonography in distinguishing healthy from diseased subjects.

Hepatic heme synthesis in a new model of experimental hemochromatosis: Studies in rats fed finely divided elemental iron

Herbert L. Bonkovsky, John F. Healey, Beth Lincoln, Bruce R. Bacon, David F. Bishop, George H. Elder – 1 November 1987 – Rats fed chow containing finely divided elemental iron (from carbonyl‐iron) develop hepatic iron overload resembling human hereditary hemochromatosis in that deposition of iron is primarily in periportal hepatocytes and with hepatic iron concentrations sufficiently high to be associated in the human disease with hepatic fibrosis or cirrhosis.

Mucus hypersecretion in the gallbladder epithelium of ground squirrels fed a lithogenic diet for the induction of cholesterol gallstones

Ramjeet S. Pemsingh, Brian R. Macpherson, Gerald W. Scott – 1 November 1987 – This study identified mucus granules, determined mode of release and quantified their volume in the gallbladder epithelium of Richardson's ground squirrels (Spermophilus richardsonii) fed a lithogenic diet of 2% cholesterol to experimentally induce gallstone formation. Tissue was examined using light microscopy histochemistry, scanning and transmission electron microscopy, as well as autoradiography and morphometry at the electron microscopic level.

Effect of colchicine and phalloidin on the distribution of three plasma membrane antigens in rat hepatocytes: Comparison with bile duct ligation

Anne‐Marie Durand‐Schneider, Michèle Maurice, Micheline Dumont, Gérard Feldmann – 1 November 1987 – The hepatocyte plasma membrane presents a morphological and functional regionalization into three domains: the sinusoidal; the lateral, and the canalicular. The mechanisms responsible for the biogenesis and maintenance of this regionalization are poorly understood. In this work, we have used colchicine and phalloidin, two drugs known to interfere with the secretory processes in hepatocytes, to study whether they also affect the transport of membrane proteins.

Bile canalicular morphometry in arteriohepatic dysplasia

C. L. Witzleben, Milton Finegold, David A. Piccoli, William R. Treem – 1 November 1987 – The diagnosis of arteriohepatic dysplasia may be difficult, particularly in very young patients with no family history, and the pathogenesis of the disorder remains obscure. It has been reported that the typical ultrastructural changes of cholestasis are scant in this condition and proposed that there is a failure of the hepatocytes to secrete bile into the canaliculi.

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