Shorland W. Hosking, Hugh J. Kennedy, Ian Seddon, David R. Triger – 1 May 1987 – Heavy diffuse bleeding from congested gastric mucosa (congestive gastropathy) was treated by propranolol (dose = 24 to 480 mg per day) in 14 consecutive patients with portal hypertension. Thirteen patients (93%) stopped bleeding within 3 days. Gastric mucosal cherry red spots (a sign of severe gastropathy) were unchanged in 5 patients, became less obvious in 4 and appearances returned to normal in 5.

1 May 1987

Sergio Gammal, David Geller – 1 May 1987

J. W. Grisham – 1 May 1987

Karl H. Wiedmann, Ludwik K. Trejdosiewicz, Jennifer Southgate, Howard C. Thomas – 1 May 1987 – Monoclonal antibodies were isolated following immunization with the HBsAg and α‐fetoprotein‐secreting human hepatoma PLC/PRF/5 (“Alexander”) cell line. Three antibodies (K‐PLC1, K‐PLC2 and K‐PLC3) showed evidence of carcinoma‐associated reactivity by indirect immunofluorescence. Antibodies K‐PLC2 and K‐PLC3 reacted only with PLC/PRF/5 cells, but not with any other normal or malignant cell type tested, including the Hep/G2 hepatoma cell line.

Ibrahim M. Yousef, Stephen G. Barnwell, Beatriz Tuchweber, Andrée Weber, Claude C. Roy – 1 May 1987 – The effect of sulfation of common bile acids on the formation of bile was investigated in male rats by infusing them with the sulfate esters of cholic, chenodeoxycholic, deoxycholic, lithocholic or dehydrocholic acid in four step‐wise, increasing doses. Each dose was infused for 30 min and bile collected every 10 min.

Thierry Poynard, Didier Lebrec, Patrick Hillon, Raymond Sayegh, Jacques Bernuau, Sylvie Naveau, Jean‐Claude Chaput, Claude Klepping, Bernard Rueff, Jean‐Pierre Benhamou – 1 May 1987 – In a previous randomized trial, we demonstrated that propranolol prevented recurrent gastrointestinal bleeding in patients with cirrhosis. We have undertaken the present study in a new group of patients to ascertain the factors associated with rebleeding. Among 232 patients with cirrhosis admitted for gastrointestinal bleeding, 127 were included.

Douglas M. Simon, J. Ross McCain, Herbert L. Bonkovsky, James O. Wells, Diane K. Hartle, John T. Galambos – 1 May 1987 – Thirteen patients with cirrhosis and tense ascites (six with and seven without peripheral edema) underwent 4‐ to 15‐liter paracentesis without intravenous “colloid” replacement. Cardiac output increased from 6.6 ± 0.7 liters per min at baseline to 8.2 ± 0.7 liters per min (p < 0.003) 1 hr after large‐volume paracentesis completion and fell to 7.5 ± 0.69 liters per min (p < 0.05 vs. baseline, p < 0.02 vs. 1 hr) 24 hr after large‐volume paracentesis completion.

Charles S. Lieber – 1 May 1987

Akihiko Fuji, Shinichi Kakumu, Yoshiyuki Ohtani, Kenichi Murase, Hideo Hirofuji, Hirofumi Tahara – 1 May 1987 – We investigated the role of the interferon system in the pathogenesis of chronic liver disease. Interferon‐γ production by peripheral blood mononuclear cells was measured with an ELISA.