Gretchen M. Hill, George J. Brewer, Ananda S. Prasad, Connie R. Hydrick, Deborah E. Hartmann – 1 May 1987 – The standard therapy for preventing copper accumulation in Wilson's disease, D‐penicillamine, has been a life‐saving drug, but it has many side effects and some patients are completely intolerant. We have been using oral zinc as another approach to the therapy for Wilson's disease, with copper balance studies as the key initial assessment of the adequacy of a given dose or regimen of zinc therapy.

Esteban Celis, Katalin G. Abraham, Richard W. Miller – 1 May 1987 – Antibodies to HBsAg of IgG class enhanced the helper activity of a human T cell clone to promote the in vitro synthesis of immunoglobulins by autologous B lymphocytes. Using two different assay systems, the effect of antigen‐specific antibodies on the helper function of a HBsAg‐reactive T cell clone was studied. The monoclonal antibody to HBsAg A5C3 (IgG) increased significantly the T cell‐dependent production of immunoglobulins by Staphyloccocus aureus‐stimulated autologous B lymphocytes.

Maria H. Sjogren, Jay H. Hoofnagle, Jeanne G. Waggoner – 1 May 1987 – Serum levels of antibody to hepatitis B core antigen and IgM antibody to hepatitis B core antigen were tested in 15 patients who participated in a randomized, placebo‐controlled trial of a 28‐day course of prednisolone therapy. During treatment, serum levels of antibody to hepatitis B core antigen and IgM antibody to hepatitis B core antigen decreased in all 10 treated patients, but in none of five controls (p < 0.05).

Lawrence Deckelbaum – 1 May 1987 – Patients with obstructive jaundice are susceptible to postoperative shock and kidney failure. The cause of these potentially fatal complications has not been fully clarified. The present study was designed to assess the role of myocardial dysfunction in the hemodynamic disturbance of obstructive jaundice. We studied the effect of isolated cholemia on left ventricular performance in five conscious dogs before and 2 weeks after choledochocaval anastomosis by using measurements of systolic time intervals (STIs) and maximal dp/dt.

James S. Morgan, Harold O. Conn – 1 May 1987

Adrian Reuben – 1 May 1987

Kevin D. Mullen – 1 May 1987

Dennis R. Feller, Yogendra Singh, Vilas R. Shirhatti, Thomas A. Kocarek, Cuo‐Tung Liu, Gopal Krishna – 1 May 1987 – We have determined the comparative activities of peroxisomal proliferators, ciprofibrate and clofibric acid on various hepatic parameters associated with endoplasmic reticulum, mitochondria and peroxisomes in primary cultures of rat hepatocytes.

Christopher K. Daniels, Douglas L. Schmucker – 1 May 1987 – The source and significance of immunoglobulin A in bile remains controversial. In the rat, and several other species, immunoglobulin A is transported through hep‐atocytes by a specific receptor, secretory component. In humans, immunohistochemical methods have indicated a distinct lack of receptors for immunoglobulin A on hepatocytes. Binding assays with 125I‐immunoglobulin A and membranes from hepatocytes and intestinal cells of the rat display secretory component‐dependent binding.

Tastuo Murakami, Hirohisa Yano, Masafumi Maruiwa, Shigetaka Sugihara, Masamichi Kojiro – 1 May 1987 – A human cell line (KMCH‐1) derived from a surgical specimen of combined hepatocellular and cholangiocarcinoma has been established. The original tumor consisted of both hepatocellular carcinoma of the trabecular type and cholangiocellular carcinoma. This cell line has been maintained for 26 months through 75 passages. KMCH‐1 cells show characteristics of adenocarcinoma on light and electron microscopy. They proliferate in culture in a pave stone arrangement.