Surrogate tests and the risk of posttransfusion hepatitis; their time has come

Richard D. Aach – 1 May 1987 – A total of 481 recipients of blood transfusions who had received 6,295 units of blood were followed for 6–9 months in order to evaluate the relationship between posttransfusion hepatitis (PTH) and transfusion of blood that is positive for antibody to hepatitis B core antigen (anti‐HBc). The incidence of non‐A, non‐B PTH (NANB‐PTH) was 11.9% among the 193 recipients who received one or more units of anti‐HBc‐positive blood compared to only 3.2% of the 288 recipients of only anti‐HBc‐negative blood (p < 0.001).

Liver transplantation across abo blood groups

Joseph R. Bove, Harold O. Conn – 1 May 1987 – Six hundred seventy‐one first, second and third orthotopic liver allografts in 520 patients were reviewed to determine the effect of donor‐recipient mismatches or incompatibilities for the ABO blood groups on graft survival. A significant advantage for ABO donor‐recipient identity was found, especially in adults for first grafts. However, a surprisingly large number of ABO incompatible grafts were successful.

Role of acetaldehyde in the ethanol‐induced impairment of hepatic glycoprotein secretion in the rat In vivo

Gary D. Volentine, Kathleen A. Ogden, David K. Kortje, Dean J. Tuma, Michael F. Sorrell – 1 May 1987 – Ethanol administration inhibits hepatic protein and glycoprotein secretion. Previous studies have shown that the metabolism of ethanol is required for this effect. Experiments were designed to determine whether acetaldehyde, the first metabolite of ethanol oxidation, mediated the ethanol‐induced secretory defect in rats with normal and stimulated (inflammation‐induced) rates of hepatic protein secretion.

Orthotopic liver transplantation for acute and subacute hepatic failure in adults

Rene R. Peleman, Judith S. Gavaler, David H. Van Thiel, Carlos Esquivel, Robert Gordon, Shunzaburo Iwatsuki, Thomas E. Starzl – 1 May 1987 – The role of liver transplantation in 29 patients with fulminant and subacute hepatic failure due to a variety of different causes was examined by comparing the outcome and a variety of “hospitalization” variables. Transplanted patients (n = 13) were more likely to survive (p < 0.05), were younger (p < 0.05) and spent more time in the hospital (p < 0.025) than did those who were not transplanted (n = 16).

The acute vanishing bile duct syndrome (acute irreversible rejection) after orthotopic liver transplantation

Jurgen Ludwig, Russell H. Wiesner, Kenneth P. Batts, James D. Perkins, Ruud A. F. Krom – 1 May 1987 – The acute vanishing bile duct syndrome can be defined as an irreversible, rejection‐related condition that affects hepatic allografts within 100 days after orthotopic liver transplantation and whose presence requires retransplantation. We have observed the acute vanishing bile duct syndrome in 5 of 48 consecutive patients (approximately 10%) who underwent orthotopic liver transplantation.

Endoscopic sclerotherapy with portal‐systemic shunt rescue

Harold O. Conn – 1 May 1987 – This paper reports the preliminary results of a prospective randomized trial comparing endoscopic variceal sclerosis and distal splenorenal shunt (DSRS) in the management of patients with cirrhosis and variceal bleeding. Seventy‐one patients have been entered; 36 have received sclerosis and 35 DSRS. Randomization of the study population was stratified on Child's A/B (56%) and Child's C (44%). Sixty‐one per cent had alcoholic and 39% nonalcoholic cirrhosis. No patients have been lost to follow‐up, which currently stands at a median of 26 months.

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