An extrahepatic bile duct growth factor: In vivo effect and preliminary characterization

Joy H. Glaser, Rachel Morecki, Sheila Fallon‐Friedlander, Marshall S. Horwitz – 1 March 1987 – Rabbit sera injected intraperitoneally into BALB/c mice were noted to produce a considerable and selective enlargement of extrahepatic bile ducts. The gallbladder, intrahepatic ducts, liver and other organs showed no stimulaion of growth. Duct enlargement leading to widening of its outer diameter which, on average, was 3.6 times that of normal, was due entirely to an increased number of epithelial cells with prominent proliferation of intramural glandular components.

Inflammatory pseudotumor of the liver: An enigmatic lesion with polyclonal plasma cell proliferation

Eric B. Larson – 1 March 1987 – Five cases of inflammatory pseudotumour of the liver are reported and compared with seven individual previously published case reports. Clinical presentation was variable but often comprised low grade intermittent fever, vague abdominal symptoms, and a history of weight loss. Leucocytosis, raised erythrocyte sedimentation rate, and polyclonal hyperglobulinaemia were also sometimes detected. All five cases in the present series were considered to be clinically malignant; and in two the histological diagnosis was also that of malignancy.

Hepatic metabolism during acute ethanol administration: A phosphorus‐31 nuclear magnetic resonance study on the perfused rat liver under normoxic or hypoxic conditions

Franck Desmoulin, Paul Canioni, Christian Crotte, André Gérolami, Patrick J. Cozzone – 1 March 1987 – The effect of ethanol metabolism on the energetic parameters and intracellular pH of the isolated perfused rat liver from fed rats was studied by phosphorus‐31 nuclear magnetic resonance spectroscopy. This technique allowed us to analyze nondestructively and in real time the role of low oxygen tension on the possible injurious effect of ethanol on the liver cells.

Characterization of desmin‐positive rat liver sinusoidal cells

Mikihiro Tsutsumi, Akira Takada, Shujiro Takase – 1 March 1987 – Hepatic sinusoidal lining cells were isolated from mature male rats (12 months old) and cultured in order to clarify the characteristics of the Ito cells (fat‐storing cells). Desmin staining was used as a marker in the isolation of the Ito cells, and a highly purified desmin‐positive cell fraction was obtained. Less than 10% of the desmin‐positive cells were positive for vitamin A auto‐fluorescence.

Bile acid transport: Lessons from the intestine

Richard H. Moseley – 1 March 1987 – The transport of bile acid was studied in basolateral membrane vesicles isolated from rat small intestine. Taurocholate transport into an osmotically reactive intravesicular space was Na+ independent. The uptake of taurocholate in jejunal and ileal vesicles preloaded with sulfate was stimulated with respect to uptake in unpreloaded vesicles. Glycocholate inhibited the transstimulation of taurocholate uptake by sulfate.

Liver levels of vitamin a and cellular retinol‐binding protein for patients wth biliary atresia

David E. Ong, Olivier Amédée‐Manesme – 1 March 1987 – We have examined whether the amount of cellular retinol‐binding protein in human liver is related to the amount of vitamin A stored in the liver. Levels of vitamin A, as retinol and retinol esters, and of cellular retinol‐binding protein have been determined in liver samples from 6 normal adults and 11 children with biliary atresia, with and without vitamin A treatment. The level of cellular retinol‐binding protein in the liver was not related to the liver vitamin A concentration examined over a 300‐fold range of vitamin A levels.

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