Francis A. Farraye, Jerome B. Zeldis – 1 May 1987 – Closed‐circular HBV DNA was introduced into cells of the established human hepatoma culture HepG2. The culture medium of one of 40 single‐cell clones contained HBV surface antigen (HBsAg), core‐related antigens (HBc/eAg), and HBV DNA sequences. HBV DNA and DNA polymerase activity were detected in particles resembling both nucleocapsids and complete virions (Dane particles). Intracellular integrated and extrachromosomal HBV DNA sequences were detected.

Howard A. Shapiro – 1 May 1987

Leslie Zieve – 1 May 1987

Eugene R. Schiff – 1 May 1987

John B. Gross, Juerg Reichen, Thomas B. Zeltner, Arthur Zimmermann – 1 May 1987 – The aim of this study was to determine the prognostic significance of functional changes in the liver during progression of cirrhosis. Liver function was quantitated weekly by the aminopyrine breath test (measuring microsomal function) and the galactose breath test (measuring cytosolic function) in rats made cirrhotic by bile duct ligation (n = 14) and in sham‐surgery controls (n = 9). Nine rats died spontaneously of cirrhosis.

Akihiko Fuji, Shinichi Kakumu, Yoshiyuki Ohtani, Kenichi Murase, Hideo Hirofuji, Hirofumi Tahara – 1 May 1987 – We investigated the role of the interferon system in the pathogenesis of chronic liver disease. Interferon‐γ production by peripheral blood mononuclear cells was measured with an ELISA.

Charles S. Lieber – 1 May 1987

Douglas M. Simon, J. Ross McCain, Herbert L. Bonkovsky, James O. Wells, Diane K. Hartle, John T. Galambos – 1 May 1987 – Thirteen patients with cirrhosis and tense ascites (six with and seven without peripheral edema) underwent 4‐ to 15‐liter paracentesis without intravenous “colloid” replacement. Cardiac output increased from 6.6 ± 0.7 liters per min at baseline to 8.2 ± 0.7 liters per min (p < 0.003) 1 hr after large‐volume paracentesis completion and fell to 7.5 ± 0.69 liters per min (p < 0.05 vs. baseline, p < 0.02 vs. 1 hr) 24 hr after large‐volume paracentesis completion.

Thierry Poynard, Didier Lebrec, Patrick Hillon, Raymond Sayegh, Jacques Bernuau, Sylvie Naveau, Jean‐Claude Chaput, Claude Klepping, Bernard Rueff, Jean‐Pierre Benhamou – 1 May 1987 – In a previous randomized trial, we demonstrated that propranolol prevented recurrent gastrointestinal bleeding in patients with cirrhosis. We have undertaken the present study in a new group of patients to ascertain the factors associated with rebleeding. Among 232 patients with cirrhosis admitted for gastrointestinal bleeding, 127 were included.

Ibrahim M. Yousef, Stephen G. Barnwell, Beatriz Tuchweber, Andrée Weber, Claude C. Roy – 1 May 1987 – The effect of sulfation of common bile acids on the formation of bile was investigated in male rats by infusing them with the sulfate esters of cholic, chenodeoxycholic, deoxycholic, lithocholic or dehydrocholic acid in four step‐wise, increasing doses. Each dose was infused for 30 min and bile collected every 10 min.