Thierry Poynard, Didier Lebrec, Patrick Hillon, Raymond Sayegh, Jacques Bernuau, Sylvie Naveau, Jean‐Claude Chaput, Claude Klepping, Bernard Rueff, Jean‐Pierre Benhamou – 1 May 1987 – In a previous randomized trial, we demonstrated that propranolol prevented recurrent gastrointestinal bleeding in patients with cirrhosis. We have undertaken the present study in a new group of patients to ascertain the factors associated with rebleeding. Among 232 patients with cirrhosis admitted for gastrointestinal bleeding, 127 were included.

Ibrahim M. Yousef, Stephen G. Barnwell, Beatriz Tuchweber, Andrée Weber, Claude C. Roy – 1 May 1987 – The effect of sulfation of common bile acids on the formation of bile was investigated in male rats by infusing them with the sulfate esters of cholic, chenodeoxycholic, deoxycholic, lithocholic or dehydrocholic acid in four step‐wise, increasing doses. Each dose was infused for 30 min and bile collected every 10 min.

Karl H. Wiedmann, Ludwik K. Trejdosiewicz, Jennifer Southgate, Howard C. Thomas – 1 May 1987 – Monoclonal antibodies were isolated following immunization with the HBsAg and α‐fetoprotein‐secreting human hepatoma PLC/PRF/5 (“Alexander”) cell line. Three antibodies (K‐PLC1, K‐PLC2 and K‐PLC3) showed evidence of carcinoma‐associated reactivity by indirect immunofluorescence. Antibodies K‐PLC2 and K‐PLC3 reacted only with PLC/PRF/5 cells, but not with any other normal or malignant cell type tested, including the Hep/G2 hepatoma cell line.

J. W. Grisham – 1 May 1987

Sergio Gammal, David Geller – 1 May 1987

1 May 1987

Shorland W. Hosking, Hugh J. Kennedy, Ian Seddon, David R. Triger – 1 May 1987 – Heavy diffuse bleeding from congested gastric mucosa (congestive gastropathy) was treated by propranolol (dose = 24 to 480 mg per day) in 14 consecutive patients with portal hypertension. Thirteen patients (93%) stopped bleeding within 3 days. Gastric mucosal cherry red spots (a sign of severe gastropathy) were unchanged in 5 patients, became less obvious in 4 and appearances returned to normal in 5.

Alfred L. Baker, Patricia S. Krager, Alvin N. Kotake, Dale A. Schoeller – 1 May 1987 – To determine whether the aminopyrine breath test can be used to document the presence of cirrhosis in patients with cholestatic liver disease, 19 patients (13 primary biliary cirrhosis, 4 sclerosing cholangitis and 2 chronic extrahepatic bile duct obstruction) underwent clinical and biochemical evaluations, liver biopsies and an aminopyrine breath test. Results were compared with those in 10 patients with biopsy‐proven chronic active hepatitis with bridging and/or cirrhosis and in 22 healthy subjects.

Carmen De Lemos‐Chiarandini, Fernando Alvarez, Olivier Bernard, Jean Claude Homberg, Gert Kreibich – 1 May 1987 – Human sera, containing anti‐liver‐kidney microsome antibody as demonstrated by indirect immunofluorescence, were obtained from a subgroup of young patients with autoimmune chronic hepatitis. The anti‐liver‐kidney microsome antibody‐positive sera were used to study the localization of the liver‐kidney microsome antigen in hepatocytes.

Sum P. Lee, Cliff Tasman‐Jones, Valerie F. Carlisle – 1 May 1987 – Rabbits fed a diet rich in oleic acid develop gallstones consisting of calcium salts of (5α)‐glyco‐allodeoxycholic acid. To study the metabolic pathway of oleic acid, we followed the changes in plasma, hepatic and biliary lip‐ids in this animal model. In addition, to also determine the role played by intestinal microflora on biliary lipid metabolism, we added kanamycin to the oleic acid diet. Oleic acid‐fed rabbits rapidly developed hypercholes‐terolemia.