Human hepatocellular carcinoma: Cross‐reactive and idiotypic antigens associated with malignant transformation of epithelial cells

Karl H. Wiedmann, Ludwik K. Trejdosiewicz, Jennifer Southgate, Howard C. Thomas – 1 May 1987 – Monoclonal antibodies were isolated following immunization with the HBsAg and α‐fetoprotein‐secreting human hepatoma PLC/PRF/5 (“Alexander”) cell line. Three antibodies (K‐PLC1, K‐PLC2 and K‐PLC3) showed evidence of carcinoma‐associated reactivity by indirect immunofluorescence. Antibodies K‐PLC2 and K‐PLC3 reacted only with PLC/PRF/5 cells, but not with any other normal or malignant cell type tested, including the Hep/G2 hepatoma cell line.

Effect of complete sulfation of bile acids on bile formation in rats

Ibrahim M. Yousef, Stephen G. Barnwell, Beatriz Tuchweber, Andrée Weber, Claude C. Roy – 1 May 1987 – The effect of sulfation of common bile acids on the formation of bile was investigated in male rats by infusing them with the sulfate esters of cholic, chenodeoxycholic, deoxycholic, lithocholic or dehydrocholic acid in four step‐wise, increasing doses. Each dose was infused for 30 min and bile collected every 10 min.

Propranolol for prevention of recurrent gastrointestinal bleeding in patients with cirrhosis: A prospective study of factors associated with rebleeding

Thierry Poynard, Didier Lebrec, Patrick Hillon, Raymond Sayegh, Jacques Bernuau, Sylvie Naveau, Jean‐Claude Chaput, Claude Klepping, Bernard Rueff, Jean‐Pierre Benhamou – 1 May 1987 – In a previous randomized trial, we demonstrated that propranolol prevented recurrent gastrointestinal bleeding in patients with cirrhosis. We have undertaken the present study in a new group of patients to ascertain the factors associated with rebleeding. Among 232 patients with cirrhosis admitted for gastrointestinal bleeding, 127 were included.

Effects of therapeutic paracentesis on systemic and hepatic hemodynamics and on renal and hormonal function

Douglas M. Simon, J. Ross McCain, Herbert L. Bonkovsky, James O. Wells, Diane K. Hartle, John T. Galambos – 1 May 1987 – Thirteen patients with cirrhosis and tense ascites (six with and seven without peripheral edema) underwent 4‐ to 15‐liter paracentesis without intravenous “colloid” replacement. Cardiac output increased from 6.6 ± 0.7 liters per min at baseline to 8.2 ± 0.7 liters per min (p < 0.003) 1 hr after large‐volume paracentesis completion and fell to 7.5 ± 0.69 liters per min (p < 0.05 vs. baseline, p < 0.02 vs. 1 hr) 24 hr after large‐volume paracentesis completion.

Interferon‐γ production by peripheral blood mononuclear cells of patients with chronic liver disease

Akihiko Fuji, Shinichi Kakumu, Yoshiyuki Ohtani, Kenichi Murase, Hideo Hirofuji, Hirofumi Tahara – 1 May 1987 – We investigated the role of the interferon system in the pathogenesis of chronic liver disease. Interferon‐γ production by peripheral blood mononuclear cells was measured with an ELISA.

The evolution of changes in quantitative liver function tests in a rat model of biliary cirrhosis: Correlation with morphometric measurement of hepatocyte mass

John B. Gross, Juerg Reichen, Thomas B. Zeltner, Arthur Zimmermann – 1 May 1987 – The aim of this study was to determine the prognostic significance of functional changes in the liver during progression of cirrhosis. Liver function was quantitated weekly by the aminopyrine breath test (measuring microsomal function) and the galactose breath test (measuring cytosolic function) in rats made cirrhotic by bile duct ligation (n = 14) and in sham‐surgery controls (n = 9). Nine rats died spontaneously of cirrhosis.

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