David L. Williams, Edward R. Sherwood, Rose B. McNamee, Ernest L. Jones, I. William Browder, Nicholas R. di Luzio – 1 November 1987 – Previous studies from our laboratory have demonstrated that particulate glucan is efficacious in the therapy of a syngeneic murine reticulum cell sarcoma (M5706), which specifically metastasizes from its primary site to the liver. The present study was undertaken to examine the therapeutic efficacy of a newly developed soluble glucan, in combination with cyclophosphamide in the treatment of hepatic metastatic disease.

Erik Christensen – 1 November 1987

Kay Tanaka – 1 November 1987 – Treatment of rats with hypoglycaemic doses of hypoglycin has been shown to abolish the relative detritiation of [2‐3H, U‐14C]glucose [Osmundsen, Billington, Taylor & Sherratt (1978) Biochem. J. 170, 337–342], indicating that both the Cori and the glucose/glucose 6‐phosphate cycles were inhibited in vivo. This inhibition was confirmed and, in addition, it was shown that the conversion in vivo of both [14C]lactate and [14C]fructose into glucose was decreased after hypoglycin treatment.

HYMANJ. ZIMMERMAN – 1 November 1987 – The hepatotoxic effect of venom sac extract (VSE) of the Oriental hornet has already been demonstrated using the well‐known models of experimental toxicology: in vivo, isolated in situ and in vitro. The present work deals with a series of 48 rats treated daily with 5 mg VSE/kg body weight for 1–14 days. Serum activities of alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), and γ‐glutamyl transferase (GGT) were measured. Liver tissue fractionation was performed.

Joan A. Keiser, Juan C. Romero, Louis J. Kost, Nicholas F. Larusso – 1 November 1987 – Since the liver is thought to be the major organ for the metabolism of renin, the rate‐limiting enzyme in the renin‐angiotensin cascade, we examined the kinetics and regulation of renin extraction by the isolated perfused rat liver. Partially purified, hog kidney renin was continuously infused into isolated rat livers perfused in a nonrecirculating manner with serum‐free medium.

1 November 1987

1 November 1987

Jennifer L. Cruise, Stuart J. Knechtle, R. Randal Bollinger, Cynthia Kuhn, George Michalopoulos – 1 November 1987 – The effects of several treatments involving α‐adrenergic mechanisms upon the early stages of rat liver regeneration were examined. Catecholamine concentrations in rat plasma were measured at various times after hepatectomy and were found to be elevated relative to those in plasma from sham‐operated rats.

Premila Trivedi, Juha Risteli, Leila Risteli, M. Stuart Tanner, Sheila Bhave, Anand N. Pandit, Alex P. Mowat – 1 November 1987 – While serum concentrations of antigens of the aminopropeptide of type III procollagen have been considered as indicators of hepatic pathology in adults, the high concentrations normally found in children during growth may preclude their use in pediatric liver disease.

Hans P. Dienes, Thomas Hütteroth, Georg Hess, Stefan C. Meuer – 1 November 1987 – The present knowledge of the inflammatory reaction occurring in situ during hepatitis B favors a T cell‐dependent MHC‐restricted immune response. However, the reports in the literature are primarily based on the application of monoclonal antibodies directed at different lymphocyte subsets which discern only lymphocytic phenotypes and do not reflect the actual situation adequately.