Moreye Nusbaum – 1 July 1987

Mary E. Charlson – 1 July 1987 – It has been suggested that gallbladder removal may protect against subsequent development of myocardial infarction because of increased gastrointestinal cholesterol excretion resulting from increased enterohepatic cycling. To test this hypothesis, the authors used data from two large case‐control studies of myocardial infarction–‐one conducted in 1976–1979 in 155 US hospitals and one conducted in 1980–1983 in 78 US hospitals. First, 550 female myocardial infarction cases were compared to 1,658 controls.

Xiening Wu – 1 July 1987 – Gallstones, which were diagnosed in 365 patients on the basis of symptoms, signs, ultrasound scanning and cholecystography were treated by compression of specific auricular points. The patients were predominantly women (76%) from 19 to 78 years of age. The stones were in the gallbladder in 326, in intrahepatic ducts in 20, in the common bile duct in 6 and at multiple sites in 14.

Sugantha Govindarajan, Cynthia C. Nast, William L. Smith, Martin A. Koyle, George Daskalopoulos, Robert D. Zipser – 1 July 1987 – To evaluate possible causes of the diminished prostaglandin production in advanced hepatorenal syndrome, prostaglandin endoperoxide synthase and prostacyclin synthase were localized and semiquantitated by immunofluorescence in postmortem, biopsy and nephrectomy renal tissues. In normal kidneys, antiprostacyclin synthase serum caused intense staining in peritubular capillaries, in the adjacent renal interstitial cells and in glomerular mesangial regions.

Richard B. Jennett, Dean J. Tuma, Michael F. Sorrell – 1 July 1987 – Immunization of mice with acetaldehyde conjugated to human plasma proteins resulted in the production of polyclonal antibodies that reacted with erythrocyte protein‐acetaldehyde conjugates, but not with control erythrocyte proteins. Such antibodies recognized erythrocyte protein‐acetaldehyde conjugates prepared with 20–100 μM acetaldehyde, concentrations that exist in the blood of alcoholics. The antibodies also recognized acetaldehyde condensation products with synthetic poly‐(L‐lysine).

Joseph M. Guattery, William W. Faloon – 1 July 1987 – The repeated observation of a fall in serum enzymes at midmenstrual cycle in an untreated patient with primary biliary cirrhosis stimulated a study of estrogen administration in five patients with primary biliary cirrhosis. One patient was premenopausal, one patient was postmenopausal and three had had oophorectomy. After 2 weeks of ethinyl estradiol, AST was under 100 IU per dl in all and had decreased by 50% or more in 4 of 5 patients.

GÜL Bakti, Hans U. Fisch, Georg Karlaganis, Christoph Minder, Johannes Bircher – 1 July 1987 – Mechanisms responsible for disproportional sedation resulting from triazolam administration to patients with cirrhosis were investigated. Ordinary sedative doses (0.25 mg) were given p.o. to 8 cirrhotics and 18 controls. Plasma concentrations of unbound drug were assessed by capillary gas chromatography and equilibrium dialysis. Median apparent oral clearances of unbound triazolam were 14.8 ml per min per kg in cirrhotics and 23.9 ml per min per kg in controls (p < 0.01).

Lawrie W. Powell – 1 July 1987 – Electron microscopic studies of acidophilic or Councilman‐like bodies in the liver show that they are manifestations of apoptosis. The morphology and biochemistry of apoptosis suggest a process of active cellular self‐destruction rather than degeneration. The incidence of apoptosis indicates that it is normally involved in the regulation of organ size and, in addition, may be triggered by specific pathological stimuli. Cell death produced in vitro by various types of cell‐mediated immune injury occurs by apoptosis

Jay H. Hoofnagle, David A. Shafritz, Hans Popper – 1 July 1987

Patricia L. Marion, John M. Cullen, Roberto R. Azcárraga, Mary Jo Van Davelaar, William S. Robinson – 1 July 1987 – We investigated experimental transmission of duck hepatitis B virus to its original host, the domestic Pekin duck, and to three other avian species.