Charles F. Gholson, Michael R. Freeman, Ricardo Mastai, Jaime Bosch, Robin D. Hughes, Roger Williams, David G. Parsons – 1 July 1987

1 July 1987

Danielle P. Praaning‐Van Dalen, A. Margreet De Leeuw, A. Brouwer, Dick L. Knook – 1 July 1987 – The capacity of rat liver Kupffer and endothelial cells to endocytose glycoproteins with N‐acetylglucosamine‐or mannose‐terminated oligosaccharide chains was studied. For this purpose, agalactoorosomucoid, ahexo‐saminoorosomucoid and horseradish peroxidase were used as ligands. A reliable determination of the amount of ligand endocytosed in vivo or in vitro was made possible by using the recently developed cold pronase method for the isolation and purification of Kupffer and endothelial cells.

Patricia L. Marion, John M. Cullen, Roberto R. Azcárraga, Mary Jo Van Davelaar, William S. Robinson – 1 July 1987 – We investigated experimental transmission of duck hepatitis B virus to its original host, the domestic Pekin duck, and to three other avian species.

Jay H. Hoofnagle, David A. Shafritz, Hans Popper – 1 July 1987

Lawrie W. Powell – 1 July 1987 – Electron microscopic studies of acidophilic or Councilman‐like bodies in the liver show that they are manifestations of apoptosis. The morphology and biochemistry of apoptosis suggest a process of active cellular self‐destruction rather than degeneration. The incidence of apoptosis indicates that it is normally involved in the regulation of organ size and, in addition, may be triggered by specific pathological stimuli. Cell death produced in vitro by various types of cell‐mediated immune injury occurs by apoptosis

GÜL Bakti, Hans U. Fisch, Georg Karlaganis, Christoph Minder, Johannes Bircher – 1 July 1987 – Mechanisms responsible for disproportional sedation resulting from triazolam administration to patients with cirrhosis were investigated. Ordinary sedative doses (0.25 mg) were given p.o. to 8 cirrhotics and 18 controls. Plasma concentrations of unbound drug were assessed by capillary gas chromatography and equilibrium dialysis. Median apparent oral clearances of unbound triazolam were 14.8 ml per min per kg in cirrhotics and 23.9 ml per min per kg in controls (p < 0.01).

Joseph M. Guattery, William W. Faloon – 1 July 1987 – The repeated observation of a fall in serum enzymes at midmenstrual cycle in an untreated patient with primary biliary cirrhosis stimulated a study of estrogen administration in five patients with primary biliary cirrhosis. One patient was premenopausal, one patient was postmenopausal and three had had oophorectomy. After 2 weeks of ethinyl estradiol, AST was under 100 IU per dl in all and had decreased by 50% or more in 4 of 5 patients.

Richard B. Jennett, Dean J. Tuma, Michael F. Sorrell – 1 July 1987 – Immunization of mice with acetaldehyde conjugated to human plasma proteins resulted in the production of polyclonal antibodies that reacted with erythrocyte protein‐acetaldehyde conjugates, but not with control erythrocyte proteins. Such antibodies recognized erythrocyte protein‐acetaldehyde conjugates prepared with 20–100 μM acetaldehyde, concentrations that exist in the blood of alcoholics. The antibodies also recognized acetaldehyde condensation products with synthetic poly‐(L‐lysine).

Sugantha Govindarajan, Cynthia C. Nast, William L. Smith, Martin A. Koyle, George Daskalopoulos, Robert D. Zipser – 1 July 1987 – To evaluate possible causes of the diminished prostaglandin production in advanced hepatorenal syndrome, prostaglandin endoperoxide synthase and prostacyclin synthase were localized and semiquantitated by immunofluorescence in postmortem, biopsy and nephrectomy renal tissues. In normal kidneys, antiprostacyclin synthase serum caused intense staining in peritubular capillaries, in the adjacent renal interstitial cells and in glomerular mesangial regions.