Evidence that host size determines liver size: Studies in dogs receiving orthotopic liver transplants

Igal Kam, Steven Lynch, Gregory Svanas, Satori Todo, Lorenzo Polimeno, Antonio Francavilla, Ronald J. Penkrot, Sunichi Takaya, Bo G. Ericzon, Thomas E. Starzl, David H. Van Thiel – 1 March 1987 – Orthotopic liver transplantation was performed in two groups of dogs; Group I animals consisted of large dogs that served as recipients of livers obtained from smaller dogs while Group II animals consisted of dogs that received liver from donor dogs of nearly the same size.

Focal Infiltrations of Polymorphonuclear Leukocytes in Liver Biopsies: Traumatic Lesions?

L. Frederick Fenster, Harold O. Conn – 1 March 1987 – A young man with chronic active hepatitis was heavily sedated during an attempted transjugular liver biopsy. The procedure was abandoned after 3 h and an immediate percutaneous liver biopsy was performed. This showed features of chronic active hepatitis but, in addition, groups of poly‐morphonuclear leukocytes in the parenchyma. These were similar to the operation associated neutrophils encountered in liver biopsies taken during the course of abdominal surgery.

Dating gallstones

David F. Ransohoff – 1 March 1987 – We investigated the natural history of cholelithiasis in 59 samples of stones from the gallbladder or common bile duct in 15 patients, using as a tracer for the timing of stone formation the 14C released into the environment during nuclear weapons testing. The ages of the stones were correlated with the dates of onset of symptoms and with other clinical data.

Portacaval shunt and the reacquisition of γ‐glutamyl transpeptidase activity

J. P. Colombo – 1 March 1987 – Portacaval shunt (PCS) operations were performed on male inbred SD rats. The activity of liver γ‐glutamyltranspeptidase (GGT) increased a few days after the operation and remained high after several months. However, the activity was only present in periportal areas of liver lobules and was mainly restricted to the endothelial lining cells of periportal blood vessels. Phenobarbital sodium (CAS: 57–03–7) administration did not change the distribution of GGT.

Comparative effects of deoxycholate and 7‐methyl‐deoxycholate in the hamster

Syoji Kuroki, Erwin H. Mosbach, Richard J. Stenger, Bertram I. Cohen, Charles K. McSherry – 1 March 1987 – The metabolism and effect on biliary lipids of a new bile acid analog, 7‐methyl‐deoxycholic acid, were studied and compared with those of deoxycholic acid in the hamster. 14C‐Labeled 7‐methyl‐deoxycholic acid and deoxycholic acid were administered intravenously or intraduodenally to bile fistula hamsters at 1.0 or 4.0 μmoles per min·kg, and hepatic bile was analyzed for radioactive metabolites and biliary lipid outputs.

Bile salts induce calcium uptake in vitro by human erythrocytes

David G. Oelberg, William P. Dubinsky, Jeffrey W. Sackman, Leslie B. Wang, Eugene W. Adcock, Roger Lester – 1 March 1987 – At high concentrations, bile salts induce hemolysis by comicellization of lipid components of the cell membrane. However, bile salts are also associated with hemolysis at lower concentrations by mechanisms which have not been characterized.

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