John H. Helzberg, Mark S. Brown, Daniel J. Smith, John C. Gore, Ellen R. Gordon – 1 January 1987 – In vivo31phosphorus nuclear magnetic resonance spectroscopy was used to measure the hepatic metabolic state in various groups of rats given ethanol, a control liquid diet or a solid chow diet. The use of selective presaturation pulses applied to the broad phosphorus resonances of immobile phospholipids permitted reliable determination of ATP/ADP ratios by quantitation of the ATP‐β and ATP‐γ peak areas.

Thomas Horn, Per Christoffersen, Jens H. Henriksen – 1 January 1987 – The fenestration of hepatic sinusoidal endothelial cells in 15 needle biopsies obtained from chronic alcoholics without cirrhosis was studied by scanning electron microscopy. As compared to nonalcoholics, a significant reduction in the number of fenestrae and porosity of the sinusoidal lining wall (fractional area of fenestrae) was observed in acinar Zone 3, both in biopsies with and without Zone 3 fibrosis as judged by light microscopy.

Jaime Kapitulnik, Evelyn Weil, Ron Rabinowitz, Michael M. Krausz – 1 January 1987 – The fluidity and lipid composition of the human hepatic microsomal membrane were studied in 11 livers from 16‐ to 21‐week‐old fetuses and in 5 adult livers, and compared with those of fetal and adult rat liver microsomes. Membrane fluidity was analyzed by measurement of fluorescence polarization using the fluorophore 1,6‐diphenyl‐1,3,5‐hexatriene.

1 January 1987

Anthony J. Stellon, Adrian Webb, Juliet Compston, Roger Williams – 1 January 1987 – To determine whether bone loss in patients with chronic cholestatic liver disease is the consequence of a high or low bone turnover state, 30 female patients with biopsy‐proven primary biliary cirrhosis underwent iliac crest biopsy following double tetracycline labeling. The mean trabecular bone volume was decreased as a result of trabecular plate thinning in both the premenopausal (p < 0.02) and postmenopausal (p < 0.05) patients, compared to age‐ and sex‐matched controls.

Jean‐Pierre Villeneuve, P.‐Michel Huet – 1 January 1987

Richard Moreau, Samuel S. Lee, Antoine Hadengue, Alain Braillon, Didier Lebrec – 1 January 1987 – A decrease in plasma noradrenaline—a reflection of sympathetic nervous system activity—by clonidine, a centrally acting α2‐agonist, could reduce the hyperdynamic circulation observed in cirrhosis and may thereby decrease portal hypertension. Plasma noradrenaline concentration and plasma renin activity as well as systemic and splanchnic hemodynamics were measured in 12 patients with cirrhosis and ascites before and after administration of either 150 μg of clonidine or placebo.

Albert Van De Wiel, Dominique L. Delacroix, Jan Van Hattum, Henk‐Jan Schuurman, Louis Kater – 1 January 1987 – Patients with alcoholic liver disease frequently reveal an increase in IgA serum concentration and IgA deposits in a continuous pattern along hepatic sinusoids. We investigated whether the hepatic IgA deposits are a passive reflection of changes in concentration or composition of IgA in the circulation, or represent a distinct effect of alcohol on the liver.

Frederick J. Carmichael, Victor Saldivia, Yedy Israel, John P. McKaigney, Hector Orrego – 1 January 1987 – While a number of studies show that acute oral administration of ethanol results in increases in liver blood flow, a large body of evidence has also been presented in which such an effect is not observed. To shed light on this discrepancy, we have studied in rats, a number of variables that might modulate or inhibit the effect of ethanol.

Arthur J. McCullough, William N. Stassen, Russell H. Wiesner, Albert J. Czaja – 1 January 1987 – To analyze the correlations between the presence of cirrhosis and hepatocellular inflammation and the serum concentrations of the amino‐terminal peptide of procollagen type III in chronic liver disease, we measured procollagen type III concentrations in paired serum samples from 46 patients (17 had cirrhosis) with severe chronic active hepatitis during a therapeutic treatment trial.