1 January 1987

Yun‐Fan Liaw, Dar‐In Tai, Chia‐Ming Chu, Chia C. Pao, Tong‐Jong Chen – 1 January 1987 – The incidence, clinicopathological features and etiology of acute exacerbation occurring in patients with chronic type B hepatitis were assessed prospectively among 385 patients who had HBeAg and 279 who had anti‐HBe in serum. During an average follow‐up of 23.5 months, acute exacerbations occurred in 197 HBeAg‐positive patients and in 56 anti‐HBe positive patients, with a calculated annual incidence of 28.6 and 10.3%, respectively (p < 0.001).

Atsushi Kanno, Hitoshi Ohori, Keizaburoh Matsuda, Haruo Nakayama, Yutaka Miyazaki, Motoyasu Ishii, Hiroshi Suzuki, Masao Ohtsuki, Yoshio Goto – 1 January 1987 – In order to establish the virological significance of HBeAg subtypes (HBeAg/1 and HBeAg/2) during hepatitis B virus infection, HBsAg, HBeAg and hepatitis B virus DNA in serum and HBeAg in liver were determined quantitatively in relation to the detection of HBeAg subtypes in agar gel diffusion.

Jan Van Hattum, Geziena M. Th. Schreuder, Solko W. Schalm – 1 January 1987 – The course after hepatitis B virus infection seems to be determined by the host's immune response, which in turn may be regulated by the major histocompatibility complex. In order to find a possible relationship between the course of disease and the phenotype frequency of HLA determinants, we studied 396 Dutch subjects of northern European local race. Six groups of individuals with various courses after hepatitis B virus infection were compared to healthy controls.

Paul D. Berk, Barry J. Potter, Wolfgang Stremmel – 1 January 1987

James E. Heubi, John C. Partin, Jacqueline S. Partin, William K. Schubert – 1 January 1987

Laurence M. Blendis, Michael J. Sole, Peter Campbell, Alan G. Lossing, Paul D. Greig, Bryce R. Taylor, Bernard Langer – 1 January 1987 – The elevated catecholamine levels in cirrhotic patients with ascites have been proposed to be due to sympathetic overactivity secondary either to reduced intravascular volume or to an underlying cardiovascular abnormality such as reduced pressor responsiveness. Furthermore, these elevated catecholamine levels have been proposed to be involved in the pathogenesis of salt and water retention.

Tzee Chung Wu, Myron J. Tong, Betau Hwang, Shou‐Dong Lee, Mu Mei Hu – 1 January 1987 – Twenty pediatric patients with primary hepatocellular carcinoma in Taiwan were tested for HBsAg, and all were found to be positive. The youngest case was 8 months of age, five cases occurred between 9 and 10 years of age, and 14 cases occurred between 11 and 16 years of age. The serum α‐fetoprotein was elevated in all 20 primary hepatocellular carcinoma patients, and the average survival of these cases after diagnosis was 4.7 months.

Toshikazu Uchida, Koyu Suzuki, Mariko Esumi, Masayuki Arii, Masashi Oomura, Toshio Shikata – 1 January 1987 – A sequential study was performed to investigate the occurrence and localization of duck hepatitis B virus in the liver of domestic ducks utilizing the indirect immunoperoxidase method and electron microscopy. Seventeen ducklings were injected intravenously with duck hepatitis B virus‐positive serum within 24 hr after hatching and were subsequently sacrificed on the 2nd, 3rd, 4th, 5th, 27th and 44th day after injection.

Yohko K. Shimizu, Robert H. Purcell, John L. Gerin, Stephen M. Feinstone, Yasushi Ono, Toshio Shikata – 1 November 1986 – To further investigate the specificity of the monoclonal antibodies (48‐1 and S‐1) associated with non‐A, non‐B hepatitis, extensive immunofluorescence studies were performed on liver biopsy specimens from chimpanzees with experimental hepatitis A, B, non‐A, non‐B or δ, or from normal chimpanzees.