Nicola Tavoloni, Herman R. Wyssbrod, Mary Jane T. Jones – 1 November 1986 – To determine the mechanism and pathway of entry of polar nonelectrolytes into bile, we studied first the permeation of [3H]H2O, [14C]urea, [14C]erythritol, [14C]mannitol, [3H]sucrose, [3H]inulin and [3H]dextran across an isolated, in situ perfused segment of the guinea pig's extrahepatic bile duct. All of these molecules, except [3H]dextran, permeated the bile duct. The diffusive permeability coefficients (cm per sec per 106) ranged from 248 for [3H]H2O to 1.2 for [3H]inulin.

Andrew K. Burroughs, Francois d'Heygere, Neil McIntyre – 1 November 1986

Takashi Moriyama, Hiromu Aoyama, Shin Ohnishi, Michio Imawari – 1 November 1986 – The effects of supplementation with fibronectin on liver damage and survival in rats with galactosamine‐induced liver failure were studied.

Louis M. Havekes, Hans Verboom, Elly de Wit, Sing Hiem Yap, Hans M. G. Princen – 1 November 1986 – The low density lipoprotein receptor activity was measured in primary cultures of human hepatocytes. The receptor‐mediated association and degradation of low density lipoprotein increased gradually up to 140 and 190%, respectively, upon incubation of the cells with increasing amounts of whole serum (up to 100%).

Robert P. Perrillo, Fredric G. Regenstein – 1 November 1986

Karen L. Lindsay, J. Anne Nizze, Ronald Koretz, Gary Gitnick – 1 November 1986 – Numerous tests to detect anti‐HBc IgM have been developed and shown to have different degrees of sensitivity and specificity. One of these assays, Corzyme®‐M (Abbott Laboratories, North Chicago, Ill.), recently became commercially available. The present study was undertaken to evaluate the clinical utility of this anti‐HBc IgM test in establishing the diagnosis of acute hepatitis B using sera from a group of 42 prospectively followed individuals who had been exposed to hepatitis B virus.

Alan F. Hofmann, Nicholas F. Larusso – 1 November 1986

Michael A. Gerber, Pedro J. Grases – 1 November 1986 – A new type of ground‐glass hepatocyte is described. The appearance is due to pale, homogeneous, weakly eosinophilic inclusions filling a portion of or the entire hepatocytic cytoplasm. On haematoxylin and eosin stained sections, these cells closely resemble ground‐glass hepatocytes described in other conditions. However, they are negative on special stains for HBsAg and on PAS staining. Immunohistochemically, they reveal a selective and exclusive positivity for fibrinogen.

A. K. Burroughs – 1 November 1986 – Between October, 1981 and December 1983, 46 consecutive unselected cirrhotic patients who had been admitted for variceal hemorrhage were assigned to propranolol for the prevention of variceal rebleeding and followed for a mean period of 13.3 months (ranges: 1 day, 45 months). At the time of inclusion, 87 p. 100 of patients had alcoholic cirrhosis: ascites was present in 43 p. 100, jaundice in 43 p. 100 and encephalopathy in 33 p. 100 of cases.

B. A. Runyon, D. Jüngst, A. L. Gerbes, G. Paumgartner – 1 November 1986