Sarah Jane Schwarzenberg, Harvey L. Sharp, Robin D. Manthei, Steven Seelig – 1 November 1986 – We quantitated α1‐antitrypsin mRNA in normal, α1‐antitrypsin‐deficient cirrhotic and biliary cirrhotic livers using two‐dimensional electrophoretograms of [35S] methionine‐labeled translational products of total hepatic RNA and RNA/DNA hybridization. α1‐antitrypsin precursor product was identified by immunoprecipitation.

Andres T. Blei – 1 November 1986 – The effects of a somatostatin analogue, SMS 201‐995 on hepatic haemodynamics were studied in rats with dimethylnitrosamine‐induced cirrhosis. An intravenous infusion of 1, 2 or 4 μg kg−1 body wt h−1 SMS 201‐995 produced a rapid and sustained decrease in portal pressure, portal venous flow and liver blood flow without significantly altering arterial blood pressure or pulse. The reductions in portal pressure, portal venous flow and liver blood were accompanied by an increase in splanchnic vascular resistance. Portal venous resistance was not affected.

Denis J. Miller – 1 November 1986

G. S. Tint – 1 November 1986

1 November 1986

Ronald J. Sokol, James E. Heubi, Catherine McGraw, William F. Balistreri – 1 November 1986 – Although secondary vitamin E deficiency causes a reversible neurologic disorder in children with chronic cholestasis, the effect of this deficiency state on other organ systems is unknown. We studied the effects of vitamin E therapy on selected gastrointestinal and hepatic functions in five children with chronic cholestasis and well‐documented biochemical and neurologic evidence of vitamin E deficiency.

Bernardo Buitrago, Stephen C. Hadler, Hans Popper, Swan N. Thung, Michael A. Gerber, Robert H. Purcell, James E. Maynard – 1 November 1986 – “Santa Marta” hepatitis has been recognized as an unusual type of severe hepatitis occurring in northern Colombia since 1930. Liver specimens from a historic viscerotomy series, used by Gast‐Galvis to identify cases and describe epidemiologic features of this disease, were available for review and histopathologic staining for δ‐virus.

Giorgio Verme, Pietro Amoroso, Gennaro Lettieri, Paola Pierri, Ezio David, Fausto Sessa, Roberto Rizzi, Ferruccio Bonino, Serafino Recchia, Mario Rizzetto – 1 November 1986 – The histopathology of hepatitis delta virus disease was studied in carriers of HBsAg with chronic hepatitis delta antigen‐positive hepatitis and in serial biopsies of patients with acute hepatitis delta virus hepatitis that progressed to chronicity.

Angelika Vallbracht, Peter Gabriel, Katharina Maier, Franz Hartmann, Hans Jörg Steinhardt, Claudia Müller, Alexis Wolf, Klaus Herbert Manncke, Bertram Flehmig – 1 November 1986 – We studied cell‐mediated cytotoxicity to hepatitis A virus‐infected cells in seven patients with acute type A hepatitis and two controls. Skin fibroblast cultures obtained from the skin biopsies of seven patients after acute hepatitis A virus infection and from two persons without history of current or past hepatitis A virus infection were inoculated with hepatitis A virus.

Swan N. Thung, Michael A. Gerber, Efthimios J. Kasambalides, Bal K. Gilja, William Keh, Wolfram H. Gerlich – 1 November 1986 – The large (pre‐S1), middle (pre‐S2) and major (P24) polypeptides of HBsAg have been defined in detail, but their role in hepatitis B virus infection is not known. Therefore, we studied the expression of pre‐S1, pre‐S2 and P24 in the liver of 15 patients with acute or chronic hepatitis B virus infection using monoclonal and polyclonal antibodies in a double staining immunofluorescence method.