Membrane potential and hepatic uptake: Another rule of the game

Claudio Tiribelli – 1 September 1986 – Since glucagon can hyperpolarize hepatic plasma membrane and stimulate biliary bile acid secretion in vitro, we studied the effect of glucagon on taurocholate uptake and its relationship to plasma membrane potential in isolated rat hepatocytes. [14C]Taurocholate uptake was linear through 1 min and contained a saturable sodium‐dependent and a nonsaturable sodium‐independent component, Km of taurocholate uptake by the sodium‐dependent system was 18.4 μM.

Evidence for a deficiency of interferon production in patients with chronic hepatitis B virus infection acquired in adult life

Tadashi Ikeda, Andrew M. L. Lever, Howard C. Thomas – 1 September 1986 – Ninety per cent of patients infected in adult life with the hepatitis B virus clear the virus completely and 10% develop chronic infection. There is evidence for the involvement of interferon in the clearance of acute hepatitis B virus infection.

Nonsyndromatic paucity of interlobular bile ducts: Light and electron microscopic evaluation of sequential liver biopsies in early childhood

Ellen Kahn, Fredric Daum, James Markowitz, Saul Teichberg, Lynn Duffy, Rita Harper, Harvey Aiges – 1 September 1986 – Liver biopsies and/or autopsy specimens from 17 children (ages 1 week to 5 years) with nonsyndromatic paucity of the interlobular bile ducts were studied by light and electron microscopy. Initial biopsies were obtained before 90 days of age from all patients, and two or more specimens were available from nine. No specific underlying condition was found in nine infants.

The isolation of functionally heterogeneous hepatocytes of the proximal and distal half of the liver acinus in the rat

Jorge J. Gumucio, Maryann May, Caroline Dvorak, Jose Chianale, Veronica Massey – 1 September 1986 – The objective of this study was to isolate hepatocytes of the proximal half (Zones 1 and 2) or distal half (Zones 2 and 3) of the liver acinus.

Peripheral T‐cell lymphoma presenting as predominant liver disease: A report of three cases

Philippe Gaulard, Elie Serge Zafrani, Philippe Mavier, Francisco Dario Rocha, Jean‐Pierre Farcet, Marine Divine, Corinne Haioun, Yvon Pinaudeau – 1 September 1986 – Three cases of a peculiar form of peripheral T‐cell lymphoma presenting as predominant hepatic disease with splenomegaly are reported. The three patients had marked liver enlargement without lymphadenopathy; white blood cell count was normal, and modifications of hepatic tests were mild. In the three cases, the diagnosis of the lymphoma was mainly based on the results of hepatic morphological changes.

Receptor‐mediated uptake of asialoglycoprotein by the primate liver initiates both lysosomal and transcellular pathways

J. Michael Schiff, Sandra L. Huling, Albert L. Jones – 1 September 1986 – The degradation of asialoglycoproteins in hepatocytes has been well described in several animal models, but no direct evidence has yet been obtained for asialoglycoprotein processing in the primate liver. A double radiolabeling strategy was employed in the experiments described in this paper to evaluate the fate of asialoorosomucoid in the squirrel monkey. Intravenously injected asialoorosomucoid was taken up by the liver with a half‐time of 1 min.

Is shock‐wave lithotripsy the solution for gallstones in this, the year of the boom?

Leslie J. Schoenfield – 1 September 1986 – We treated nine patients with functioning gallbladders containing one to three symptomatic radiolucent stones not larger than 25 mm in diameter, as well as five patients with stones in the common bile duct that were not removable by endoscopic procedures, by means of extracorporeally generated shock waves during general anesthesia. The patients with gallbladder stones received adjuvant treatment with a combination of ursodeoxycholic acid and chenodeoxycholic acid.

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