Peripheral T‐cell lymphoma presenting as predominant liver disease: A report of three cases

Philippe Gaulard, Elie Serge Zafrani, Philippe Mavier, Francisco Dario Rocha, Jean‐Pierre Farcet, Marine Divine, Corinne Haioun, Yvon Pinaudeau – 1 September 1986 – Three cases of a peculiar form of peripheral T‐cell lymphoma presenting as predominant hepatic disease with splenomegaly are reported. The three patients had marked liver enlargement without lymphadenopathy; white blood cell count was normal, and modifications of hepatic tests were mild. In the three cases, the diagnosis of the lymphoma was mainly based on the results of hepatic morphological changes.

The isolation of functionally heterogeneous hepatocytes of the proximal and distal half of the liver acinus in the rat

Jorge J. Gumucio, Maryann May, Caroline Dvorak, Jose Chianale, Veronica Massey – 1 September 1986 – The objective of this study was to isolate hepatocytes of the proximal half (Zones 1 and 2) or distal half (Zones 2 and 3) of the liver acinus.

Nonsyndromatic paucity of interlobular bile ducts: Light and electron microscopic evaluation of sequential liver biopsies in early childhood

Ellen Kahn, Fredric Daum, James Markowitz, Saul Teichberg, Lynn Duffy, Rita Harper, Harvey Aiges – 1 September 1986 – Liver biopsies and/or autopsy specimens from 17 children (ages 1 week to 5 years) with nonsyndromatic paucity of the interlobular bile ducts were studied by light and electron microscopy. Initial biopsies were obtained before 90 days of age from all patients, and two or more specimens were available from nine. No specific underlying condition was found in nine infants.

Evidence for a deficiency of interferon production in patients with chronic hepatitis B virus infection acquired in adult life

Tadashi Ikeda, Andrew M. L. Lever, Howard C. Thomas – 1 September 1986 – Ninety per cent of patients infected in adult life with the hepatitis B virus clear the virus completely and 10% develop chronic infection. There is evidence for the involvement of interferon in the clearance of acute hepatitis B virus infection.

Membrane potential and hepatic uptake: Another rule of the game

Claudio Tiribelli – 1 September 1986 – Since glucagon can hyperpolarize hepatic plasma membrane and stimulate biliary bile acid secretion in vitro, we studied the effect of glucagon on taurocholate uptake and its relationship to plasma membrane potential in isolated rat hepatocytes. [14C]Taurocholate uptake was linear through 1 min and contained a saturable sodium‐dependent and a nonsaturable sodium‐independent component, Km of taurocholate uptake by the sodium‐dependent system was 18.4 μM.

Evaluation of aztreonam in the treatment of spontaneous bacterial peritonitis in patients with cirrhosis

Javier Ariza, Francisco Gudiol, Carlos Dolz, Javier Xiol, Josefina Liñares, Jorge Bosch, Roman Pallares – 1 September 1986 – To determine the efficacy of aztreonam in the treatment of spontaneous bacterial peritonitis in patients with hepatic cirrhosis, 14 patients (7 males, 7 females) with 16 Gram‐negative infective episodes (12 Escherichia coli and 4 Klebsiella pneumoniae) were treated with aztreonam infusions at doses of 1 gm per 8 hr for a planned 14‐day period. Ages ranged from 40 to 75 years with a mean of 57 ± 10 years.

Effect of 16,16‐dimethyl prostaglandin E2 on oxygen uptake and microcirculation in the perfused rat liver

Haruya Meren, France Varin, Mary Ruwart, Ronald G. Thurman – 1 September 1986 – Previous work demonstrated that collagen deposition in the liver of rats fed a nutritionally deficient diet for 3 to 4 months was diminished markedly by 16,16‐dimethyl prostaglandin E2 treatment. In this study, rats were fed a high‐fat diet or a high‐fat diet deficient in lipotropes for 2 to 4 weeks prior to liver perfusion. Rates of O2 uptake by the liver were not changed by dietary manipulation.

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