Heinrich Wernze, Wolfgang Tittor, Matthias Goerig – 1 September 1986 – Arterial and hepatovenous concentrations of circulating prostaglandin E2 and prostaglandin F2α, the stable metabolites of prostacyclin and thromboxane A2 were measured in patients with chronic liver disease and compared with those in control patients with coronary artery disease but without hepatic dysfunction. Specific radioimmunoassays were used after extraction on octadecyl C 18‐silica gel columns and thin‐layer chromatography.

Cyrus R. Kapadia – 1 September 1986

Josef Rosch – 1 September 1986 – A prospective study was undertaken to assess the results of embolization of esophageal varices by the transjugular approach, in 83 patients with advanced cirrhosis (65 p. 100 Child's class C) admitted with severe bleeding (mean of 10 units of blood per patient). Embolization was successfully completed in 65 patients (78 p. 100) and complete obliteration was achieved in 50 (60 p. 100). Twenty‐nine procedures were performed on actively bleeding patients. Cessation of bleeding was observed in 22 (76 p. 100).

R. J. Scothorne, R. N. M. Macsween – 1 September 1986 – Twenty male adult rats weighing 200 g were injected with tritiated thymidine (3HTdR). The animals were then killed in groups of five, at the following times: 1 h, 1, 3 and 5 weeks. Autoradi‐ograms of sections through the liver were prepared. The distances between labelled cells and the portal space rim were measured. One hour after labelling most labelled cells were confined to a region extending from the portal space rim up to a distance of 700 μm, which roughy corresponds to Rappaport's hepatic acinus zones‐1 and ‐2.

Willis C. Maddrey – 1 September 1986

Valentin Cuervas‐Mons, Isabel Millan, Judith S. Gavaler, Thomas E. Starzl, David H. van Thiel – 1 September 1986 – Twenty‐seven clinical and laboratory data and the subsequent clinical course of 93 consecutive adult patients who underwent orthotopic liver transplantation for various chronic advanced liver diseases were analyzed retrospectively to assess the risk factors of early major bacterial infection and death after the procedure. Forty‐one patients (44%) had early major bacterial infection during hospitalization for orthotopic liver transplantation.

Ronald L. Koretz – 1 September 1986

Mark I. Avigan, Gregory Adamson, Jay H. Hoofnagle, E. Anthony Jones – 1 September 1986 – Peripheral blood mononuclear cells from 7 patients with primary biliary cirrhosis and 7 healthy control subjects were studied for their ability to produce antibodies to mitochondrial antigens in vitro. Peripheral blood mononuclear cells were collected by lymphapheresis and cultured with or without pokeweed mitogen for 10 days. The culture supernatants were then tested for antibodies to mitochondrial antigens by both immunofluorescence microscopy and a microtiter ELISA.

David Rzepczynski, Leslie Zieve, Sandra Lindblad, Darlene Lafontaine – 1 September 1986 – The GABAergic agonist, muscimol, and antagonists, picrotoxin and bicuculline, have been studied in rats with chronic portacaval shunts and in rats developing hepatic encephalopathy after massive ischemic necrosis due to hepatic artery ligation within 48 hr of a portacaval shunt. After the chronic portacaval shunt and to a lesser extent in normal rats intraventricular muscimol resulted in chewing and eating behavior, ataxia and loss of balance that lasted 2 to 3 hr.

Charles S. Lieber, Anthony Garro, Maria A. Leo, Ki M. Mak, Theresa Worner – 1 September 1986