Jose Chianale, Caroline Dvorak, Maryann May, Jorge J. Gumucio – 1 September 1986 – Within the hepatic acinus, the functional unit of liver parenchyma, the induction of cytochrome P‐450 protein by phenobarbital is manifested primarily in hepatocytes located closer to the hepatic venule, i.e., distal hepatocytes.
Hidekazu Tsukamoto, Sally J. Towner, Lefran M. Clofalo, Samuel W. French – 1 September 1986 – Severe hepatic steatosis and focal necrosis of hepatocytes have previously been induced in rats by continuous intragastric infusion of ethanol and a diet containing only 5% fat as a per cent of total calories as reported by us previously.
Zsuzsa Schaff, Jay H. Hoofnagle, Philip M. Grimley – 1 September 1986 – Two types of cytomembranous abnormalities were identified for the first time in liver biopsies from patients with chronic active type B hepatitis during treatment with recombinant α‐interferon. Tubuloreticular inclusions were present in the hepatic endothelial cells, Kupffer cells and perisinusoidal cells of liver biopsies from both patients, and they were absent in liver biopsies obtained before treatment.
David Bullimore, J. P. Vinel, J. P. Pascal – 1 September 1986
Jean‐Jacques Lefrere, Danièle Gozin, Joelle Lerable, Jean‐Pierre Soulier – 1 September 1986
Deborah Trinder, Evan Morgan, Erica Baker – 1 September 1986 – The mechanisms of iron accumulation by cultured hepatocytes isolated from fetal rat liver (19 days gestation) were investigated using rat transferrin labeled with 125I and 59Fe. The rates of iron and transferrin internalization by the cells were measured by incubating the hepatocytes with the labeled transferrin at 37°C followed by treatment with pronase at 4°C to remove surface‐bound transferrin and iron. Iron internalization increased linearly with time.
Karen E. Shattuck, Anna Radominska‐Pyrek, Piotr Zimniak, Eugene W. Adcock, Roger Lester, Jan St. Pyrek – 1 September 1986 – 24‐Norlithocholic (3α‐hydroxy‐24‐nor‐5β‐cholan‐23‐oic) acid is the lower homologue of lithocholic acid, a potent cholestatic agent. In order to characterize its cholestatic potential and metabolic fate, 3β‐tritiated 24‐norlithocholate was infused intravenously into adult male Sprague‐Dawley rats prepared with an external biliary fistula.
Bertram I. Cohen, Erwin H. Mosbach, Charles K. McSherry, Richard J. Stenger, Syoji Kuroki, Beverly Rzigalinski – 1 September 1986 – The effects of a standard rodent chow were compared with those of a semisynthetic diet of known composition (with and without added cholesterol) in the prairie dog model of cholesterol cholelithiasis. Gallstone incidence was 40% higher in animals fed a semisynthetic diet plus cholesterol compared to chow plus cholesterol.
Joost J. van den Oord, Rita De Vos, Valeer J. Desmet – 1 September 1986 – Using a double‐staining immunohistochemical procedure, the topographical relationship between viral antigens on the one hand and the expression of major histocompatibility complex products by hepatocytes on the other hand was analyzed in a series of 19 liver biopsies from patients with chronic hepatitis B virus infection.