RORα Enhances Lysosomal Acidification and Autophagic Flux in the Hepatocytes

Hyeon‐Ji Kim, Yong‐Hyun Han, Ju‐Yeon Kim, Mi‐Ock Lee – 23 August 2021 – Lysosomes are intracellular acidic organelles with catabolic functions that contribute to the activation of autophagy. Although autophagy abnormality is associated with defects in lysosomal acidification during the progression of nonalcoholic fatty liver disease (NAFLD), the mechanisms of control of lysosomal acidification are not well understood at the molecular level.

Globo H Is a Promising Theranostic Marker for Intrahepatic Cholangiocarcinoma

Tsai‐Hsien Hung, Jung‐Tung Hung, Chiao‐En Wu, Yenlin Huang, Chien‐Wei Lee, Chau‐Ting Yeh, Yi‐Hsiu Chung, Fei‐Yun Lo, Li‐Chun Lai, John K. Tung, John Yu, Chun‐Nan Yeh, Alice L. Yu – 23 August 2021 – Recent studies support the development of cancer therapeutics to target Globo H‐ceramide, the most prevalent tumor‐associated carbohydrate antigen in epithelial cancers.

New‐Onset Antibodies to Platelet Factor 4 Following Liver Transplantation From a Donor With Vaccine‐Induced Thrombotic Thrombocytopenia

Mila Valsecchi, Andrea Lauterio, Roberto Crocchiolo, Riccardo De Carlis, Mariateresa Pugliano, Leonardo Centonze, Fabio Ferla, Matteo Zaniboni, Silvio Veronese, Gian Marco Podda, Luca Belli, Silvano Rossini, Luciano De Carlis, Roberto Fumagalli – 19 August 2021

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