Janine Dywicki, Laura Elisa Buitrago‐Molina, Fatih Noyan, Ana C. Davalos‐Misslitz, Katharina L. Hupa‐Breier, Maren Lieber, Martin Hapke, Jerome Schlue, Christine S. Falk, Solaiman Raha, Immo Prinz, Christian Koenecke, Michael P. Manns, Heiner Wedemeyer, Matthias Hardtke‐Wolenski, Elmar Jaeckel – 24 August 2021 – Nonalcoholic steatohepatitis (NASH) is induced by steatosis and metabolic inflammation. While involvement of the innate immune response has been shown, the role of the adaptive immune response in NASH remains controversial.

Mitchell R. McGill, Laura P. James, Sandra S. McCullough, Jeffery H. Moran, Samuel E. Mathews, Eric C. Peterson, Davis P. Fleming, Morgan E. Tripod, Joel H. Vazquez, Stefanie Kennon‐McGill, Horace J. Spencer, Jonathan A. Dranoff – 24 August 2021 – Current guidelines recommend restricting acetaminophen (APAP) use in patients with cirrhosis, but evidence to support that recommendation is lacking.

Rajalakshmi Govalan, Michael Luu, Marie Lauzon, Kambiz Kosari, Joseph C. Ahn, Nicole E Rich, Nicholas Nissen, Lewis R. Roberts, Amit G. Singal, Ju Dong Yang – 24 August 2021 – Prognosis of hepatocellular carcinoma (HCC) could be affected by lack of or delayed therapy. We aimed to characterize the prevalence, correlates, and clinical impact of therapeutic underuse and delay in patients with HCC. Patients with HCC diagnosed between 2010 and 2017 were analyzed from the United States National Cancer Database.

Keisuke Fukutomi, Hayato Hikita, Kazuhiro Murai, Tasuku Nakabori, Akiyoshi Shimoda, Makoto Fukuoka, Takuo Yamai, Yuichiro Higuchi, Kei Miyakawa, Hiroshi Suemizu, Akihide Ryo, Ryoko Yamada, Takahiro Kodama, Ryotaro Sakamori, Tomohide Tatsumi, Tetsuo Takehara – 24 August 2021 – Capsid allosteric modulators (CAMs) inhibit the encapsidation of hepatitis B virus (HBV) pregenomic RNA (pgRNA), which contains a pathogen‐associated molecular pattern motif.

Karis Kosar, Pamela Cornuet, Sucha Singh, Elizabeth Lee, Silvia Liu, Jenesis Gayden, Toshifumi Sato, Zachary Freyberg, Gavin Arteel, Kari Nejak‐Bowen – 24 August 2021 – We previously identified an up‐regulation of specific Wnt proteins in the cholangiocyte compartment during cholestatic liver injury and found that mice lacking Wnt secretion from hepatocytes and cholangiocytes showed fewer proliferating cholangiocytes and high mortality in response to a 3,5‐diethoxycarbonyl‐1,4‐dihydrocollidine (DDC) diet, a murine model of primary sclerosing cholangitis.

Nidhi Jalan‐Sakrikar, Thiago M. De Assuncao, Amaia Navarro‐Corcuera, Feda H. Hamdan, Lorena Loarca, Lindsey A. Kirkeby, Zachary T. Resch, Steven P. O’Hara, Brian D. Juran, Konstantinos N. Lazaridis, Charles B. Rosen, Julie K. Heimbach, Timucin Taner, Vijay H. Shah, Nicholas F. LaRusso, Robert C. Huebert – 24 August 2021 – Primary sclerosing cholangitis (PSC) is a chronic fibroinflammatory disease of the biliary tract characterized by cellular senescence and periportal fibrogenesis.

Norihiro Imai, Hayley T. Nicholls, Michele Alves‐Bezerra, Yingxia Li, Anna A. Ivanova, Eric A. Ortlund, David E. Cohen – 24 August 2021

Keith D. Lindor, Christopher L. Bowlus, James Boyer, Cynthia Levy, Marlyn Mayo – 23 August 2021

Christian L. Horn, Amilcar L. Morales., Christopher Savard, Geoffrey C Farrell, George N. Ioannou – 23 August 2021 – The rising prevalence of nonalcoholic fatty liver disease (NAFLD) and NAFLD‐related cirrhosis in the United States and globally highlights the need to better understand the mechanisms causing progression of hepatic steatosis to fibrosing steatohepatitis and cirrhosis in a small proportion of patients with NAFLD.

Kacey Berry, Andres Duarte‐Rojo, Joshua D. Grab, Michael A. Dunn, Brian J. Boyarsky, Elizabeth C. Verna, Matthew R. Kappus, Michael L. Volk, Mara McAdams‐DeMarco, Dorry L. Segev, Daniel R. Ganger, Daniela P. Ladner, Amy Shui, Monica A. Tincopa, Robert S. Rahimi, Jennifer C. Lai, from the Multi‐Center Functional Assessment in Liver Transplantation (FrAILT) Study – 23 August 2021 – Physical frailty and impaired cognition are common in patients with cirrhosis.