Adjunct Fenofibrate Up‐regulates Bile Acid Glucuronidation and Improves Treatment Response For Patients With Cholestasis

Gina M. Gallucci, Jocelyn Trottier, Christopher Hemme, David N. Assis, James L. Boyer, Olivier Barbier, Nisanne S. Ghonem – 26 August 2021 – Accumulation of cytotoxic bile acids (BAs) during cholestasis can result in liver failure. Glucuronidation, a phase II metabolism pathway responsible for BA detoxification, is regulated by peroxisome proliferator–activated receptor alpha (PPARα). This study investigates the efficacy of adjunct fenofibrate therapy to up‐regulate BA‐glucuronidation and reduce serum BA toxicity during cholestasis.

Early and accurate detection of cholangiocarcinoma in patients with primary sclerosing cholangitis by methylation markers in bile

Hege Marie Vedeld, Marit M. Grimsrud, Kim Andresen, Heidi D. Pharo, Erik Seth, Tom H. Karlsen, Hilde Honne, Vemund Paulsen, Martti A. Färkkilä, Annika Bergquist, Marine Jeanmougin, Lars Aabakken, Kirsten M. Boberg, Trine Folseraas, Guro E. Lind – 25 August 2021

Hepatology Highlights

Nabeel Wahid, Arun Jesudian, Adam Buckholz, Robert S. Brown, Danielle Kovac, Amani Lee, Enis Kostallari, Robert E. Schwartz, Petra Hirsova, Nidhi Jalan‐Sakrikar, Amneet Hans, Giorgio Roccaro, Alyson Kaplan, Hirsh Trivedi, Mina Choudhry, Daryl T.Y. Lau, Anthony J. Choi – 25 August 2021

A conventional immune regulator mitochondrial antiviral signaling protein blocks hepatic steatosis by maintaining mitochondrial homeostasis

Jiajun Fu, Fengjiao Hu, Tengfei Ma, Wen‐Jie Zhao, Han Tian, Yan Zhang, Manli Hu, Junjie Zhou, Yanfang Zhang, Chongshu Jian, Yan‐Xiao Ji, Xiao‐Jing Zhang, Jingwei Jiang, Zhi‐Gang She, Xu Cheng, Peng Zhang, Lan Bai, Juan Yang, Hongliang Li – 25 August 2021

Follistatin‐controlled activin‐HNF4α‐coagulation factor axis in liver progenitor cells determines outcome of acute liver failure

Tao Lin, Shanshan Wang, Stefan Munker, Kyounghwa Jung, Ricardo U. Macías‐Rodríguez, Astrid Ruiz‐Margáin, Robert Schierwagen, Hui Liu, Chen Shao, Chunlei Fan, Rilu Feng, Xiaodong Yuan, Sai Wang, Franziska Wandrer, Christoph Meyer, Ralf Wimmer, Roman Liebe, Jens Kroll, Long Zhang, Tobias Schiergens, Peter ten Dijke, Andreas Teufel, Alexander Marx, Peter R. Mertens, Hua Wang, Matthias P.A. Ebert, Heike Bantel, Enrico De Toni, Jonel Trebicka, Steven Dooley, Donghun Shin, Huiguo Ding, Hong‐Lei Weng – 25 August 2021

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