Morphometric Analysis of Mast Cells in Tumor Predicts Recurrence of Hepatocellular Carcinoma After Liver Transplantation

Nataliya Rohr‐Udilova, Kaoru Tsuchiya, Gerald Timelthaler, Martina Salzmann, Tobias Meischl, Katharina Wöran, Judith Stift, Merima Herac, Rolf Schulte‐Hermann, Markus Peck‐Radosavljevic, Wolfgang Sieghart, Robert Eferl, Erika Jensen‐Jarolim, Michael Trauner, Matthias Pinter – 26 August 2021 – Tumor‐infiltrating immune cells are relevant prognostic and immunotherapeutic targets in hepatocellular carcinoma (HCC). Mast cells play a key role in allergic response but may also be involved in anticancer immunity.

Light Chain Deposition Disease: An Unusual Cause of Portal Hypertension

Molly Delk Plummer, Fredric Regenstein – 26 August 2021 – Light chain deposition disease (LCDD) is a rare entity that is generally discovered in the setting of solid organ dysfunction. The monoclonal gammopathy leads to abnormal deposition of light chains in tissues, most often manifested by way of renal dysfunction. Other organ systems may also be affected, the liver being the second‐most common after the kidneys. Liver involvement rarely leads to clinically significant disease, with few case reports in the literature.

Extracellular vesicles derived from mesenchymal stem/stromal cells: The regenerative impact in liver diseases

Adriana Psaraki, Lydia Ntari, Christos Karakostas, Despoina Korrou‐Karava, Maria G. Roubelakis – 26 August 2021 – Liver dysfunctions are classified into acute and chronic diseases, which comprise a heterogeneous group of pathological features and a high mortality rate. Liver transplantation remains the gold‐standard therapy for most liver diseases, with concomitant limitations related to donor organ shortage and lifelong immunosuppressive therapy.

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