Direct AMPK Activation Corrects NASH in Rodents Through Metabolic Effects and Direct Action on Inflammation and Fibrogenesis

Pascale Gluais‐Dagorn, Marc Foretz, Gregory R. Steinberg, Battsetseg Batchuluun, Anna Zawistowska‐Deniziak, Joost M. Lambooij, Bruno Guigas, David Carling, Pierre‐Axel Monternier, David E. Moller, Sebastien Bolze, Sophie Hallakou‐Bozec – 6 September 2021 – No approved therapies are available for nonalcoholic steatohepatitis (NASH). Adenosine monophosphate–activated protein kinase (AMPK) is a central regulator of cell metabolism; its activation has been suggested as a therapeutic approach to NASH.

Alcohol‐Induced Liver Injury: Down‐regulation and Redistribution of Rab3D Results in Atypical Protein Trafficking

Carol A. Casey, Amanda J. Macke, Ryan R. Gough, Artem N. Pachikov, Mary E. Morris, Paul G. Thomes, Jacy L. Kubik, Melissa S. Holzapfel, Armen Petrosyan – 6 September 2021 – Previous work from our laboratories has identified multiple defects in endocytosis, protein trafficking, and secretion, along with altered Golgi function after alcohol administration.

Impact of the Kasai Procedure and the Length of Native Liver Survival Time on Outcomes of Liver Transplantation for Biliary Atresia

Liwei Liu, Lin Wei, Wei Qu, Ying Liu, Zhigui Zeng, Haiming Zhang, Min Li, Jimin Liu, Hanlin L. Wang, Kexin Li, Yafei He, Jidong Jia, Liying Sun, Xinyan Zhao, Zhijun Zhu – 4 September 2021 – The aim is to explore the impact of the Kasai procedure (KP) and the length of native liver survival time (NLST) on outcomes of liver transplantation (LT). Patients with biliary atresia (BA), who underwent LT in Beijing Friendship Hospital from January 2017 to December 2019, were enrolled and divided into non‐KP (N‐KP) and post‐KP (P‐KP) groups.

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