Ductular reaction promotes intrahepatic angiogenesis through Slit2–Roundabout 1 signaling

Mar Coll, Silvia Ariño, Celia Martínez‐Sánchez, Ester Garcia‐Pras, Javier Gallego, Anna Moles, Beatriz Aguilar‐Bravo, Delia Blaya, Julia Vallverdú, Teresa Rubio‐Tomás, Juan Jose Lozano, Elisa Pose, Isabel Graupera, Andrea Fernández‐Vidal, Albert Pol, Ramón Bataller, Jian‐Guo Geng, Pere Ginès, Mercedes Fernandez, Pau Sancho‐Bru – 6 September 2021

Direct AMPK Activation Corrects NASH in Rodents Through Metabolic Effects and Direct Action on Inflammation and Fibrogenesis

Pascale Gluais‐Dagorn, Marc Foretz, Gregory R. Steinberg, Battsetseg Batchuluun, Anna Zawistowska‐Deniziak, Joost M. Lambooij, Bruno Guigas, David Carling, Pierre‐Axel Monternier, David E. Moller, Sebastien Bolze, Sophie Hallakou‐Bozec – 6 September 2021 – No approved therapies are available for nonalcoholic steatohepatitis (NASH). Adenosine monophosphate–activated protein kinase (AMPK) is a central regulator of cell metabolism; its activation has been suggested as a therapeutic approach to NASH.

Alcohol‐Induced Liver Injury: Down‐regulation and Redistribution of Rab3D Results in Atypical Protein Trafficking

Carol A. Casey, Amanda J. Macke, Ryan R. Gough, Artem N. Pachikov, Mary E. Morris, Paul G. Thomes, Jacy L. Kubik, Melissa S. Holzapfel, Armen Petrosyan – 6 September 2021 – Previous work from our laboratories has identified multiple defects in endocytosis, protein trafficking, and secretion, along with altered Golgi function after alcohol administration.

Subscribe to