Dual Targeting of Angipoietin‐1 and von Willebrand Factor by microRNA‐671‐5p Attenuates Liver Angiogenesis and Fibrosis

Le Yang, Wenhui Yue, Hang Zhang, Zhi Zhang, Renmin Xue, Chengbin Dong, Fuquan Liu, Na Chang, Lin Yang, Liying Li – 10 January 2022 – Angipoietin‐1 (Angpt1) and von Willebrand factor (VWF) are two important angiogenic molecules that can drive pathologic angiogenesis and progression of liver fibrosis in our previous study. MicroRNAs (miRs) participate in a variety of physiological and pathological processes, including angiogenesis. However, the critical miRs targeting Angpt1 or VWF and potential molecular mechanism underlying liver fibrosis–associated angiogenesis is not clear yet.

Hepatocyte TGF‐β Signaling Inhibiting WAT Browning to Promote NAFLD and Obesity Is Associated With Let‐7b‐5p

Jinfang Zhao, Lilin Hu, Wenfang Gui, Li Xiao, Weijun Wang, Jing Xia, Huiqian Fan, Zhonglin Li, Qingjing Zhu, Xiaohua Hou, Huikuan Chu, Ekihiro Seki, Ling Yang – 10 January 2022 – Transforming growth factor beta (TGF‐β) signaling in hepatocytes promotes steatosis and body weight gain. However, processes that TGF‐β signaling in hepatocytes promote pathological body weight gain in nonalcoholic fatty liver disease (NAFLD) are incompletely understood.

The RSPO‐LGR4/5‐ZNRF3/RNF43 module in liver homeostasis, regeneration, and disease

Stefano Annunziato, Tianliang Sun, Jan S. Tchorz – 9 January 2022 – WNT/β‐catenin signaling plays pivotal roles during liver development, homeostasis, and regeneration. Likewise, its deregulation disturbs metabolic liver zonation and is responsible for the development of a large number of hepatic tumors. Liver fibrosis, which has become a major health burden for society and a hallmark of NASH, can also be promoted by WNT/β‐catenin signaling.

Outcomes of Simultaneous Liver‐Kidney Transplantation Using Kidneys of Deceased Donors With Acute Kidney Injury

Ramesh K. Batra, Venkatesh K. Ariyamuthu, Malcolm P. MacConmara, Gaurav Gupta, Ahmet B. Gungor, Bekir Tanriover – 9 January 2022 – Outcomes from simultaneous liver‐kidney transplantation (SLKT) when using kidneys from donors with acute kidney injury (AKI) have not been studied. We studied 5344 SLKTs between May 1, 2007, and December 31, 2019, by using Organ Procurement and Transplantation Network registry data supplemented with United Network for Organ Sharing–DonorNet data.

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