Western Diet Changes Gut Microbiota and Ameliorates Liver Injury in a Mouse Model with Human‐Like Bile Acid Composition

Junichi Iwamoto, Akira Honda, Teruo Miyazaki, Tadakuni Monma, Hajime Ueda, Yukio Morishita, Sho‐ichiro Yara, Takeshi Hirayama, Tadashi Ikegami – 23 August 2021 – Western‐style high‐fat/high‐sucrose diet (HFHSD) changes gut microbiota and bile acid (BA) profiles. Because gut microbiota and BAs could influence each other, the mechanism of changes in both by HFHSD is complicated and remains unclear. We first aimed to clarify the roles of BAs in the HFHSD‐induced change of gut microbiota. Then, we studied the effects of the changed gut microbiota on BA composition and liver function.

Pretransplant Intensive Care Unit Management and Selection of Grade 3 Acute‐on‐Chronic Liver Failure Transplant Candidates

Baptiste Michard, Thierry Artzner, Mathilde Deridder, Camille Besch, Pietro Addeo, Vincent Castelain, Max Guillot, Marie‐Line Harlay, Jean‐Etienne Herbrecht, Ralf Janssen Langenstein, Maleka Schenck, Philippe Bachellier, Francis Schneider, François Faitot – 23 August 2021 – The aim of this study is to report on the liver transplantation (LT) activity and posttransplant outcome, over time, of patients with grade 3 acute‐on‐chronic liver failure (ACLF‐3) in a single transplant center performing a large number of LTs for patients with ACLF‐3.

Clinical Staging of Mass‐Forming Intrahepatic Cholangiocarcinoma: Computed Tomography Versus Magnetic Resonance Imaging

Yeun‐Yoon Kim, Suk‐Keu Yeom, Hyejung Shin, Sang Hyun Choi, Hyungjin Rhee, Ji Hoon Park, Eun‐Suk Cho, Sumi Park, Seung Soo Lee, Mi‐Suk Park – 23 August 2021 – We compared the performance of computed tomography (CT) and magnetic resonance imaging (MRI) for preoperative clinical staging of mass‐forming intrahepatic cholangiocarcinoma (iCCA), using the eighth American Joint Committee on Cancer (AJCC) system.

RORα Enhances Lysosomal Acidification and Autophagic Flux in the Hepatocytes

Hyeon‐Ji Kim, Yong‐Hyun Han, Ju‐Yeon Kim, Mi‐Ock Lee – 23 August 2021 – Lysosomes are intracellular acidic organelles with catabolic functions that contribute to the activation of autophagy. Although autophagy abnormality is associated with defects in lysosomal acidification during the progression of nonalcoholic fatty liver disease (NAFLD), the mechanisms of control of lysosomal acidification are not well understood at the molecular level.

Globo H Is a Promising Theranostic Marker for Intrahepatic Cholangiocarcinoma

Tsai‐Hsien Hung, Jung‐Tung Hung, Chiao‐En Wu, Yenlin Huang, Chien‐Wei Lee, Chau‐Ting Yeh, Yi‐Hsiu Chung, Fei‐Yun Lo, Li‐Chun Lai, John K. Tung, John Yu, Chun‐Nan Yeh, Alice L. Yu – 23 August 2021 – Recent studies support the development of cancer therapeutics to target Globo H‐ceramide, the most prevalent tumor‐associated carbohydrate antigen in epithelial cancers.

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