NAFLD polygenic risk score and risk of hepatocellular carcinoma in an East Asian population

Claire E. Thomas, Brenda Diergaarde, Allison L. Kuipers, Jennifer J. Adibi, Hung N. Luu, Xuling Chang, Rajkumar Dorajoo, Chew‐Kiat Heng, Chiea‐Chuen Khor, Renwei Wang, Aizhen Jin, Woon‐Puay Koh, Jian‐Min Yuan – 2 May 2022 – It is difficult to identify people with nonalcoholic fatty liver disease (NAFLD) who are at high risk for developing hepatocellular carcinoma (HCC). A polygenic risk score (PRS) for hepatic fat (HFC‐PRS) derived from non‐Asians has been reported to be associated with HCC risk in European populations.

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