Poor Awareness of Liver Disease Among Adults With NAFLD in the United States

Saleh A. Alqahtani, James M. Paik, Rakesh Biswas, Tamoore Arshad, Linda Henry, Zobair M. Younossi – 30 June 2021 – Population‐based studies that estimate awareness of nonalcoholic fatty liver disease (NAFLD) in the United States are scant. We aimed to understand public awareness of NAFLD and its temporal trends. Our study included 11,700 adults (18+ years old) from five National Health and Nutrition Examination Surveys (2007‐2016). NAFLD was determined by the improved Fatty Liver Index for the multiethnic U.S. population (US‐FLI) in the absence of secondary causes of liver disease.

Inhibition of Drug‐Induced Liver Injury in Mice Using a Positively Charged Peptide That Binds DNA

Pedro E. Marques, Sofie Vandendriessche, Thiago H.C. Oliveira, Helena Crijns, Mateus E. Lopes, Marfa Blanter, Sara Schuermans, Karen Yu, Fariba Poosti, Vincent Vanheule, Rik Janssens, Daiane Boff, Andreas J. Kungl, Gustavo B. Menezes, Mauro M. Teixeira, Paul Proost – 30 June 2021 – Hepatic cell death occurs in response to diverse stimuli such as chemical and physical damage. The exposure of intracellular contents such as DNA during necrosis induces a severe inflammatory response that has yet to be fully explored therapeutically.

Hepatic NF‐κB‐Inducing Kinase and Inhibitor of NF‐κB Kinase Subunit α Promote Liver Oxidative Stress, Ferroptosis, and Liver Injury

Xiao Zhong, Zhiguo Zhang, Hong Shen, Yi Xiong, Yatrik M. Shah, Yong Liu, Xue‐Gong Fan, Liangyou Rui – 30 June 2021 – Drug‐induced hepatotoxicity limits development of new effective medications. Drugs and numerous endogenous/exogenous agents are metabolized/detoxified by hepatocytes, during which reactive oxygen species (ROS) are generated as a by‐product. ROS has broad adverse effects on liver function and integrity, including damaging hepatocyte proteins, lipids, and DNA and promoting liver inflammation and fibrosis. ROS in concert with iron overload drives ferroptosis.

High Prevalence of Transjugular Intrahepatic Portosystemic Shunt Creation Without Prior Endoscopy During Acute Variceal Bleeding Hospitalization in the United States

Premal S. Trivedi, Alexandria M. Jensen, Matthew A. Brown, Rustain L. Morgan, Richard C. Lindrooth, Robert K. Ryu, P. Michael Ho, Michael S. Kriss – 30 June 2021 – Current clinical guidelines by both American Association for the Study of Liver Disease and European Association for the Study of the Liver recommend endoscopy in all patients admitted with acute variceal bleeding within 12 hours of admission. Transjugular intrahepatic portosystemic shunt (TIPS) creation may be considered in patients at high risk if hemorrhage cannot be controlled endoscopically.

Involvement of TIGIT in Natural Killer Cell Exhaustion and Immune Escape in Patients and Mouse Model With Liver Echinococcus multilocularis Infection

Chuanshan Zhang, Hui Wang, Jing Li, Xinling Hou, Linghui Li, Wei Wang, Yang Shi, Dewei Li, Liang Li, Zhibin Zhao, Liang Li, Tuerganaili Aji, Renyong Lin, Yingmei Shao, Dominique A. Vuitton, Zhigang Tian, Haoyu Sun, Hao Wen – 29 June 2021

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