Metabolic Complications in Liver Transplantation Recipients: How We Can Optimize Long‐Term Survival

Amirhossein Azhie, Priya Sheth, Ahmed Hammad, Minna Woo, Mamatha Bhat – 23 June 2021 – Liver transplantation (LT) recipients have experienced a significant improvement in short‐term survival during the past 3 decades attributed to advancements in surgical techniques, perioperative management, and effective immunosuppressive regimens. However, long‐term survival is affected by a high incidence of metabolic disorders and their consequences, including cardiovascular disease (CVD) and malignancies.

Allograft Fibrosis After Pediatric Liver Transplantation: Incidence, Risk Factors, and Evolution

Roberta Angelico, Marco Spada, Daniela Liccardo, Domiziana Pedini, Chiara Grimaldi, Andrea Pietrobattista, Maria Sole Basso, Claudia Della Corte, Antonella Mosca, Maria Cristina Saffioti, Rita Alaggio, Giuseppe Maggiore, Manila Candusso, Paola Francalanci – 22 June 2021 – Allograft fibrosis (AF) after pediatric liver transplantation (pLT) is frequent, but its dynamics are unclear. Our aim was to assess the evolution and risk factors of AF after pLT.

On the Mechanisms of Biliary Flux

Nachiket Vartak, Dirk Drasdo, Fabian Geisler, Tohru Itoh, Ronald P.J.Oude Elferink, Stan F.J. Graaf, John Chiang, Verena Keitel, Michael Trauner, Peter Jansen, Jan G. Hengstler – 22 June 2021 – Since the late 1950s, transport of bile in the liver has been described by the “osmotic concept,” according to which bile flows into the canaliculi toward the ducts, countercurrent to the blood flow in the sinusoids. However, because of the small size of canaliculi, it was so far impossible to observe, let alone to quantify this process.

Modeling Phenotypic Heterogeneity of Glycogen Storage Disease Type 1a Liver Disease in Mice by Somatic CRISPR/CRISPR‐associated protein 9–Mediated Gene Editing

Martijn G.S. Rutten, Terry G.J. Derks, Nicolette C.A. Huijkman, Trijnie Bos, Niels J. Kloosterhuis, Kees C.W.A. Kolk, Justina C. Wolters, Mirjam H. Koster, Laura Bongiovanni, Rachel E. Thomas, Alain Bruin, Bart Sluis, Maaike H. Oosterveer – 21 June 2021

Immunomodulatory Effects of Lenvatinib Plus Anti–Programmed Cell Death Protein 1 in Mice and Rationale for Patient Enrichment in Hepatocellular Carcinoma

Laura Torrens, Carla Montironi, Marc Puigvehí, Agavni Mesropian, Jack Leslie, Philipp K. Haber, Miho Maeda, Ugne Balaseviciute, Catherine E. Willoughby, Jordi Abril‐Fornaguera, Marta Piqué‐Gili, Miguel Torres‐Martín, Judit Peix, Daniel Geh, Erik Ramon‐Gil, Behnam Saberi, Scott L. Friedman, Derek A. Mann, Daniela Sia, Josep M. Llovet – 21 June 2021

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