Assessment of the Frail Patient With End‐Stage Liver Disease: A Practical Overview of Sarcopenia, Physical Function, and Disability

Felicity R Williams, Don Milliken, Jennifer C Lai, Matthew J Armstrong – 25 February 2021 – Frailty has emerged as a powerful predictor of clinical outcomes (e.g., decompensation, hospitalization, mortality) in patients with end‐stage liver disease (ESLD). It is therefore of paramount importance that all patients with ESLD undergo an assessment of frailty, to support life and death decision making (i.e., candidacy for critical care, transplantation) and aid with prioritization of evolving prehabilitation services (i.e., nutrition, physiotherapy, psychotherapy).

Diagnostic Performance of Transient Elastography in Biliary Atresia Among Infants With Cholestasis

Yin‐Ann Boo, Mei‐Hwei Chang, Yung‐Ming Jeng, Shinn‐Forng Peng, Wen‐Ming Hsu, Wen‐Hsi Lin, Huey‐Ling Chen, Yen‐Hsuan Ni, Hong‐Yuan Hsu, Jia‐Feng Wu – 25 February 2021 – Biliary atresia (BA) is a challenging liver disease in infancy. Early diagnosis of BA is important for timely hepatoportoenterostomy. We evaluated the age‐specific diagnostic performance of transient elastography (TE) with a liver stiffness measurement (LSM) greater than 7.7 kPa in BA among infants with cholestasis.

Coagulopathy, Bleeding Events, and Outcome According to Rotational Thromboelastometry in Patients With Acute Liver Injury/Failure

R. Todd Stravitz, Robert J. Fontana, Caitlyn Meinzer, Valerie Durkalski‐Mauldin, A. James Hanje, Jody Olson, David Koch, Bilal Hamid, Michael L. Schilsky, Brendan McGuire, Daniel Ganger, Iris Liou, Constantine J. Karvellas, Jody A. Rule, Ton Lisman, Kristin Clasen, Adrian Reuben, Michael Cripps, William M. Lee, ALF Study Group – 25 February 2021

Hepatobiliary Organoids and Their Applications for Studies of Liver Health and Disease: Are We There Yet?

Junya Shiota, Linda C. Samuelson, Nataliya Razumilava – 25 February 2021 – Organoid culture systems have emerged as a frontier technology in liver and biliary research. These three‐dimensional (3D) cell cultures derived from pluripotent and adult hepatobiliary cells model organ structure and function. Building on gastrointestinal organoid establishment, hepatobiliary organoid cultures were generated from mouse leucine‐rich repeat–containing G‐protein–coupled receptor 5–positive liver progenitor cells.

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