The Patient’s Perspective in Cirrhosis: Unmet Supportive Care Needs Differ by Disease Severity, Etiology, and Age

Patricia C. Valery, Christina M. Bernardes, Benjamin Mckillen, Samath Amarasena, Katherine A. Stuart, Gunter Hartel, Paul J. Clark, Richard Skoien, Tony Rahman, Leigh Horsfall, Kelly Hayward, Rohit Gupta, Andrew Lee, Leshni Pillay, Elizabeth E. Powell – 5 February 2021 – Patients with cirrhosis have significant physical, psychological, and practical needs. We documented patients’ perceived need for support with these issues and the differences with increasing liver disease severity, etiology, and age.

Exosome‐Like Nanoparticles From Lactobacillus rhamnosusGG Protect Against Alcohol‐Associated Liver Disease Through Intestinal Aryl Hydrocarbon Receptor in Mice

Zelin Gu, Fengyuan Li, Yunhuan Liu, Mengwei Jiang, Lihua Zhang, Liqing He, Daniel W. Wilkey, Michael Merchant, Xiang Zhang, Zhong‐Bin Deng, Shao‐Yu Chen, Shirish Barve, Craig J. McClain, Wenke Feng – 4 February 2021 – Alcohol‐associated liver disease (ALD) is a major cause of mortality. Gut barrier dysfunction–induced bacterial translocation and endotoxin release contribute to the pathogenesis of ALD. Probiotic Lactobacillus rhamnosus GG (LGG) is known to be beneficial on experimental ALD by reinforcing the intestinal barrier function.

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