Inclusive Quantification Assay of Serum Des‐γ‐Carboxyprothrombin Proteoforms for Hepatocellular Carcinoma Surveillance by Targeted Mass Spectrometry

Jihyeon Lee, Young‐Suk Lim, Jeong‐Hoon Lee, Geum‐Youn Gwak, Misol Do, Injoon Yeo, Dongyoon Shin, Dohyun Han, Taesung Park, Youngsoo Kim – 11 June 2021 – Hepatocellular carcinoma (HCC) is a malignant cancer with one of the highest mortality rates. Des‐γ‐carboxyprothrombin (DCP) is an HCC serologic surveillance marker that can complement the low sensitivity of alpha‐fetoprotein (AFP). DCP exists in the blood as a mixture of proteoforms from an impaired carboxylation process at glutamic acid (Glu) residues within the N‐terminal domain.

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Jasmohan S. Bajaj, Guadalupe Garcia‐Tsao, Patrick S. Kamath, Jacqueline G. O’Leary, K. Rajender Reddy, Florence Wong – 9 June 2021

Obeticholic Acid Decreases Intestinal Content of Enterococcus in Rats With Cirrhosis and Ascites

Kathleen Yan, Adelina Hung, Caitlin Parmer, Hui Yang, Dhanpat Jain, Bentley Lim, Andrew L. Goodman, Guadalupe Garcia‐Tsao – 9 June 2021 – The intestinal microbiome and bacterial translocation (BT), the passage of microorganisms from the gut lumen to mesenteric lymph nodes and other extra‐intestinal sites, are main mechanisms implicated in liver injury and further decompensation in patients with cirrhosis. We hypothesized that obeticholic acid (OCA), a semisynthetic bile acid, would change the microbiome composition and reduce bacterial translocation in experimental cirrhosis.

The Level of Alcohol Consumption in the Prior Year Does Not Impact Clinical Outcomes in Patients With Alcohol‐Associated Hepatitis

Jessica A. Musto, Jens Eickhoff, Meritxell Ventura‐Cots, Juan G. Abraldes, Francisco Bosques‐Padilla, Elizabeth C. Verna, Robert S. Brown, Victor Vargas, Jose Altamirano, Juan Caballería, Debbie Shawcross, Alexandre Louvet, Philippe Mathurin, Guadalupe Garcia‐Tsao, Bernd Schnabl, Ramon Bataller, Michael R. Lucey – 9 June 2021 – The 10‐item Alcohol Use Disorders Identification Test (AUDIT‐10) and its shorter form, AUDIT‐Consumption (AUDIT‐C), are questionnaires used to characterize severity of drinking.

Immune Activation Induces Telomeric DNA Damage and Promotes Short‐Lived Effector T Cell Differentiation in Chronic HCV Infection

Lam Nhat Nguyen, Lam Ngoc Thao Nguyen, Juan Zhao, Madison Schank, Xindi Dang, Dechao Cao, Sushant Khanal, Bal Krishna Chand Thakuri, Jinyu Zhang, Zeyuan Lu, Xiao Y. Wu, Mohamed El Gazzar, Shunbin Ning, Ling Wang, Jonathan P. Moorman, Zhi Q. Yao – 9 June 2021

Key Characteristics of Human Hepatotoxicants as a Basis for Identification and Characterization of the Causes of Liver Toxicity

Ivan Rusyn, Xabier Arzuaga, Russell C. Cattley, J. Christopher Corton, Stephen S. Ferguson, Patricio Godoy, Kathryn Z. Guyton, Neil Kaplowitz, Salman R. Khetani, Ruth A. Roberts, Robert A. Roth, Martyn T. Smith – 8 June 2021 – Hazard identification regarding adverse effects on the liver is a critical step in safety evaluations of drugs and other chemicals. Current testing paradigms for hepatotoxicity rely heavily on preclinical studies in animals and human data (epidemiology and clinical trials).

Surgical Debulking for Refractory Hyperammonemic Encephalopathy in Fibrolamellar Hepatocellular Carcinoma

Vinod Solipuram, Marina Baretti, Alexander Y. Kim, Lucy X. Chen, Jill A. Fahrner, Meral Gunay‐Aygun, Xiao P. Peng, Dylan Hardenbergh, Anna Ferguson, Paige Griffith, Yuxuan Wang, Madelena Brancati, Harish Gopalakrishna, Tomoaki Kato, Chris Shubert, Daniel Laheru, Mark Yarchoan – 8 June 2021

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