Regulatory T Cell Therapy Following Liver Transplantation

Jiongjie Yu, Zhikun Liu, Changbiao Li, Qiang Wei, Shusen Zheng, Kourosh Saeb‐Parsy, Xiao Xu – 22 November 2020 – Liver transplantation (LT) is considered the gold standard of curative treatment for patients with end‐stage liver disease or nonresectable hepatic malignant tumors. Rejection after LT is the main nontechnical factor affecting the prognosis of recipients. Medical and surgical advances, combined with improved immunosuppression with drugs such as calcineurin inhibitors (CNIs), have contributed to an increase in 1‐year graft survival to around 80%.

Bleeding Outcomes Following Transesophageal Echocardiography in Patients With Cirrhosis and Esophageal Varices

Jordan S. Sack, Michael Li, Stephen D. Zucker – 21 November 2020 – Despite scant evidence, current guidelines indicate that esophageal varices are a relative contraindication to transesophageal echocardiography (TEE). The aim of this study is to compare the risk of gastrointestinal bleeding following TEE among cirrhotic patients with and without endoscopically‐documented esophageal varices. This is a retrospective analysis of patients with cirrhosis who underwent upper endoscopy within 4 years of TEE at five institutions between January 2000 and March 2020.

Fecal Microbiota Transplant in Cirrhosis Reduces Gut Microbial Antibiotic Resistance Genes: Analysis of Two Trials

Jasmohan S. Bajaj, Amirhossein Shamsaddini, Andrew Fagan, Richard K. Sterling, Edith Gavis, Alexander Khoruts, Michael Fuchs, Hannah Lee, Masoumeh Sikaroodi, Patrick M. Gillevet – 21 November 2020 – Antibiotic resistance leads to poor outcomes in cirrhosis. Fecal microbiota transplant (FMT) is associated with reduction in antibiotic resistance gene (ARG) burden in patients without cirrhosis; however, the impact in cirrhosis is unclear.

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