Bile Acid Profiles in Primary Sclerosing Cholangitis and Their Ability to Predict Hepatic Decompensation

Omar Y. Mousa, Brian D. Juran, Bryan M. McCauley, Mette N. Vesterhus, Trine Folseraas, Coleman T. Turgeon, Ahmad H. Ali, Erik M. Schlicht, Elizabeth J. Atkinson, Chang Hu, Denise Harnois, Elizabeth J. Carey, Andrea A. Gossard, Devin Oglesbee, John E. Eaton, Nicholas F. LaRusso, Gregory J. Gores, Tom H. Karlsen, Konstantinos N. Lazaridis – 23 November 2020

Frailty Is a Risk Factor for Postoperative Mortality in Patients With Cirrhosis Undergoing Diverse Major Surgeries

Nadim Mahmud, David E. Kaplan, Tamar H. Taddei, David S. Goldberg – 23 November 2020 – With a rising burden of cirrhosis surgeries, understanding risk factors for postoperative mortality is more salient than ever. The role of baseline frailty has not been assessed in this context. We evaluated the association between patient frailty and postoperative risk among diverse patients with cirrhosis and determined if frailty improves prognostication of cirrhosis surgical risk scores. This was a retrospective cohort study of U.S.

Targeting the Four Pillars of Enterohepatic Bile Salt Cycling; Lessons From Genetics and Pharmacology

Roni F. Kunst, Henkjan J. Verkade, Ronald P.J. Oude Elferink, Stan F.J. Graaf – 22 November 2020 – Bile salts play a pivotal role in lipid homeostasis, are sensed by specialized receptors, and have been implicated in various disorders affecting the gut or liver. They may play a role either as culprit or as potential panacea. Four very efficient transporters mediate most of the hepatic and intestinal bile salt uptake and efflux, and are each essential for the efficient enterohepatic circulation of bile salts.

Dual Targeting of G9a and DNA Methyltransferase‐1 for the Treatment of Experimental Cholangiocarcinoma

Leticia Colyn, Marina Bárcena‐Varela, Gloria Álvarez‐Sola, M. Ujue Latasa, Iker Uriarte, Eva Santamaría, Jose M. Herranz, Alvaro Santos‐Laso, Maria Arechederra, Mikel Ruiz de Gauna, Patricia Aspichueta, Matteo Canale, Andrea Casadei‐Gardini, Maria Francesconi, Simone Carotti, Sergio Morini, Leonard J. Nelson, Maria J. Iraburu, Chaobo Chen, Bruno Sangro, Jose J.G. Marin, Maria L. Martinez‐Chantar, Jesus M. Banales, Robert Arnes‐Benito, Meritxell Huch, John M. Patino, Altaf A.

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