Dual Targeting of G9a and DNA Methyltransferase‐1 for the Treatment of Experimental Cholangiocarcinoma

Leticia Colyn, Marina Bárcena‐Varela, Gloria Álvarez‐Sola, M. Ujue Latasa, Iker Uriarte, Eva Santamaría, Jose M. Herranz, Alvaro Santos‐Laso, Maria Arechederra, Mikel Ruiz de Gauna, Patricia Aspichueta, Matteo Canale, Andrea Casadei‐Gardini, Maria Francesconi, Simone Carotti, Sergio Morini, Leonard J. Nelson, Maria J. Iraburu, Chaobo Chen, Bruno Sangro, Jose J.G. Marin, Maria L. Martinez‐Chantar, Jesus M. Banales, Robert Arnes‐Benito, Meritxell Huch, John M. Patino, Altaf A.

Targeting the Four Pillars of Enterohepatic Bile Salt Cycling; Lessons From Genetics and Pharmacology

Roni F. Kunst, Henkjan J. Verkade, Ronald P.J. Oude Elferink, Stan F.J. Graaf – 22 November 2020 – Bile salts play a pivotal role in lipid homeostasis, are sensed by specialized receptors, and have been implicated in various disorders affecting the gut or liver. They may play a role either as culprit or as potential panacea. Four very efficient transporters mediate most of the hepatic and intestinal bile salt uptake and efflux, and are each essential for the efficient enterohepatic circulation of bile salts.

Fecal Microbiota Transplant in Cirrhosis Reduces Gut Microbial Antibiotic Resistance Genes: Analysis of Two Trials

Jasmohan S. Bajaj, Amirhossein Shamsaddini, Andrew Fagan, Richard K. Sterling, Edith Gavis, Alexander Khoruts, Michael Fuchs, Hannah Lee, Masoumeh Sikaroodi, Patrick M. Gillevet – 21 November 2020 – Antibiotic resistance leads to poor outcomes in cirrhosis. Fecal microbiota transplant (FMT) is associated with reduction in antibiotic resistance gene (ARG) burden in patients without cirrhosis; however, the impact in cirrhosis is unclear.

Cirrhosis and Severe Acute Respiratory Syndrome Coronavirus 2 Infection in US Veterans: Risk of Infection, Hospitalization, Ventilation, and Mortality

George N. Ioannou, Peter S. Liang, Emily Locke, Pamela Green, Kristin Berry, Ann M. O’Hare, Javeed A. Shah, Kristina Crothers, McKenna C. Eastment, Vincent S. Fan, Jason A. Dominitz – 21 November 2020

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