Clinicopathologic Characteristics of Centrilobular Injury in Pediatric Liver Transplantation
Iván A. González, Hsiang‐Chih Lu, Zahra Alipour, Sakil S. Kulkarni, Janis M. Stoll, Kim H.H. Liss, Louis P. Dehner, Mai He – 30 November 2020 – Centrilobular injury (CLI) is defined as the presence of perivenular mononuclear inflammation, hepatocyte dropout, and extravasated erythrocytes. In pediatric liver allografts, CLI has been associated with advanced fibrosis and chronic rejection (CR). We sought to better characterize the clinicopathologic features of CLI in the setting of T cell–mediated rejection (TCMR) and its association with complement component 4d (C4d) deposition.