Platelets Stimulate Liver Regeneration in a Rat Model of Partial Liver Transplantation

Chen Liang, Kazuhiro Takahashi, Kinji Furuya, Tatsuya Oda, Nobuhiro Ohkohchi – 4 December 2020 – Living donor liver transplantation (LDLT) is sometimes associated with impaired regeneration and severe ischemia/reperfusion injury (IRI) in the graft, resulting in small‐for‐size syndrome (SFSS). Platelets were previously reported to stimulate liver regeneration in models of hepatectomy, but the evidence in partial liver transplantation (LT) is lacking.

LiverLearning®: 2020 Webinar: Chronic Hepatitis C 500: The Advanced Course

Many HCV-infected patients suffer from decompensated cirrhosis. Aside from appropriate care of their cirrhosis, these patients may benefit from therapy, irrespective of liver transplant candidacy. Providers outside of transplant centers, should be knowledgeable about pertinent aspects of liver transplants for their patients. Finally, several groups have reported unusual genotype subtypes which are less responsive to existing DAA regimens. This webinar is designed for the experienced HCV-treatment provider.Brian Pearlman Brian L.

Molecular Profiling of Decompensated Cirrhosis by a Novel MicroRNA Signature

Ana Garcia Garcia de Paredes, Nicolo Manicardi, Luis Tellez, Luis Ibañez, Felix Royo, Javier Bermejo, Carolina Blanco, Constantino Fondevila, Val Fernandez Lanza, Laura Garcia‐Bermejo, Juan Manuel Falcon‐Perez, Rafael Bañares, Jordi Gracia‐Sancho, Agustin Albillos – 2 December 2020 – Noninvasive staging of decompensated cirrhosis is an unmet clinical need. The aims of this study were to characterize and validate a novel microRNA (miRNA) signature to stage decompensated cirrhosis and predict the portal pressure and systolic cardiac response to nonselective beta‐blockers (NSBBs).

Histidine‐Rich Glycoprotein Alleviates Liver Ischemia/Reperfusion Injury in Mice With Nonalcoholic Steatohepatitis

Jie Guo, Tomohiko Akahoshi, Yukie Mizuta, Masaharu Murata, Sayoko Narahara, Takahito Kawano, Yoshihiro Nagao, Shuo Zhang, Morimasa Tomikawa, Hirofumi Kawanaka, Makoto Hashizume – 1 December 2020 – Hepatic ischemia/reperfusion injury (IRI) is a major complication of liver surgery and transplantation, especially in patients with nonalcoholic steatohepatitis (NASH). The mechanism of NASH susceptibility to IRI has not been fully clarified. We investigated the role of liver‐produced histidine‐rich glycoprotein (HRG) in NASH IRI.

Liver Transplantation for Acute Intermittent Porphyria

Mattias Lissing, Greg Nowak, René Adam, Vincent Karam, Alexander Boyd, Laurent Gouya, Wouter Meersseman, Espen Melum, Urszula Ołdakowska‐Jedynak, Florian P. Reiter, Jordi Colmenero, Rosario Sanchez, Uta Herden, Janneke Langendonk, Paolo Ventura, Helena Isoniemi, Olivier Boillot, Felix Braun, Stéphanie Perrodin, Elizabeth Mowlem, Staffan Wahlin, European Liver and Intestine Transplant Association – 1 December 2020 – Recurrent attacks of acute intermittent porphyria (AIP) result in poor quality of life and significant risks of morbidity and mortality.

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