Improvements in Disease‐Specific Health‐Related Quality of Life of Pediatric Liver Transplant Recipients During Immunosuppression Withdrawal

Saeed Mohammad, Shikha S. Sundaram, Kristen Mason, Steven Lobritto, Mercedes Martinez, Yumirle P. Turmelle, John Bucuvalas, Sandy Feng, Estella M. Alonso – 6 December 2020 – Long‐term immunosuppression (IS) leads to systemic complications affecting health‐related quality of life (HRQOL) in pediatric liver transplantation (LT) recipients. We serially assessed HRQOL using the PedsQL Generic and Multidimensional Fatigue Scales and Family Impact and Transplant Modules as part of a multicenter prospective immunosuppression withdrawal (ISW) trial between 2012 and 2018.

Early Allograft Dysfunction Increases Hospital Associated Costs After Liver Transplantation—A Propensity Score–Matched Analysis

Simon Moosburner, Igor M. Sauer, Frank Förster, Thomas Winklmann, Joseph Maria George Vernon Gassner, Paul V. Ritschl, Robert Öllinger, Johann Pratschke, Nathanael Raschzok – 5 December 2020 – Concepts to ameliorate the continued mismatch between demand for liver allografts and supply include the acceptance of allografts that meet extended donor criteria (ECD). ECD grafts are generally associated with an increased rate of complications such as early allograft dysfunction (EAD).

Platelets Stimulate Liver Regeneration in a Rat Model of Partial Liver Transplantation

Chen Liang, Kazuhiro Takahashi, Kinji Furuya, Tatsuya Oda, Nobuhiro Ohkohchi – 4 December 2020 – Living donor liver transplantation (LDLT) is sometimes associated with impaired regeneration and severe ischemia/reperfusion injury (IRI) in the graft, resulting in small‐for‐size syndrome (SFSS). Platelets were previously reported to stimulate liver regeneration in models of hepatectomy, but the evidence in partial liver transplantation (LT) is lacking.

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