The Stanford Integrated Psychosocial Assessment for Transplant Is Associated With Outcomes Before and After Liver Transplantation

Sasha Deutsch‐Link, Ethan M. Weinberg, Therese Bittermann, Mackenzie McDougal, Aniket Dhariwal, Lauren S. Jones, Robert M. Weinrieb, Arpita G. Banerjee, Senayish Addis, Marina Serper – 15 December 2020 – The Stanford Integrated Psychosocial Assessment for Transplant (SIPAT) is a standardized psychosocial evaluation tool used in liver transplantation (LT) evaluation. We assessed the impact of the SIPAT score and subdomains on transplant waitlisting decisions and post‐LT outcomes including immunosuppression (IS) nonadherence, biopsy‐proven rejection, andmortality/graft failure.

Liver Transplant Recipient, Caregiver, and Provider Perceptions of Cardiovascular Disease and Related Risk Factors After Transplant

Lisa B. VanWagner, Elisa Gordon, Lindsay Adamski, Megan Kosirog, Amna Daud, Daniel J. Finn, Donald M. Lloyd‐Jones, Jane L. Holl – 14 December 2020 – Liver transplant recipients (LTRs) are at high risk for cardiovascular disease (CVD). We sought to characterize LTR, informal caregiver, and health care provider perceptions about CVD care after liver transplantation (LT) to inform the design of solutions to improve care.

Neurodegeneration in Hepatic and Neurologic Wilson’s Disease

André Viveiros, Vincent Beliveau, Marlene Panzer, Benedikt Schaefer, Bernhard Glodny, Benjamin Henninger, Herbert Tilg, Heinz Zoller, Christoph Scherfler – 14 December 2020 – Clinical presentation of Wilson disease (WD) includes hepatic and neurologic manifestations. This study compares subcortical brain regions by magnetic resonance imaging in patients with WD and without neurological symptoms. Distinct atrophy affecting the basal ganglia, accumbens, and hippocampus was present in neurological WD. Cerebellar atrophy was observed in hepatic WD without neurological symptoms.

Two Faces of Neutrophils in Liver Disease Development and Progression

Yeonhee Cho, Gyongyi Szabo – 13 December 2020 – Neutrophils, the most abundant type of leukocyte in human blood, play a major role in host defense against invading pathogens and in sterile injury. Neutrophil infiltration is characteristic of inflammation because of its antimicrobial and cytotoxic activities. Neutrophils also actively participate in the resolution of inflammation and subsequent tissue repair by acting as a critical mediator between the inflammation and resolution phases of tissue damage.

Reduced Clot Stability by Thromboelastography as a Potential Indicator of Procedure‐Related Bleeding in Decompensated Cirrhosis

Alberto Zanetto, Henry M. Rinder, Marco Senzolo, Paolo Simioni, Guadalupe Garcia‐Tsao – 12 December 2020 – In patients with decompensated cirrhosis, procedure‐related bleeding is a potentially lethal complication. Routine coagulation tests such as international normalized ratio and platelet count do not predict bleeding risk. We investigated whether thromboelastography (TEG) can identify patients with cirrhosis who are at risk of procedure‐related bleeding.

Posttransplant Outcomes in Older Patients With Hepatocellular Carcinoma Are Driven by Non–Hepatocellular Carcinoma Factors

Nia Adeniji, Vinodhini Arjunan, Vijay Prabhakar, Ajitha Mannalithara, Tara Ghaziani, Aijaz Ahmed, Paul Kwo, Mindie Nguyen, Marc L. Melcher, Ronald W. Busuttil, Sander S. Florman, Brandy Haydel, Richard M. Ruiz, Goran B. Klintmalm, David D. Lee, C. Burcin Taner, Maarouf A. Hoteit, Elizabeth C. Verna, Karim J. Halazun, Amit D. Tevar, Abhinav Humar, William C. Chapman, Neeta Vachharajani, Federico Aucejo, Trevor L. Nydam, James F. Markmann, Constance Mobley, Mark Ghobrial, Alan N. Langnas, Carol A. Carney, Jennifer Berumen, Gabriel T. Schnickel, Debra L. Sudan, Johnny C.

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