Predictors of Outcomes of Patients Referred to a Transplant Center for Urgent Liver Transplantation Evaluation

Omar Alshuwaykh, Allison Kwong, Aparna Goel, Amanda Cheung, Renumathy Dhanasekaran, Aijaz Ahmed, Tami Daugherty, Deepti Dronamraju, Radhika Kumari, W. Ray Kim, Mindie H. Nguyen, Carlos O. Esquivel, Waldo Concepcion, Marc Melcher, Andy Bonham, Thomas Pham, Amy Gallo, Paul Yien Kwo – 27 December 2020 – Liver transplantation (LT) is definitive treatment for end‐stage liver disease. This study evaluated factors predicting successful evaluation in patients transferred for urgent inpatient LT evaluation.

Therapeutic Potential of TLR8 Agonist GS‐9688 (Selgantolimod) in Chronic Hepatitis B: Remodeling of Antiviral and Regulatory Mediators

Oliver E. Amin, Emily J. Colbeck, Stephane Daffis, Shahzada Khan, Dhivya Ramakrishnan, Divya Pattabiraman, Ruth Chu, Holly Micolochick Steuer, Sophie Lehar, Leanne Peiser, Adam Palazzo, Christian Frey, Jessica Davies, Hassan Javanbakht, William M.C. Rosenberg, Simon P. Fletcher, Mala K. Maini, Laura J. Pallett – 25 December 2020

Fatty Acid Desaturase 1 Influences Hepatic Lipid Homeostasis by Modulating the PPARα‐FGF21 Axis

Shaminie Athinarayanan, Yang‐Yi Fan, Xiaokun Wang, Evelyn Callaway, Defeng Cai, Naga Chalasani, Robert S. Chapkin, Wanqing Liu – 25 December 2020 – The fatty acid desaturase 1 (FADS1), also known as delta‐5 desaturase (D5D), is one of the rate‐limiting enzymes involved in the desaturation and elongation cascade of polyunsaturated fatty acids (PUFAs) to generate long‐chain PUFAs (LC‐PUFAs). Reduced function of D5D and decreased hepatic FADS1 expression, as well as low levels of LC‐PUFAs, were associated with nonalcoholic fatty liver disease.

Overexpression of Mothers Against Decapentaplegic Homolog 7 Activates the Yes‐Associated Protein/NOTCH Cascade and Promotes Liver Carcinogenesis in Mice and Humans

Haichuan Wang, Xinhua Song, Haotian Liao, Pan Wang, Yi Zhang, Li Che, Jie Zhang, Yi Zhou, Antonio Cigliano, Cindy Ament, Daphne Superville, Silvia Ribback, Melissa Reeves, Giovanni M. Pes, Binyong Liang, Hong Wu, Matthias Evert, Diego F. Calvisi, Yong Zeng, Xin Chen – 24 December 2020

Hepatology Highlights

Adam Buckholz, Robert S. Brown, Hirsh Trivedi, Muzammil M. Khan, Hira Hanif, Daryl T.Y. Lau, Amneet Hans, Giorgio Roccaro, Joseph F. Pisa, Nidhi Jalan‐Sakrikar, Robert E. Schwartz, Nicholas W. Russo, Tejasav S. Sehrawat, Enis Kostallari, Adebowale O. Bamidele, Gopanandan Parthasarathy – 23 December 2020

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