Association Between Transient Elastography and Controlled Attenuated Parameter and Liver Ultrasound in Children With Cystic Fibrosis

Wen Ye, Daniel H. Leung, Jean P. Molleston, Simon C. Ling, Karen F. Murray, Jennifer L. Nicholas, Suiyuan Huang, Boaz W. Karmazyn, Roger K. Harned, Prakash Masand, Adina L. Alazraki, Oscar M. Navarro, Randolph K. Otto, Joseph J Palermo, Alexander J Towbin, Estella M. Alonso, Wikrom W. Karnsakul, Sarah Jane Schwarzenberg, Glenn F Seidel, Marilyn Siegel, John C. Magee, Michael R. Narkewicz, A. Jay Freeman – 12 May 2021 – Methods to identify children with cystic fibrosis (CF) at risk for development of advanced liver disease are lacking.

Usefulness of the Stroop Test in Diagnosing Minimal Hepatic Encephalopathy and Predicting Overt Hepatic Encephalopathy

Tatsunori Hanai, Makoto Shiraki, Kayoko Nishimura, Takao Miwa, Toshihide Maeda, Yui Ogiso, Kenji Imai, Atsushi Suetsugu, Koji Takai, Masahito Shimizu – 12 May 2021 – Minimal hepatic encephalopathy (MHE) adversely affects the clinical outcomes of patients with liver cirrhosis. This prospective study aimed to evaluate the utility of the Stroop test in the diagnosis of MHE and prediction of overt hepatic encephalopathy (OHE) in Japanese patients with cirrhosis. We enrolled 152 patients who underwent the Stroop test between November 2018 and February 2020.

Excellent Outcome in Living Donor Liver Transplantation: Treating Patients With Acute‐on‐Chronic Liver Failure

Yu‐Chen Wang, Chee‐Chien Yong, Chih‐Che Lin, Humaira Alam, Faisal Naseer, Yu‐Hung Lin, Cheng‐Hsi Yeh, Shih‐Ho Wang, Tsan‐Shiun Lin, Ting‐Lung Lin, Wei‐Feng Lee, Yi‐Chia Chan, Chih‐Chi Wang, Chao‐Long Chen – 11 May 2021 – Acute‐on‐chronic liver failure (ACLF) is a fatal condition, and liver transplantation (LT) is a vital option for these patients. However, the result of living donor LT (LDLT) for ACLF is not well investigated. This study investigated the outcomes of LDLT in patients with ACLF compared with patients without ACLF.

Improvements of Fibrosis and Disease Activity Are Associated With Improvement of Patient‐Reported Outcomes in Patients With Advanced Fibrosis Due to Nonalcoholic Steatohepatitis

Zobair M. Younossi, Maria Stepanova, Mazen Noureddin, Kris V. Kowdley, Simone I. Strasser, Anita Kohli, Peter Ruane, Mitchell L. Shiffman, Aasim Sheikh, Nadege Gunn, Stephen H. Caldwell, Ryan S. Huss, Robert P. Myers, Vincent Wai‐Sun Wong, Naim Alkhouri, Zachary Goodman, Rohit Loomba – 11 May 2021 – Patient‐reported outcomes (PROs) are important endpoints for clinical trials. The impact of investigational drugs on PROs of patients with advanced nonalcoholic steatohepatitis (NASH) was investigated.

Doxycycline Significantly Enhances Induction of Induced Pluripotent Stem Cells to Endoderm by Enhancing Survival Through Protein Kinase B Phosphorylation

Caitlin Peaslee, Cristina Esteva‐Font, Tao Su, Antonio Munoz‐Howell, Caroline C. Duwaerts, Zhe Liu, Sneha Rao, Ke Liu, Marisa Medina, Julie B. Sneddon, Jacquelyn J. Maher, Aras N. Mattis – 11 May 2021

Management of Biliary Stricture in Pediatric Liver Transplantation Patients: Long‐Term Outcomes

Kimberly L. Yan, Antoinette S. Gomes, Phillip A. Monteleone, Robert S. Venick, Sue V. McDiarmid, Jorge H. Vargas, Douglas G. Farmer – 10 May 2021 – Postoperative biliary complications have been reported to occur in 10% to 33% of pediatric liver transplantation (LT) recipients. Percutaneous intervention has become the primary treatment method for these complications; however, the efficacy and outcomes of these patients have not been well studied.

A Systematic Review of Animal Models of NAFLD Finds High‐Fat, High‐Fructose Diets Most Closely Resemble Human NAFLD

Yu Ri Im, Harriet Hunter, Dana Gracia Hahn, Amedine Duret, Qinrong Cheah, Jiawen Dong, Madison Fairey, Clarissa Hjalmarsson, Alice Li, Hong Kai Lim, Lorcán McKeown, Claudia‐Gabriela Mitrofan, Raunak Rao, Mrudula Utukuri, Ian A. Rowe, Jake P. Mann – 10 May 2021

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