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Oral Vancomycin or Ursodeoxycholic Acid for Pediatric Primary Sclerosing Cholangitis? The Uncontroversial Need for Randomized Controlled Trials

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David N. Assis, Cynthia Levy – 4 January 2021

Loss of Coordinated Neutrophil Responses to the Human Fungal Pathogen, Candida albicans, in Patients With Cirrhosis

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Sally A.I. Knooihuizen, Natalie J. Alexander, Alex Hopke, Nicolas Barros, Adam Viens, Allison Scherer, Natalie J. Atallah, Zeina Dagher, Daniel Irimia, Raymond T. Chung, Michael K. Mansour – 4 January 2021 – Neutrophils are the most abundant white blood cell in the body and are key participants in the defense against fungal infections. Fungal infections occur often in patients with cirrhosis and are associated with increased 30‐day and 90‐day mortality.

Effects of Resmetirom on Noninvasive Endpoints in a 36‐Week Phase 2 Active Treatment Extension Study in Patients With NASH

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Stephen A. Harrison, Mustafa Bashir, Sam E. Moussa, Kevin McCarty, Juan Pablo Frias, Rebecca Taub, Naim Alkhouri – 3 January 2021 – Resmetirom (MGL‐3196), a selective thyroid hormone receptor‐β agonist, was evaluated in a 36‐week paired liver biopsy study (NCT02912260) in adults with biopsy‐confirmed nonalcoholic steatohepatitis (NASH). The primary endpoint was relative liver fat reduction as assessed by MRI–proton density fat fraction (MRI‐PDFF), and secondary endpoints included histopathology.