Liver Stiffness by Transient Elastography to Detect Porto‐Sinusoidal Vascular Liver Disease With Portal Hypertension

Laure Elkrief, Marie Lazareth, Sylvie Chevret, Valérie Paradis, Marta Magaz, Lorraine Blaise, Laura Rubbia‐Brandt, Lucile Moga, François Durand, Audrey Payancé, Aurélie Plessier, Cendrine Chaffaut, Dominique Valla, Marion Malphettes, Alba Diaz, Jean‐Charles Nault, Pierre Nahon, Etienne Audureau, Vlad Ratziu, Laurent Castera, Juan‐Carlos Garcia Pagan, Nathalie Ganne‐Carrie, Pierre‐Emmanuel Rautou, the ANRS CO12 CirVir Group – 21 December 2020

A Real‐World Observational Cohort of Patients with Hepatocellular Carcinoma: Design and Rationale for TARGET‐HCC

Roniel Cabrera, Amit G. Singal, Massimo Colombo, R. Kate Kelley, Hannah Lee, Andrea R. Mospan, Tim Meyer, Pippa Newell, Neehar D. Parikh, Bruno Sangro, K. Rajender Reddy, Stephanie Watkins, Richard C. Zink, Adrian M. Di Bisceglie – 21 December 2020 – This study describes the design of the TARGET‐hepatocellular carcinoma (HCC) cohort and descriptive characteristics of the patient population at diagnosis among those who were enrolled in the cohort across academic and community clinical centers.

Establishment of a Cell Culture Model Permissive for Infection by Hepatitis B and C Viruses

Teruhime Otoguro, Tomohisa Tanaka, Hirotake Kasai, Nobuhiro Kobayashi, Atsuya Yamashita, Takasuke Fukuhara, Akihide Ryo, Moto Fukai, Akinobu Taketomi, Yoshiharu Matsuura, Kohji Moriishi – 19 December 2020 – Compared with each monoinfection, coinfection with hepatitis B virus (HBV) and hepatitis C virus (HCV) is well known to increase the risks of developing liver cirrhosis and hepatocellular carcinoma. However, the mechanism by which HBV/HCV coinfection is established in hepatocytes is not well understood.

High‐Fat Diet Modulates Hepatic Amyloid β and Cerebrosterol Metabolism in the Triple Transgenic Mouse Model of Alzheimer’s Disease

Cristina R. Bosoi, Milène Vandal, Marine Tournissac, Manon Leclerc, Hortense Fanet, Patricia L. Mitchell, Mélanie Verreault, Jocelyn Trottier, Jessica Virgili, Cynthia Tremblay, H. Robert Lippman, Jasmohan S. Bajaj, Olivier Barbier, André Marette, Frédéric Calon – 18 December 2020 – Obesity and diabetes are strongly associated not only with fatty liver but also cognitive dysfunction. Moreover, their presence, particularly in midlife, is recognized as a risk factor for Alzheimer’s disease (AD).

Liver Disease and Coronavirus Disease 2019: From Pathogenesis to Clinical Care

Antonio Saviano, Florian Wrensch, Marc G. Ghany, Thomas F. Baumert – 17 December 2020 – Infection with the severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), a novel coronavirus that emerged in late 2019, is posing an unprecedented challenge to global health. Coronavirus disease 2019 (COVID‐19), the clinical disease caused by SARS‐CoV‐2, has a variable presentation ranging from asymptomatic infection to life‐threatening acute respiratory distress syndrome and multiorgan failure.

Targeting the De Novo Purine Synthesis Pathway Through Adenylosuccinate Lyase Depletion Impairs Liver Cancer Growth by Perturbing Mitochondrial Function

Tingting Jiang, Francisco J. Sánchez‐Rivera, Yadira M. Soto‐Feliciano, Qiyuan Yang, Chun‐Qing Song, Arjun Bhuatkar, Cole M Haynes, Michael T. Hemann, Wen Xue – 17 December 2020

LiverLearning®: 2020 Webinar: New E/M Requirements are Coming January 1: Will You Be Ready?

On January 1, 2021, the Centers for Medicare & Medicaid Services will be implementing significant changes to the outpatient evaluation and management (E/M) codes (CPT® codes 99202-99215) for new and established patients. The agency revised both the documentation requirements and values. Practices, physicians, and staff must understand these modifications to ensure a successful transition next year. To help prepare, AASLD is holding a webinar to explain these changes, including how to correctly bill and document the revised code set, on December 15 at 3pm ET.

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