Albumin in Advanced Liver Diseases: The Good and Bad of a Drug!

Rakesh Kumar Jagdish, Jaswinder Singh Maras, Shiv Kumar Sarin – 26 March 2021 – Human serum albumin is the most abundant plasma protein, and it regulates diverse body functions. In patients with advanced and decompensated cirrhosis, serum albumin levels are low because of a reduction in the hepatocyte mass due to disease per se and multiple therapeutic interventions.

A Mouse Model of Cholangiocarcinoma Uncovers a Role for Tensin‐4 in Tumor Progression

Mickaël Di‐Luoffo, Sophie Pirenne, Thoueiba Saandi, Axelle Loriot, Claude Gérard, Nicolas Dauguet, Fátima Manzano‐Núñez, Natália Alves Souza Carvalhais, Florence Lamoline, Sabine Cordi, Katarzyna Konobrocka, Vitaline De Greef, Mina Komuta, Georg Halder, Patrick Jacquemin, Frédéric P. Lemaigre – 25 March 2021

Elective Surgery but not Transjugular Intrahepatic Portosystemic Shunt Precipitates Acute‐On‐Chronic Liver Failure

Johannes Chang, Avend Bamarni, Nina Böhling, Xin Zhou, Leah‐Marie Klein, Jonathan Meinke, Georg Daniel Duerr, Philipp Lingohr, Sven Wehner, Maximilian J. Brol, Jürgen K. Rockstroh, Jörg C. Kalff, Steffen Manekeller, Carsten Meyer, Ulrich Spengler, Christian Jansen, Vicente Arroyo, Christian P. Strassburg, Jonel Trebicka, Michael Praktiknjo – 25 March 2021 – Acute‐on‐chronic liver failure (ACLF) is a syndrome associated with organ failure and high short‐term mortality.

Tumor Necrosis Factor α–Induced Protein 8–Like 2 Alleviates Nonalcoholic Fatty Liver Disease Through Suppressing Transforming Growth Factor Beta–Activated Kinase 1 Activation

Yupeng Liu, Jingjing Song, Juan Yang, Jilin Zheng, Ling Yang, Jun Gao, Song Tian, Zhen Liu, Xiangbin Meng, Jian‐Cheng Wang, Zhifei Dai, Yi‐Da Tang – 25 March 2021

Impact of Metabolic Activity in Hepatocellular Carcinoma: Association With Immune Status and Vascular Formation

Shinji Itoh, Tomoharu Yoshizumi, Yoshiyuki Kitamura, Kyohei Yugawa, Norifumi Iseda, Tomonari Shimagaki, Yoshihiro Nagao, Takeo Toshima, Noboru Harada, Kenichi Kohashi, Shingo Baba, Kousei Ishigami, Yoshinao Oda, Masaki Mori – 25 March 2021 – We evaluated the prognostic value of fluorine‐18 fluorodeoxyglucose (18F‐FDG) positron emission tomography/computed tomography (PET/CT) in hepatocellular carcinoma (HCC). Their association with programmed death ligand 1 (PD‐L1) expression and vascular formation was further investigated.

Hepcidin Signaling in Health and Disease: Ironing Out the Details

Kris V. Kowdley, Eric M. Gochanour, Vinay Sundaram, Raj A. Shah, Priya Handa – 25 March 2021 – Hepcidin, a peptide hormone produced by hepatocytes, is the central regulator of systemic iron homeostasis through its interaction with ferroportin, the major cellular iron export protein. Hepcidin binding to ferroportin results in reduced iron export from macrophages and intestinal absorptive cells, leading to decreased serum iron levels. Hepcidin expression is influenced by several factors that include serum and liver iron stores, erythropoiesis, hypoxia, inflammation, and infection.

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