Impact of Metabolic Activity in Hepatocellular Carcinoma: Association With Immune Status and Vascular Formation

Shinji Itoh, Tomoharu Yoshizumi, Yoshiyuki Kitamura, Kyohei Yugawa, Norifumi Iseda, Tomonari Shimagaki, Yoshihiro Nagao, Takeo Toshima, Noboru Harada, Kenichi Kohashi, Shingo Baba, Kousei Ishigami, Yoshinao Oda, Masaki Mori – 25 March 2021 – We evaluated the prognostic value of fluorine‐18 fluorodeoxyglucose (18F‐FDG) positron emission tomography/computed tomography (PET/CT) in hepatocellular carcinoma (HCC). Their association with programmed death ligand 1 (PD‐L1) expression and vascular formation was further investigated.

Hepcidin Signaling in Health and Disease: Ironing Out the Details

Kris V. Kowdley, Eric M. Gochanour, Vinay Sundaram, Raj A. Shah, Priya Handa – 25 March 2021 – Hepcidin, a peptide hormone produced by hepatocytes, is the central regulator of systemic iron homeostasis through its interaction with ferroportin, the major cellular iron export protein. Hepcidin binding to ferroportin results in reduced iron export from macrophages and intestinal absorptive cells, leading to decreased serum iron levels. Hepcidin expression is influenced by several factors that include serum and liver iron stores, erythropoiesis, hypoxia, inflammation, and infection.

Genetic Determinants of Outcome in Intrahepatic Cholangiocarcinoma

Thomas Boerner, Esther Drill, Linda M. Pak, Bastien Nguyen, Carlie S. Sigel, Alexandre Doussot, Paul Shin, Debra A. Goldman, Mithat Gonen, Peter J. Allen, Vinod P. Balachandran, Andrea Cercek, James Harding, David B. Solit, Nikolaus Schultz, Ritika Kundra, Henry Walch, Michael I. D’Angelica, Ronald P. DeMatteo, Jeffrey Drebin, Nancy E. Kemeny, T. Peter Kingham, Amber L. Simpson, Jaclyn F. Hechtman, Efsevia Vakiani, Maeve A. Lowery, J.N.M. Ijzermans, S. Buettner, B. Groot Koerkamp, M. Doukas, Rohit Chandwani, William R. Jarnagin – 24 March 2021

Proteomic Profiling of Hepatocellular Adenomas Paves the Way to Diagnostic and Prognostic Approaches

Cyril Dourthe, Céline Julien, Sylvaine Di Tommaso, Jean‐William Dupuy, Nathalie Dugot‐Senant, Alexandre Brochard, Brigitte Le Bail, Jean‐Frédéric Blanc, Laurence Chiche, Charles Balabaud, Paulette Bioulac‐Sage, Frédéric Saltel, Anne‐Aurélie Raymond – 22 March 2021

Experimental Models of Liquid Biopsy in Hepatocellular Carcinoma Reveal Clone‐Dependent Release of Circulating Tumor DNA

Ismail Labgaa, Johann Felden, Amanda J. Craig, Sebastiao N. Martins‐Filho, Carlos Villacorta‐Martin, Nicolas Demartines, Olivier Dormond, Delia D’Avola, Augusto Villanueva – 22 March 2021 – Liquid biopsy, the molecular analysis of tumor components released into the bloodstream, has emerged as a noninvasive and resourceful means to access genomic information from cancers. Most data derived from translational studies showcase its numerous potential clinical applications.

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