Hepatology Highlights

Alyson Kaplan, Russell Rosenblatt, Adam Buckholz, Sonal Kumar, Gopanandan Parthasarathy, Robert E. Schwartz, Petra Hirsova, Robert E. Schwartz, Joseph F. Pisa, Robert S. Brown, Nidhi Jalan‐Sakrikar, Robert E. Schwartz, Arun B. Jesudian, Nicholas W. Russo, Chaitanya Allamneni, Ravi S. Vora, Enis Kostallari, Robert E. Schwartz – 28 September 2020

Hepatology Highlights

Alyson Kaplan, Russell Rosenblatt, Adam Buckholz, Sonal Kumar, Gopanandan Parthasarathy, Robert E. Schwartz, Petra Hirsova, Robert E. Schwartz, Joseph F. Pisa, Robert S. Brown, Nidhi Jalan‐Sakrikar, Robert E. Schwartz, Arun B. Jesudian, Nicholas W. Russo, Chaitanya Allamneni, Ravi S. Vora, Enis Kostallari, Robert E. Schwartz – 28 September 2020

Reducing the Global Burden of Alcohol‐Associated Liver Disease: A Blueprint for Action

Sumeet K. Asrani, Jessica Mellinger, Juan P. Arab, Vijay H. Shah – 28 September 2020 – Alcohol‐associated liver disease (ALD) is a major driver of global liver related morbidity and mortality. There are 2.4 billion drinkers (950 million heavy drinkers) and the lifetime prevalence of any alcohol use disorder (AUD) is 5.1%‐8.6%. In 2017, global prevalence of alcohol‐associated compensated and decompensated cirrhosis was 23.6 million and 2.5 million, respectively.

Interferon Type I Regulates Inflammasome Activation and High Mobility Group Box 1 Translocation in Hepatocytes During Ehrlichia‐Induced Acute Liver Injury

Muhamuda Kader, Abdeljabar El Andaloussi, Jennie Vorhaour, Kenichi Tamama, Natalia Nieto, Melanie J. Scott, Nahed Ismail – 27 September 2020 – Inflammasomes are an important innate immune host defense against intracellular microbial infection. Activation of inflammasomes by microbial or host ligands results in cleavage of caspase‐1 (canonical pathway) or caspase‐11 (noncanonical pathway), release of interleukin (IL)‐1β, IL‐18, high mobility group box 1 (HMGB1), and inflammatory cell death known as pyroptosis.

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