Early Predictors of Short‐Term Prognosis in Acute and Acute Severe Autoimmune Hepatitis

Maaike Biewenga, Akin Inderson, Maarten E. Tushuizen, A. Stijn L.P. Crobach, Bart Hoek – 30 September 2020 – Presentation of autoimmune hepatitis (AIH) can differ from nonacute to acute autoimmune hepatitis (A‐AIH) with jaundice and acute severe autoimmune hepatitis (AS‐AIH) with jaundice and coagulopathy. The aim of the study was to evaluate the short‐term prognosis of different presentations of AIH and the influence of liver function improvement on short‐term prognosis.

Major Histocompatibility Complex Class I‐Related Chain A Alleles and Histology of Nonalcoholic Fatty Liver Disease

Azza Karrar, Bijal Rajput, Siddharth Hariharan, Dinan Abdelatif, Mohamad Houry, Ali Moosvi, Irfan Ali, Daisong Tan, Sohailla Noor, Donna Esmaeili, Sean Felix, Lakshmi Alaparthi, Munkhzul Otgonsuren, Brian Lam, Zachary D. Goodman, Zobair M. Younossi – 30 September 2020 – Major histocompatibility complex class I‐related chain A (MICA) is a highly polymorphic gene that modulates immune surveillance by binding to its receptor on natural killer cells, and its genetic polymorphisms have been associated with chronic immune‐mediated diseases.

The Impact of COVID‐19 on Organ Donation, Procurement, and Liver Transplantation in the United States

Jonathan Merola, Michael L. Schilsky, David C. Mulligan – 29 September 2020 – The coronavirus disease 2019 pandemic has had an impact on all facets of our health care system, including life‐saving procedures like organ transplantation. Concerns for potential exposure to the causative severe acute respiratory syndrome coronavirus type 2 have profoundly altered the process of organ donation and recovery that is vital to the execution of organ transplantation.

The Impact of COVID‐19 on Organ Donation, Procurement, and Liver Transplantation in the United States

Jonathan Merola, Michael L. Schilsky, David C. Mulligan – 29 September 2020 – The coronavirus disease 2019 pandemic has had an impact on all facets of our health care system, including life‐saving procedures like organ transplantation. Concerns for potential exposure to the causative severe acute respiratory syndrome coronavirus type 2 have profoundly altered the process of organ donation and recovery that is vital to the execution of organ transplantation.

Osteopontin Takes Center Stage in Chronic Liver Disease

Zhuolun Song, Wei Chen, Dipti Athavale, Xiaodong Ge, Romain Desert, Sukanta Das, Hui Han, Natalia Nieto – 28 September 2020 – Osteopontin (OPN) was first identified in 1986. The prefix osteo‐ means bone; however, OPN is expressed in other tissues, including liver. The suffix ‐pontin means bridge and denotes the role of OPN as a link protein within the extracellular matrix. While OPN has well‐established physiological roles, multiple “omics” analyses suggest that it is also involved in chronic liver disease.

Subscribe to