Utility of Mac‐2 Binding Protein Glycosylation Isomer to Evaluate Graft Status After Liver Transplantation

Yusuke Kimura, Kojiro Taura, Nguyen Hai Nam, Yusuke Uemoto, Kenji Yoshino, Yoshinobu Ikeno, Yukihiro Okuda, Takahiro Nishio, Gen Yamamoto, Kazutaka Tanabe, Yukinori Koyama, Takayuki Anazawa, Ken Fukumitsu, Takashi Ito, Shintaro Yagi, Naoko Kamo, Satoru Seo, Keiko Iwaisako, Koichiro Hata, Takumi Imai, Shinji Uemoto – 11 August 2020 – Mac‐2 binding protein glycosylation isomer (M2BPGi) is a novel liver fibrosis biomarker, but there are few studies on M2BPGi in liver transplantation (LT) recipients. This study aimed to evaluate the utility of M2BPGi measurement in LT recipients.

Sequential Protocol Biopsies Post–Liver Transplant From Donors With Moderate Macrosteatosis: What Happens to the Fat?

Kristopher P. Croome, David Livingston, Sarah Croome, Andrew P. Keaveny, C. Burcin Taner, Raouf Nakhleh – 11 August 2020 – The number of steatotic deceased donor livers encountered has continued to rise as a result of the obesity epidemic. Little is known about the histological characteristics of moderately macrosteatotic livers over time in the recipient following liver transplantation (LT). All recipients undergoing LT at Mayo Clinic Florida with donor livers with moderate macrosteatosis (30%‐60%) from 2000‐2017 were identified (n = 96).

Analysis of Hepatitis B Virus Haplotype Diversity Detects Striking Sequence Conservation Across Genotypes and Chronic Disease Phase

Josef Wagner, Lilly Yuen, Margaret Littlejohn, Vitina Sozzi, Kathy Jackson, Vithika Suri, Susanna Tan, Becket Feierbach, Anuj Gaggar, Patrick Marcellin, Maria Buti Ferret, Harry L.A. Janssen, Ed Gane, Henry L.Y. Chan, Danni Colledge, Gillian Rosenberg, Julianne Bayliss, Benjamin P Howden, Stephen A. Locarnini, Darren Wong, Alexander T. Thompson, Peter A. Revill – 11 August 2020

Coronary Computed Tomography Angiography Demonstrates a High Burden of Coronary Artery Disease Despite Low‐Risk Nuclear Studies in Pre–Liver Transplant Evaluation

Adrián I. Löffler, Jorge A. Gonzalez, Shriram K. Sundararaman, Roshin C. Mathew, Patrick T. Norton, Klaus D. Hagspiel, Christopher M. Kramer, Michael Ragosta, Campbell Rogers, Neeral L. Shah, Michael Salerno – 9 August 2020 – We investigated the presence and severity of coronary artery disease (CAD) in orthotopic liver transplantation (OLT) candidates using coronary artery calcium score (CACS) and coronary computed tomography angiography (CCTA) as compared with the prevalence of normal and abnormal single‐photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI).

Developmental Programming of NAFLD by Parental Obesity

Michael D. Thompson – 9 August 2020 – The surge of obesity across generations has become an increasingly relevant issue, with consequences for associated comorbidities in offspring. Data from longitudinal birth cohort studies support an association between maternal obesity and offspring nonalcoholic fatty liver disease (NAFLD), suggesting that perinatal obesity or obesogenic diet exposure reprograms offspring liver and increases NAFLD susceptibility.

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