Deficiency of miR‐208a Exacerbates CCl4‐Induced Acute Liver Injury in Mice by Activating Cell Death Pathways

Shashi Bala, Charles D. Calenda, Donna Catalano, Mrigya Babuta, Karen Kodys, Imad A. Nasser, Barbara Vidal, Gyongyi Szabo – 19 August 2020 – Acute liver injury (ALI) is associated with multiple cellular events such as necrosis, apoptosis, oxidative stress and inflammation, which can lead to liver failure. In this study, we demonstrate a new role of microRNA (miR)‐208a in ALI. ALI was induced in wild‐type (WT) and miR‐208a knockout (KO) mice by CCl4 administration. Increased alanine aminotransferase and decreased hepatic miR‐208a levels were found in WT mice after acute CCl4 treatment.

Development of Ectopic Livers by Hepatocyte Transplantation Into Swine Lymph Nodes

Paulo Fontes, Junji Komori, Roberto Lopez, Wallis Marsh, Eric Lagasse – 18 August 2020 – Orthotopic liver transplantation continues to be the only effective therapy for patients with end‐stage liver disease. Unfortunately, many of these patients are not considered transplant candidates, lacking effective therapeutic options that would address both the irreversible progression of their hepatic failure and the control of their portal hypertension. In this prospective study, a swine model was exploited to induce subacute liver failure.

Planned Initiation of Venoarterial Extracorporeal Membrane Oxygenation Prior to Liver Transplantation in a Patient With Severe Portopulmonary Hypertension

Andrew S. Barbas, Jacob N. Schroder, Deeplaxmi P. Borle, Arturo Suarez, Nader Abraham, Michael W. Manning, Timothy E. Miller, Carl L. Berg, Terry A. Fortin, Debra L. Sudan, Aparna S. Rege – 16 August 2020

Activated Protein Phosphatase 2A Disrupts Nutrient Sensing Balance Between Mechanistic Target of Rapamycin Complex 1 and Adenosine Monophosphate–Activated Protein Kinase, Causing Sarcopenia in Alcohol‐Associated Liver Disease

Gangarao Davuluri, Nicole Welch, Jinendiran Sekar, Mahesha Gangadhariah, Khaled Alsabbagh Alchirazi, Maradumane L. Mohan, Avinash Kumar, Sashi Kant, Samjhana Thapaliya, McKenzie Stine, Megan R. McMullen, Rebecca L. McCullough, George R. Stark, Laura E. Nagy, Sathyamangla V. Naga Prasad, Srinivasan Dasarathy – 16 August 2020

Yes‐Associated Protein Is Crucial for Constitutive Androstane Receptor‐Driven Hepatocyte Proliferation But Not for Induction of Drug Metabolism Genes in Mice

Bharat Bhushan, Laura Molina, Kelly Koral, John W. Stoops, Wendy M. Mars, Swati Banerjee, Anne Orr, Shirish Paranjpe, Satdarshan P. Monga, Joseph Locker, George K. Michalopoulos – 13 August 2020

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