Clinical Research in Hepatology in the COVID‐19 Pandemic and Post‐Pandemic Era: Challenges and the Need for Innovation

Elizabeth C. Verna, Marina Serper, Jaime Chu, Kathleen Corey, Oren K. Fix, Karen Hoyt, Kimberly A. Page, Rohit Loomba, Ming Li, Gregory T. Everson, Michael W. Fried, Guadalupe Garcia‐Tsao, Norah Terrault, Anna S. Lok, Raymond T. Chung, K. Rajender Reddy – 2 August 2020 – The severe acute respiratory syndrome coronavirus 2 pandemic has drastically altered all facets of clinical care and research.

Clinical Research in Hepatology in the COVID‐19 Pandemic and Post‐Pandemic Era: Challenges and the Need for Innovation

Elizabeth C. Verna, Marina Serper, Jaime Chu, Kathleen Corey, Oren K. Fix, Karen Hoyt, Kimberly A. Page, Rohit Loomba, Ming Li, Gregory T. Everson, Michael W. Fried, Guadalupe Garcia‐Tsao, Norah Terrault, Anna S. Lok, Raymond T. Chung, K. Rajender Reddy – 2 August 2020 – The severe acute respiratory syndrome coronavirus 2 pandemic has drastically altered all facets of clinical care and research.

LPCN 1144 Resolves NAFLD in Hypogonadal Males

Somaya Albhaisi, Kilyoung Kim, Jonathan Baker, Nachiappan Chidambaram, Mahesh V. Patel, Michael Charlton, Arun J. Sanyal – 2 August 2020 – Hypogonadism affects hepatic lipid metabolism and is expected to promote nonalcoholic fatty liver disease (NAFLD). The aims of this study were to determine (1) the prevalence of NAFLD in hypogonadal males and (2) the impact of correction of hypogonadism by LPCN 1144 (Lipocine, Inc., Salt Lake City, UT), an oral testosterone prodrug, on NAFLD in this population.

Health Care Resource Use and Cost Burden of Chronic Kidney Disease in Patients With Chronic Liver Disease: A Real‐World Claims Analysis

Vinod K. Rustgi, You Li, Tina John, Carolyn Catalano, Mohamed I. Elsaid – 2 August 2020 – Chronic Liver Disease (CLD) is associated with an increased risk of chronic kidney disease (CKD). However, the health care burden of CKD in the CLD spectrum is unknown. We aimed to evaluate the health care use and cost burdens associated with CKD in patients with CLD in the United States by using real‐world claims data. We analyzed data from the Truven Health MarketScan Commercial Claims database from 2010 to 2015.

Functional Role of the Secretin/Secretin Receptor Signaling During Cholestatic Liver Injury

Nan Wu, Leonardo Baiocchi, Tianhao Zhou, Lindsey Kennedy, Ludovica Ceci, Fanyin Meng, Keisaku Sato, Chaodong Wu, Burcin Ekser, Konstantina Kyritsi, Debjyoti Kundu, Lixian Chen, Vik Meadows, Antonio Franchitto, Domenico Alvaro, Paolo Onori, Eugenio Gaudio, Ilaria Lenci, Heather Francis, Shannon Glaser, Gianfranco Alpini – 1 August 2020

Functional Role of the Secretin/Secretin Receptor Signaling During Cholestatic Liver Injury

Nan Wu, Leonardo Baiocchi, Tianhao Zhou, Lindsey Kennedy, Ludovica Ceci, Fanyin Meng, Keisaku Sato, Chaodong Wu, Burcin Ekser, Konstantina Kyritsi, Debjyoti Kundu, Lixian Chen, Vik Meadows, Antonio Franchitto, Domenico Alvaro, Paolo Onori, Eugenio Gaudio, Ilaria Lenci, Heather Francis, Shannon Glaser, Gianfranco Alpini – 1 August 2020

The Power of Single‐Cell Analysis for the Study of Liver Pathobiology

Angela L. Chu, Joel D. Schilling, Kevin R. King, Ariel E. Feldstein – 1 August 2020 – Single cell transcriptomics has emerged as a powerful lens through which to study the molecular diversity of complex tissues such as the liver, during health and disease, both in animal models and in humans. The earliest gene expression methods measured bulk tissue RNA, but the results were often confusing because they derived from the combined transcriptomes of many different cell types in unknown proportions.

Prenatal Exposure to Perfluoroalkyl Substances Associated With Increased Susceptibility to Liver Injury in Children

Nikos Stratakis, David V. Conti, Ran Jin, Katerina Margetaki, Damaskini Valvi, Alexandros P. Siskos, Léa Maitre, Erika Garcia, Nerea Varo, Yinqi Zhao, Theano Roumeliotaki, Marina Vafeiadi, Jose Urquiza, Silvia Fernández‐Barrés, Barbara Heude, Xavier Basagana, Maribel Casas, Serena Fossati, Regina Gražulevičienė, Sandra Andrušaitytė, Karan Uppal, Rosemary R.C. McEachan, Eleni Papadopoulou, Oliver Robinson, Line Småstuen Haug, John Wright, Miriam B. Vos, Hector C. Keun, Martine Vrijheid, Kiros T. Berhane, Rob McConnell, Lida Chatzi – 1 August 2020

Prenatal Exposure to Perfluoroalkyl Substances Associated With Increased Susceptibility to Liver Injury in Children

Nikos Stratakis, David V. Conti, Ran Jin, Katerina Margetaki, Damaskini Valvi, Alexandros P. Siskos, Léa Maitre, Erika Garcia, Nerea Varo, Yinqi Zhao, Theano Roumeliotaki, Marina Vafeiadi, Jose Urquiza, Silvia Fernández‐Barrés, Barbara Heude, Xavier Basagana, Maribel Casas, Serena Fossati, Regina Gražulevičienė, Sandra Andrušaitytė, Karan Uppal, Rosemary R.C. McEachan, Eleni Papadopoulou, Oliver Robinson, Line Småstuen Haug, John Wright, Miriam B. Vos, Hector C. Keun, Martine Vrijheid, Kiros T. Berhane, Rob McConnell, Lida Chatzi – 1 August 2020

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