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Eduardo A. Rodriguez, Jorge Rakela, Hugo E. Vargas – 4 August 2020
Functionally Diverse Inflammatory Responses in Peripheral and Liver Monocytes in Alcohol‐Associated Hepatitis
Adam Kim, Annette Bellar, Megan R. McMullen, Xiaoxia Li, Laura E. Nagy – 4 August 2020 – Alcohol‐associated hepatitis (AH) is an acute inflammatory disease in which gut‐microbial byproducts enter circulation and peripheral immune cells infiltrate the liver, leading to nonresolving inflammation and injury. Single‐cell RNA sequencing of peripheral blood mononuclear cells isolated from patients with AH and healthy controls paired with lipopolysaccharide (LPS) challenge revealed how diverse monocyte responses are divided among individual cells and change in disease.
Bidirectional Role of NLRP3 During Acute and Chronic Cholestatic Liver Injury
Mick Frissen, Lijun Liao, Kai Markus Schneider, Sonja Djudjaj, Johannes Haybaeck, Alexander Wree, Ulrike Rolle‐Kampczyk, Martin Bergen, Eicke Latz, Peter Boor, Christian Trautwein – 4 August 2020
Hepatocellular Carcinoma–Circulating Tumor Cells Expressing PD‐L1 Are Prognostic and Potentially Associated With Response to Checkpoint Inhibitors
Paul Winograd, Shuang Hou, Colin M. Court, Yi‐Te Lee, Pin‐Jung Chen, Yazhen Zhu, Saeed Sadeghi, Richard S. Finn, Pai‐Chi Teng, Jasmin J. Wang, Zhicheng Zhang, Hongtao Liu, Ronald W. Busuttil, James S Tomlinson, Hsian‐Rong Tseng, Vatche G. Agopian – 4 August 2020 – Hepatocellular carcinoma (HCC) is a leading cause of mortality. Checkpoint inhibitors of programmed cell death protein‐1 (PD‐1) and programmed death‐ligand 1 (PD‐L1) have shown great efficacy, but lack biomarkers that predict response.
A Randomized Clinical Trial of Fecal Microbiota Transplant for Alcohol Use Disorder
Jasmohan S. Bajaj, Edith A. Gavis, Andrew Fagan, James B. Wade, Leroy R. Thacker, Michael Fuchs, Samarth Patel, Brian Davis, Jill Meador, Puneet Puri, Masoumeh Sikaroodi, Patrick M. Gillevet – 4 August 2020
Donor‐Transmitted Cancers in Transplanted Livers: Analysis of Clinical Outcomes
Albino Eccher, Ilaria Girolami, Stefano Marletta, Matteo Brunelli, Amedeo Carraro, Umberto Montin, Ugo Boggi, Claudia Mescoli, Luca Novelli, Deborah Malvi, Letizia Lombardini, Massimo Cardillo, Desley Neil, Antonietta D’Errico – 3 August 2020 – The risk of transmission of malignancy from donor to recipient is low. However, this occurrence has dramatic consequences. Many reports of donor‐derived cancers in liver transplant recipients have been published, but they have not been systematically summarized into a lucid and unified analysis.
IgG 4 Autoimmune Hepatitis Presenting as Idiopathic Hypereosinophilia Syndrome
Darren Kastin, Matthew Siegel, Richard Anderson, Andrew Aronsohn – 3 August 2020
A Fibrosis‐Independent Hepatic Transcriptomic Signature Identifies Drivers of Disease Progression in Primary Sclerosing Cholangitis
Yevgeniy Gindin, Chuhan Chung, Zhaoshi Jiang, Jing Zhu Zhou, Jun Xu, Andrew N. Billin, Robert P. Myers, Zachary Goodman, Abdolamir Landi, Michael Houghton, Richard M. Green, Cynthia Levy, Kris V. Kowdley, Christopher L. Bowlus, Andrew J. Muir, Michael Trauner – 3 August 2020
Clinical Research in Hepatology in the COVID‐19 Pandemic and Post‐Pandemic Era: Challenges and the Need for Innovation
Elizabeth C. Verna, Marina Serper, Jaime Chu, Kathleen Corey, Oren K. Fix, Karen Hoyt, Kimberly A. Page, Rohit Loomba, Ming Li, Gregory T. Everson, Michael W. Fried, Guadalupe Garcia‐Tsao, Norah Terrault, Anna S. Lok, Raymond T. Chung, K. Rajender Reddy – 2 August 2020 – The severe acute respiratory syndrome coronavirus 2 pandemic has drastically altered all facets of clinical care and research.
Clinical Research in Hepatology in the COVID‐19 Pandemic and Post‐Pandemic Era: Challenges and the Need for Innovation
Elizabeth C. Verna, Marina Serper, Jaime Chu, Kathleen Corey, Oren K. Fix, Karen Hoyt, Kimberly A. Page, Rohit Loomba, Ming Li, Gregory T. Everson, Michael W. Fried, Guadalupe Garcia‐Tsao, Norah Terrault, Anna S. Lok, Raymond T. Chung, K. Rajender Reddy – 2 August 2020 – The severe acute respiratory syndrome coronavirus 2 pandemic has drastically altered all facets of clinical care and research.