Improving the Efficacy of Liver Cancer Immunotherapy: The Power of Combined Preclinical and Clinical Studies

Gen‐Sheng Feng, Kaisa L. Hanley, Yan Liang, Xiaoxue Lin – 26 July 2020 – Hepatocellular carcinoma (HCC) is a most deadly malignant disease worldwide, with no effective mechanism‐based therapy available. Therefore, following the “miracle” outcomes seen in a few patients at the advanced stages of melanoma or lung cancer, the immune checkpoint inhibitors (ICIs) immediately entered clinical trials for advanced HCC patients without pre‐clinical studies.

Liver Injury as a Surrogate for Inflammation and Predictor of Outcomes in COVID‐19

Kajali Mishra, Sandra Naffouj, Sarah Gorgis, Hanan Ibrahim, Sonika Gill, Raef Fadel, Abigail Chatfield, Amy Tang, Reena Salgia – 26 July 2020 – Respiratory failure is the most common cause of death in patients with corona virus disease 2019 (COVID‐19). There have been many investigations to determine predictors of bad outcomes in patients with this illness. Liver enzyme elevation has been described in hospitalized patients with severe COVID‐19; however, little is known about the significance of liver injury regarding outcomes.

Liver Injury as a Surrogate for Inflammation and Predictor of Outcomes in COVID‐19

Kajali Mishra, Sandra Naffouj, Sarah Gorgis, Hanan Ibrahim, Sonika Gill, Raef Fadel, Abigail Chatfield, Amy Tang, Reena Salgia – 26 July 2020 – Respiratory failure is the most common cause of death in patients with corona virus disease 2019 (COVID‐19). There have been many investigations to determine predictors of bad outcomes in patients with this illness. Liver enzyme elevation has been described in hospitalized patients with severe COVID‐19; however, little is known about the significance of liver injury regarding outcomes.

Risk Stratification Based on Chronic Liver Failure Consortium Acute Decompensation Score in Patients With Child‐Pugh B Cirrhosis and Acute Variceal Bleeding

Yong Lv, Zhengyu Wang, Kai Li, Qiuhe Wang, Wei Bai, Xulong Yuan, Tianlei Yu, Jing Niu, Zhiping Yang, Xuan Zhu, Jianbo Zhao, Hui Xue, Zaibo Jiang, Yuzheng Zhuge, Chunqing Zhang, Junhui Sun, Pengxu Ding, Weixin Ren, Yingchun Li, Kewei Zhang, Wenguang Zhang, Wengang Guo, Bohan Luo, Xiaomei Li, Jie Yuan, Na Han, Ying Zhu, Chuangye He, Zhanxin Yin, Daiming Fan, Guohong Han – 24 July 2020

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