Somaya Albhaisi, Kilyoung Kim, Jonathan Baker, Nachiappan Chidambaram, Mahesh V. Patel, Michael Charlton, Arun J. Sanyal – 2 August 2020 – Hypogonadism affects hepatic lipid metabolism and is expected to promote nonalcoholic fatty liver disease (NAFLD). The aims of this study were to determine (1) the prevalence of NAFLD in hypogonadal males and (2) the impact of correction of hypogonadism by LPCN 1144 (Lipocine, Inc., Salt Lake City, UT), an oral testosterone prodrug, on NAFLD in this population.

Vinodhini Arjunan, Aida Hansen, Anja Deutzmann, Daniel Y. Sze, Renumathy Dhanasekaran – 2 August 2020

Nikos Stratakis, David V. Conti, Ran Jin, Katerina Margetaki, Damaskini Valvi, Alexandros P. Siskos, Léa Maitre, Erika Garcia, Nerea Varo, Yinqi Zhao, Theano Roumeliotaki, Marina Vafeiadi, Jose Urquiza, Silvia Fernández‐Barrés, Barbara Heude, Xavier Basagana, Maribel Casas, Serena Fossati, Regina Gražulevičienė, Sandra Andrušaitytė, Karan Uppal, Rosemary R.C. McEachan, Eleni Papadopoulou, Oliver Robinson, Line Småstuen Haug, John Wright, Miriam B. Vos, Hector C. Keun, Martine Vrijheid, Kiros T. Berhane, Rob McConnell, Lida Chatzi – 1 August 2020

Mohammad Golriz, Ali Ramouz, Arianeb Mehrabi – 1 August 2020

Angela L. Chu, Joel D. Schilling, Kevin R. King, Ariel E. Feldstein – 1 August 2020 – Single cell transcriptomics has emerged as a powerful lens through which to study the molecular diversity of complex tissues such as the liver, during health and disease, both in animal models and in humans. The earliest gene expression methods measured bulk tissue RNA, but the results were often confusing because they derived from the combined transcriptomes of many different cell types in unknown proportions.

Xuewei Bai, Hongyu Zhang, Yamei Zhou, Katsuya Nagaoka, Jialin Meng, Chengcheng Ji, Dan Liu, Xianghui Dong, Kevin Cao, Joud Mulla, Zhixiang Cheng, William Mueller, Amalia Bay, Grace Hildebrand, Shaolei Lu, Joselynn Wallace, Jack R. Wands, Bei Sun, Chiung‐Kuei Huang – 1 August 2020

Angela L. Chu, Joel D. Schilling, Kevin R. King, Ariel E. Feldstein – 1 August 2020 – Single cell transcriptomics has emerged as a powerful lens through which to study the molecular diversity of complex tissues such as the liver, during health and disease, both in animal models and in humans. The earliest gene expression methods measured bulk tissue RNA, but the results were often confusing because they derived from the combined transcriptomes of many different cell types in unknown proportions.

Hannah P. Kim, Sarah R. Lieber, Michael E. Rogers, Andrew M. Moon, Marci Loiselle, Jennifer Walker, David N. Assis, Ricky Safer, Rachel Gomel, Donna M. Evon – 1 August 2020 – Primary biliary cholangitis (PBC) and primary sclerosing cholangitis (PSC) are associated with decreased health‐related quality of life and debilitating symptoms. These experiences can be defined as patient‐reported outcome (PRO) concepts and measured using PRO instruments. We identified all PRO concepts and instruments used in the PBC and PSC literature.

Henry Shiau, Danielle Guffey, Kathleen M. Loomes, Christa Seidman, Emily Ragozzino, Jean P. Molleston, Deborah Schady, Daniel H. Leung – 1 August 2020 – Alagille syndrome (ALGS) and progressive familial intrahepatic cholestasis (PFIC) are inherited cholestatic disorders with risk of developing end‐stage liver disease requiring liver transplantation (LT). We investigated aspartate aminotransferase‐to‐platelet ratio index (APRI), Fibrosis‐4 score (FIB‐4), and conjugated bilirubin as biomarkers to assess fibrosis severity and risk for LT among children with ALGS and PFIC.

Nan Wu, Leonardo Baiocchi, Tianhao Zhou, Lindsey Kennedy, Ludovica Ceci, Fanyin Meng, Keisaku Sato, Chaodong Wu, Burcin Ekser, Konstantina Kyritsi, Debjyoti Kundu, Lixian Chen, Vik Meadows, Antonio Franchitto, Domenico Alvaro, Paolo Onori, Eugenio Gaudio, Ilaria Lenci, Heather Francis, Shannon Glaser, Gianfranco Alpini – 1 August 2020