Fatty Acid Desaturase 1 Influences Hepatic Lipid Homeostasis by Modulating the PPARα‐FGF21 Axis

Shaminie Athinarayanan, Yang‐Yi Fan, Xiaokun Wang, Evelyn Callaway, Defeng Cai, Naga Chalasani, Robert S. Chapkin, Wanqing Liu – 25 December 2020 – The fatty acid desaturase 1 (FADS1), also known as delta‐5 desaturase (D5D), is one of the rate‐limiting enzymes involved in the desaturation and elongation cascade of polyunsaturated fatty acids (PUFAs) to generate long‐chain PUFAs (LC‐PUFAs). Reduced function of D5D and decreased hepatic FADS1 expression, as well as low levels of LC‐PUFAs, were associated with nonalcoholic fatty liver disease.

Overexpression of Mothers Against Decapentaplegic Homolog 7 Activates the Yes‐Associated Protein/NOTCH Cascade and Promotes Liver Carcinogenesis in Mice and Humans

Haichuan Wang, Xinhua Song, Haotian Liao, Pan Wang, Yi Zhang, Li Che, Jie Zhang, Yi Zhou, Antonio Cigliano, Cindy Ament, Daphne Superville, Silvia Ribback, Melissa Reeves, Giovanni M. Pes, Binyong Liang, Hong Wu, Matthias Evert, Diego F. Calvisi, Yong Zeng, Xin Chen – 24 December 2020

Hepatology Highlights

Adam Buckholz, Robert S. Brown, Hirsh Trivedi, Muzammil M. Khan, Hira Hanif, Daryl T.Y. Lau, Amneet Hans, Giorgio Roccaro, Joseph F. Pisa, Nidhi Jalan‐Sakrikar, Robert E. Schwartz, Nicholas W. Russo, Tejasav S. Sehrawat, Enis Kostallari, Adebowale O. Bamidele, Gopanandan Parthasarathy – 23 December 2020

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