Sequential Protocol Biopsies Post–Liver Transplant From Donors With Moderate Macrosteatosis: What Happens to the Fat?

Kristopher P. Croome, David Livingston, Sarah Croome, Andrew P. Keaveny, C. Burcin Taner, Raouf Nakhleh – 11 August 2020 – The number of steatotic deceased donor livers encountered has continued to rise as a result of the obesity epidemic. Little is known about the histological characteristics of moderately macrosteatotic livers over time in the recipient following liver transplantation (LT). All recipients undergoing LT at Mayo Clinic Florida with donor livers with moderate macrosteatosis (30%‐60%) from 2000‐2017 were identified (n = 96).

Utility of Mac‐2 Binding Protein Glycosylation Isomer to Evaluate Graft Status After Liver Transplantation

Yusuke Kimura, Kojiro Taura, Nguyen Hai Nam, Yusuke Uemoto, Kenji Yoshino, Yoshinobu Ikeno, Yukihiro Okuda, Takahiro Nishio, Gen Yamamoto, Kazutaka Tanabe, Yukinori Koyama, Takayuki Anazawa, Ken Fukumitsu, Takashi Ito, Shintaro Yagi, Naoko Kamo, Satoru Seo, Keiko Iwaisako, Koichiro Hata, Takumi Imai, Shinji Uemoto – 11 August 2020 – Mac‐2 binding protein glycosylation isomer (M2BPGi) is a novel liver fibrosis biomarker, but there are few studies on M2BPGi in liver transplantation (LT) recipients. This study aimed to evaluate the utility of M2BPGi measurement in LT recipients.

Hepatocellular Carcinoma Survival by Etiology: A SEER‐Medicare Database Analysis

Gagandeep Brar, Tim F. Greten, Barry I. Graubard, Timothy S. McNeel, Jessica L. Petrick, Katherine A. McGlynn, Sean F. Altekruse – 9 August 2020 – In the United States, hepatocellular carcinoma (HCC) survival varies with tumor characteristics, patient comorbidities, and treatment. The effect of HCC etiology on survival is less clearly defined. The relationship between HCC etiology and mortality was examined using Surveillance, Epidemiology, and End Results–Medicare data.

Developmental Programming of NAFLD by Parental Obesity

Michael D. Thompson – 9 August 2020 – The surge of obesity across generations has become an increasingly relevant issue, with consequences for associated comorbidities in offspring. Data from longitudinal birth cohort studies support an association between maternal obesity and offspring nonalcoholic fatty liver disease (NAFLD), suggesting that perinatal obesity or obesogenic diet exposure reprograms offspring liver and increases NAFLD susceptibility.

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