Flavin Adenine Dinucleotide Depletion Caused by electron transfer flavoprotein subunit alpha Haploinsufficiency Leads to Hepatic Steatosis and Injury in Zebrafish

Ki‐Hoon Park, Monika Gooz, Zhi‐Wei Ye, Jie Zhang, Gyda C. Beeson, Don C. Rockey, Seok‐Hyung Kim – 1 March 2021 – The electron transfer flavoprotein (ETF) complex, made up of the ETF alpha subunit (ETFA), ETF beta subunit (ETFB), and ETF dehydrogenase (ETFDH), regulates fatty acid β‐oxidation activity while scavenging leaked electrons through flavin adenine dinucleotide (FAD)/reduced form FAD (FADH2) redox reactions in mitochondria.

Post‐transplant Lymphoproliferative Disorders After Liver Transplantation: A Retrospective Cohort Study Including 1954 Transplants

Tetsuya Tajima, Koichiro Hata, Hironori Haga, Momoko Nishikori, Katsutsugu Umeda, Jiro Kusakabe, Hidetaka Miyauchi, Tatsuya Okamoto, Eri Ogawa, Mari Sonoda, Hidefumi Hiramatsu, Masakazu Fujimoto, Hideaki Okajima, Junko Takita, Akifumi Takaori‐Kondo, Shinji Uemoto – 1 March 2021 – Post‐transplant lymphoproliferative disorders (PTLDs) are life‐threatening neoplasms after organ transplantation. Because of their rarity and multiple grades of malignancy, the incidence, outcomes, and clinicopathological features affecting patient survival after liver transplantation (LT) remain unclear.

Distinct Immune Imprints of Post–Liver Transplantation Hepatitis C Persist Despite Viral Clearance

Amare Aregay, Bastian Engel, Kerstin Port, Florian W.R. Vondran, Birgit Bremer, Christian Niehaus, Tanvi Khera, Nicolas Richter, Elmar Jaeckel, Markus Cornberg, Richard Taubert, Heiner Wedemeyer – 27 February 2021 – Recurrence or de novo infection of hepatitis C virus (HCV) after liver transplantation (LT) has been associated with progressive graft hepatitis that can be improved by treatment with novel direct‐acting antivirals. Cases of rejection episodes have been described during and after HCV treatment.

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